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Sleep Disorders and Risk of Incident Depression: A Population Case–Control Study

  • Enda M. Byrne (a1), Allan Timmerman (a2) (a3), Naomi R. Wray (a1) (a4) and Esben Agerbo (a2) (a3) (a5)

Abstract

We sought to investigate the risk of incident major depressive disorder (MDD) attributable to a range of sleep disorders in the Danish population. Data were obtained by linking longitudinal Danish population-based registers. A total of 65,739 individuals who had first onset of depression between 1995 and 2013 were selected as cases. For each case, a set of 20 controls of the same sex, birth month and year and who had not had depression by the date that the case was diagnosed were selected at random form the population (N = 1,307,580 in total). We examined whether there was an increased rate of prior sleep disorders in MDD cases compared to controls using conditional logistic regression. An increased risk of incident depression in cases was found for all sleep disorders analyzed. Highest incidence rate ratios (IRRs) were found for circadian rhythm disorders (IRR = 7.06 [2.78–17.91]) and insomnia of inorganic origin (IRR = 6.76 [4.37–10.46]). The lowest estimated IRR was for narcolepsy (IRR = 2.00 [1.26–3.17]). Those diagnosed with a sleep disorder in the last 6 months were at highest risk of developing depression compared to those with at least 1 year since diagnosis (3.10 vs. 2.36). Our results suggest that having any sleep disorder is a risk factor for incident depression. Depression screening should be considered for patients with sleep disorders, and where possible, long-term follow-up for mental health problems is advisable.

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Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

Author for correspondence: Enda M. Byrne, Email: enda.byrne@uq.edu.au

Footnotes

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The work was conducted at the Center for Integrated Register-based Research at Aarhus University, Aarhus, Denmark

Footnotes

References

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American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author.
Baglioni, C., Battagliese, G., Feige, B., Spiegelhalder, K., Nissen, C., Voderholzer, U., … Riemann, D. (2011). Insomnia as a predictor of depression: A meta-analytic evaluation of longitudinal epidemiological studies. Journal of Affective Disorders, 135, 1019.
Beauchemin, K. M., & Hays, P. (1996). Dreaming away depression: The role of REM sleep and dreaming in affective disorders. Journal of Affective Disorders, 41, 125133.
Becker, P. M., & Sharon, D. (2014). Mood disorders in restless legs syndrome (Willis-Ekbom disease). Journal of Clinical Psychiatry, 75, e679e694.
Borgan, O., Goldstein, L., & Langholz, B. (1995). Methods for the analysis of sampled cohort data in the Cox proportional hazards model. Annals of Statistics, 23, 17491778.
Breslau, N., Roth, T., Rosenthal, L., & Andreski, P. (1996). Sleep disturbance and psychiatric disorders: A longitudinal epidemiological study of young adults. Biological Psychiatry, 39, 411418.
Christensen, H., Batterham, P. J., Gosling, J. A., Ritterband, L. M., Griffiths, K. M., Thorndike, F. P., … Mackinnon, A. J. (2016). Effectiveness of an online insomnia program (SHUTi) for prevention of depressive episodes (the GoodNight Study): A randomised controlled trial. Lancet Psychiatry, 3, 333341.
Ford, D. E., & Kamerow, D. B. (1989). Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention? JAMA, 262, 14791484.
Fortuyn, H. A., Lappenschaar, M. A., Furer, J. W., Hodiamont, P. P., Rijnders, C. A., Renier, W. O., … Overeem, S. (2010). Anxiety and mood disorders in narcolepsy: A case-control study. General Hospital Psychiatry, 32, 4956.
Germain, A., & Kupfer, D. J. (2008). Circadian rhythm disturbances in depression. Human Psychopharmacology, 23, 571585.
Harris, M., Glozier, N., Ratnavadivel, R., & Grunstein, R. R. (2009). Obstructive sleep apnea and depression. Sleep Medicine Reviews, 13, 437444.
Kales, J. D., Kales, A., Soldatos, C. R., Caldwell, A. B., Charney, D. S., & Martin, E. D. (1980). Night terrors. Clinical characteristics and personality patterns. Archives of General Psychiatry, 37, 14131417.
Krishnan, R. R., Volow, M. R., Miller, P. P., & Carwile, S. T. (1984). Narcolepsy: Preliminary retrospective study of psychiatric and psychosocial aspects. American Journal of Psychiatry, 141, 428431.
Laursen, T. M., Musliner, K. L., Benros, M. E., Vestergaard, M., & Munk-Olsen, T. (2016). Mortality and life expectancy in persons with severe unipolar depression. Journal of Affective Disorders, 193, 203207.
Llorente, M. D., Currier, M. B., Norman, S. E., & Mellman, T. A. (1992). Night terrors in adults: phenomenology and relationship to psychopathology. Journal of Clinical Psychiatry, 53, 392394.
Lynge, E., Sandegaard, J. L., & Rebolj, M. (2011). The Danish National Patient Register. Scandinavian Journal of Public Health, 39, 3033.
Mors, O., Perto, G. P., & Mortensen, P. B. (2011). The Danish Psychiatric Central Research Register. Scandinavian Journal of Public Health, 39, 5457.
Munk-Jorgensen, P., & Mortensen, P. B. (1997). The Danish Psychiatric Central Register. Danish Medical Bulletin, 44, 8284.
Ohayon, M. M. (2013). Narcolepsy is complicated by high medical and psychiatric comorbidities: A comparison with the general population. Sleep Medicine, 14, 488492.
Pedersen, C. B. (2011). The Danish Civil Registration System. Scandinavian Journal of Public Health, 39, 2225.
Pedersen, C. B., Gotzsche, H., Moller, J. O., & Mortensen, P. B. (2006). The Danish Civil Registration System. A cohort of eight million persons. Danish Medical Bulletin, 53, 441449.
Pedersen, C. B., Mors, O., Bertelsen, A., Waltoft, B. L., Agerbo, E., McGrath, J. J., … Eaton, W. W. (2014). A comprehensive nationwide study of the incidence rate and lifetime risk for treated mental disorders. JAMA Psychiatry, 71, 573581.
Peppard, P. E., Szklo-Coxe, M., Hla, K. M., & Young, T. (2006). Longitudinal association of sleep-related breathing disorder and depression. Archives of Internal Medicine, 166, 17091715.
Perlis, M. L., Smith, L. J., Lyness, J. M., Matteson, S. R., Pigeon, W. R., Jungquist, C. R., & Tu, X. (2006). Insomnia as a risk factor for onset of depression in the elderly. Behavioral Sleep Medicine, 4, 104113.
Petersson, F., Baadsgaard, M., & Thygesen, L. C. (2011). Danish registers on personal labour market affiliation. Scandinavian Journal of Public Health, 39, 9598.
Roy, A. (1976). Psychiatric aspects of narcolepsy. British Journal of Psychiatry, 128, 562565.
Saunamaki, T., & Jehkonen, M. (2007). Depression and anxiety in obstructive sleep apnea syndrome: A review. Acta Neurologica Scandinavica, 116, 277288.
Vandeputte, M., & de Weerd, A. (2003 ). Sleep disorders and depressive feelings: A global survey with the Beck depression scale. Sleep Medicine, 4, 343345.
Vourdas, A., Shneerson, J. M., Gregory, C. A., Smith, I. E., King, M. A., Morrish, E., & McKenna, P. J. (2002). Narcolepsy and psychopathology: Is there an association? Sleep Medicine, 3, 353360.

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