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The Qingdao Twin Registry: A Status Update

  • Haiping Duan (a1), Feng Ning (a2), Dongfeng Zhang (a3), Shaojie Wang (a1), Dong Zhang (a4), Qihua Tan (a5) (a6), Xiaocao Tian (a1) (a7) and Zengchang Pang (a1)...

Abstract

In 1998, the Qingdao Twin Registry was initiated as the main part of the Chinese National Twin Registry. By 2005, a total of 10,655 twin pairs had been recruited. Since then new twin cohorts have been sampled, with one longitudinal cohort of adolescent twins selected to explore determinants of metabolic disorders and health behaviors during puberty and young adulthood. Adult twins have been sampled for studying heritability of multiple phenotypes associated with metabolic disorders. In addition, an elderly twin cohort has been recruited with a focus on genetic studies of aging-related phenotypes using twin modeling and genome-wide association analysis. Cross-cultural collaborative studies have been carried out between China, Denmark, Finland, and US cohorts. Ongoing data collection and analysis for the Qingdao Twin Registry will be discussed in this article.

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Copyright

Corresponding author

address for correspondence: Zengchang Pang, Qingdao Centers for Disease Control and Prevention, Shandong Road 175, Sifang District, Qingdao, 266033, P. R. China. Email: cdcpang@126.com

References

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Alberti, K. G., & Zimmet, P. Z. (1998). Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetic Medicine, 15, 539553.
Arpawong, T. E., Sun, P., Chang, M. C., Gallaher, P., Pang, Z., Guo, Q., . . . Unger, J. (2010). Family and personal protective factors moderate the effects of adversity and negative disposition on smoking among Chinese adolescents. Substance Use & Misuse, 45, 13671389.
Beasley, R. (1998). Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The international study of asthma and allergies in childhood (ISAAC) steering committee. Lancet, 351, 12251232.
Becker, A., Busjahn, A., Faulhaber, H. D., Bahring, S., Robertson, J., Schuster, H., & Luft, F. C. (1997). Twin zygosity: Automated determination with microsatellites. The Journal of Reproductive Medicine, 42, 260266.
Chen, T. J., Ji, C. Y., & Hu, Y. H. (2009). Genetic and environmental influences on serum lipids and the effects of puberty: A Chinese twin study. Acta Paediatrica, 98, 10291036.
Chan, J. C., Malik, V., Jia, W., Kadowaki, T., Yajnik, C. S., Yoon, K. H., & Hu, F. B. (2009). Diabetes in Asia: Epidemiology, risk factors, and pathophysiology. The Journal of the American Medical Association, 301, 21292140.
China's major health challenge: Control of chronic diseases. (2011). Lancet, 378, 457.
Drake, A. J., Smith, A., Betts, P. R., Crowne, E. C., & Shield, J. P. (2002). Type 2 diabetes in obese white children. Archives of Disease in Childhood, 86, 207208.
Duan, H., Pang, Z., Zhang, D., Li, S., Kruse, T. A., Kyvik, K.O., . . . Tan, Q. (2011). Genetic and environmental dissections of sub-phenotypes of metabolic syndrome in the Chinese population: A twin-based heritability study. Obesity Facts, 4, 99104.
Duan, H. P., Pang, Z. C., Zhang, D., Wang, S. J., Zhai, Y. M., & Zhang, D. F. (2010). Heritability of serum uric acid in adolescent twins. Acta Academiae Medicinae Qingdao Universitatis, 45, 415418.
Fang, J., & Alderman, M. H. (2000). Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971–1992. National Health and Nutrition Examination Survey. The Journal of the American Medical Association, 283, 24042410.
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). ‘Mini-mental state’: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.
Ford, E. S., Li, C., Cook, S., & Choi, H. K. (2007). Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation, 115, 25262532.
Frindik, J. P., Kemp, S. F., & Sy, J. P. (1999). Effects of recombinant human growth hormone on height and skeletal maturation in growth hormone-deficient children with and without severe pretreatment bone age delay. Hormone Research, 51, 1519.
Greulich, W. W., & Pyle, S. L. (1959). Radiographic skeletal development of the hand and wrist (2nd ed.). Stanford, CA: Stanford University Press.
Gu, D., Kelly, T. N., Wu, X., Chen, J., Samet, J. M., Huang, J. F., . . . He, J. (2009). Mortality attributable to smoking in China. The New England Journal of Medicine, 360, 150159.
Invitti, C., Maffeis, C., Gilardini, L., Pontiggia, B., Mazzilli, G., Girola, A., . . . Viberti, G. C. (2006). Metabolic syndrome in obese Caucasian children: Prevalence using WHO-derived criteria and association with nontraditional cardiovascular risk factors. International Journal of Obesity, 30, 627633.
Jackson, R. W., Snieder, H., Davis, H., & Treiber, F. A. (2001). Determination of twin zygosity: A comparison of DNA with various questionnaire indices. Twin Research, 4, 1218.
LaPorte, R. E., Tajima, N., Akerblom, H. K., Berlin, N., Brosseau, J., Christy, M., . . . Neil, A. (1985). Geographic differences in the risk of insulin-dependent diabetes mellitus: The importance of registries. Diabetes Care, 8 (Suppl. 1), 101107.
Lee, M. S., Wahlqvist, M. L., Yu, H. L., & Pan, W. H. (2007). Hyperuricemia and metabolic syndrome in Taiwanese children. Asia Pacific Journal of Clinical Nutrition, 16 (Suppl. 2), 594600.
Li, L., Gao, W., Lv, J., Cao, W., Zhan, S., Yang, H., & Hu, Y. (2006). Current status of the Chinese national twin registry. Twin Research and Human Genetics, 9, 747752.
Li, Q., Hsia, J., & Yang, G. (2011). Prevalence of smoking in China in 2010. The New England Journal of Medicine, 364, 24692470.
Mooradian, A. D. (2009). Dyslipidemia in type 2 diabetes mellitus. Nature Clinical Practice Endocrinology & Metabolism, 5, 150159.
Mora, S., Boechat, M. I., Pietka, E., Huang, H. K., & Gilsanz, V. (2001). Skeletal age determinations in children of European and African descent: Applicability of the Greulich and Pyle standards. Pediatric Research, 50, 624628.
Pacifico, L., Cantisani, V., Anania, C., Bonaiuto, E., Martino, F., Pascone, R., & Chiesa, C. (2009). Serum uric acid and its association with metabolