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The Relationship Between Neuroticism and Inflammatory Markers: A Twin Study

  • Arthur A. Sas (a1), Frühling V. Rijsdijk (a2), Johan Ormel (a3), Harold Snieder (a1) and Harriëtte Riese (a1) (a3)...

Abstract

Introduction: Neuroticism is an important marker of vulnerability for both mental and physical disorders. Its link with multiple etiological pathways has been studied before. Inflammatory markers have been demonstrated to predict similar mental and physical disorders as neuroticism. However, currently no study has focused on the shared genetic background of neuroticism and inflammatory markers. In the present study we will focus on the phenotypic and genetic relationship between neuroticism and three commonly used inflammatory markers: C-reactive protein (CRP), fibrinogen and Immunoglobulin-G (IgG). Material and Methods: The study was conducted in 125 Dutch female twin pairs. For each participant, four different neuroticism scores were available to calculate a neuroticism composite score that was used in the statistical analyses. Blood samples for inflammatory marker determination were taken after an overnight fast. Heritabilities, phenotypic and genetic correlations were estimated using bivariate structural equation modeling. Results: Heritabilities are fair for neuroticism (0.55), CRP (0.52) and fibrinogen (0.67) and moderate for IgG (0.43). No significant phenotypic or genetic correlations were found between neuroticism and the inflammatory markers. Interaction models yielded no moderation of the genetic and environmental pathways in the regulation of inflammatory markers by neuroticism. Conclusion: Substantial heritabilities were observed for all variables. No evidence was found for significant shared (or moderation of) genetic or environmental pathways underlying neuroticism and inflammatory status.

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Copyright

Corresponding author

address for correspondence: Harriëtte Riese, PhD, Department of Psychiatry (CC72), University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. E-mail: h.riese@umcg.nl

References

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Bladbjerg, E. M., de Maat, M. P., Christensen, K., Bathum, L., Jespersen, J., & Hjelmborg, J. (2006). Genetic influence on thrombotic risk markers in the elderly: A Danish twin study. Journal of Thrombosis and Haemostasis, 4, 599607.
Buske-Kirschbaum, A., Geiben, A., & Hellhammer, D. (2001). Psychobiological aspects of atopic dermatitis: An overview. Psychotherapy and Psychosomatics, 70, 616.
Campbell, D. D., Rijsdijk, F. V., & Sham, P. C. (2007). Computation of individual latent variable scores from data with multiple missingness patterns. Behavior Genetics, 37, 408422.
Costa, P. T., & McCrae, R. R. (1987). Neuroticism, somatic complaints and disease: Is the bark worse than the bite? Journal of Personality, 55, 299316.
Costa, P. T., & McCrae, R. R. (1992). Revised NEO Personality Inventory (NEOPI-R) and the Five Factor Inventory (NEO-FFI): Professional manual. Odessa, FL: Psychological Assessment Resources.
Cuijpers, P., Smit, F., Penninx, B. W., de Graaf, R., ten Have, M., & Beekman, A. T. (2010). Economic costs of neuroticism: A population-based study. Archives of General Psychiatry, 67, 10861093.
Daruna, J. H. (1996). Neuroticism predicts normal variability in the number of circulating leucocytes. Personality and Individual Differences, 20, 103108.
Heath, A. C., Jardine, R., Eaves, L. J. & Martin, N. G. (1989). The genetic structure of personality, II. Genetic item analysis of the EPQ. Personality and Individual Differences, 10, 615624.
Hoekstra, H. A., Ormel, J., & De Fruyt, F. (1996). NEO-PI-R NEO-FFI. Big Five Persoonlijkheidsvragenlijsten [NEO-PI-R NEO-FFI. Big Five Personality Inventory]. Lisse, the Netherlands: Swets Test Service.
Kendler, K. S., Gardner, C. O., & Prescott, C. A. (2002). Toward a comprehensive developmental model for major depression in women. American Journal of Psychiatry, 159, 11331145.
Lahey, B. B. (2009). Public health significance of neuroticism. American Psychologist, 64, 241256.
McManus, D. D., Beaulieu, L. M., Mick, E., Tanriverdi, K., Larson, M.G., Keaney, J. F. Jr, Benjamin, E. J., & Freedman, J. E. (2013). Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk. Arteriosclerosis Thrombosis, and Vascular Biology, 33, 26662673.
Millar, K., Lloyd, S. M., McLean, J. S., Batty, G. D., Burns, H., Cavanagh, J., . . . Tannahill, C. (2013). Personality, socio-economic status and inflammation: Cross-sectional, population-based study. PLoSOne, 8, e58256.
Neale, M. C., Boker, S. M., Xie, G., & Maes, H. H. (2003). Mx: Statistical mod-eling (6th ed.). Richmond, VA: Virginia Commonwealth University, Department of Psychiatry.
Neale, M. C., & Cardon, L. R. (1992). Methodology for genetic studies of twins and families. Dordrecht: Kluwer Academic Publishers.
Nichols, R., & Bilbro, W. (1966). Diagnosis of twin zygosity. Acta Genetica et Statistica Medica, 16, 265275.
Ormel, J., Bastiaansen, A., Riese, H., Bos, E. H., Servaas, M., Ellenbogen, M., . . . Aleman, A. (2013a). The biological and psychological basis of neuroticism: current status and future directions. Neuroscience and Biobehavioral Reviews, 37, 5972.
Ormel, J., Jeronimus, B. F., Kotov, R., Riese, H., Bos, E. H., Hankin, B., . . . Oldehinkel, A. J. (2013b). Neuroticism and common mental disorders: Meaning and utility of a complex relationship. Clinical Psychology Review, 33, 686–97.
Rahman, I., Bennet, A. M., Pedersen, N. L., de Faire, U., Svensson, P., & Magnusson, P. K. E. (2009). Genetic dominance influences blood biomarker levels in a sample of 12,000 Swedish Elderly Twins. Twin Research and Human Genetics, 12, 286294.
Rettew, D. C., Vink, J. M., Willemsen, G., Doyle, A., Hudziak, J. J., & Boomsma, D. I. (2006). The genetic architecture of neuroticism in 3301 Dutch adolescent twins as a function of age and sex: A study from the Dutch Twin Register. Twin Research and Human Genetics, 9, 2429.
Riese, H., Rijsdijk, F. V., Rosmalen, J. G., Snieder, H., & Ormel, J. (2009). Neuroticism and morning cortisol secretion: Both heritable, but no shared genetic influences. Journal of Personality, 77, 15611575.
Riese, H., Rijsdijk, F. V., Snieder, H., & Ormel, J. (2013). The Twin Interdisciplinary Neuroticism Study. Twin Research and Human Genetics, 16, 268270.
Riese, H., Rosmalen, J. G. M., Ormel, J., van Roon, A. M., Oldehinkel, A. J., & Rijsdijk, F. V. (2007). The genetic relationship between neuroticism and autonomic function in female twins. Psychological Medicine, 37, 257267.
Sanderman, R., Eysenck, S. B. G., & Arrindell, W. A. (1991). Cross-cultural comparisons of personality: The Netherlands and England. Psychological Reports, 69, 10911096.
Su, S., Miller, A. H., Snieder, H., Bremner, J. D., Ritchie, J., Maisano, C., . . . Vaccarino, V. (2009). Common genetic contributions to depressive symptoms and inflammatory markers in middle-aged men: The Twins Heart Study. Psychosomatic Medicine, 71, 152158.
Su, S., Snieder, H., Miller, A. H., Ritchie, J., Bremner, J. D., Goldberg, J., . . . Vaccarino, V. (2008). Genetic and environmental influences on systemic markers of inflammation in middle-aged male twins. Atherosclerosis, 200, 213220.
Suls, J., & Bunde, J. (2005). Anger, anxiety, and depression as risk factors for cardiovascular disease: The problems and implications of overlapping affective dispositions. Psychological Bulletin, 131, 260300.
Sutin, A. R., Terracciano, A., Deiana, B., Naitza, S., Ferrucci, L., Uda, M., . . . Costa, P. T. Jr. (2010). High neuroticism and low conscientiousness are associated with interleukin-6. Psychological Medicine, 40, 14851493.
Terracciano, A., Löckenhoff, C. E., Zonderman, A. B., Ferrucci, L., & Costa, P. T. Jr. (2008). Personality predictors of longevity: Activity, emotional stability, and conscientiousness. Psychosomatic Medicine, 70, 621627.
Turiano, N. A., Mroczek, D. K., Moynihan, J., & Chapman, B. P. (2013). Big 5 personality traits and interleukin-6: evidence for ‘healthy neuroticism’ in a US population sample. Brain Behavior, and Immunity, 28, 8389.
Vogelzangs, N., Beekman, A. T., de Jonge, P., & Penninx, B. W. (2013). Anxiety disorders and inflammation in a large adult cohort. Translational Psychiatry, 3, e249.
Wilson, R. S., Krueger, K. R., Gu, L. P., Bienias, J. L., Mendes de Leon, C. F., & Evans, D. A. (2005). Neuroticism, extraversion, and mortality in a defined population of older persons. Psychosomatic Medicine, 67, 841845.
Wörns, M. A., Victor, A., Galle, P. R., & Höhler, T. (2006). Genetic and environmental contributions to plasma C-reactive protein and interleukin-6 levels–a study in twins. Genes and Immunity, 7, 600605.
Wray, N. R., Birley, A. J., Sullivan, P. F., Visscher, P. M., & Martin, N. G. (2007). Genetic and phenotypic stability of measures of neuroticism over 22 years. Twin Research and Human Genetics, 10, 695702.

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The Relationship Between Neuroticism and Inflammatory Markers: A Twin Study

  • Arthur A. Sas (a1), Frühling V. Rijsdijk (a2), Johan Ormel (a3), Harold Snieder (a1) and Harriëtte Riese (a1) (a3)...

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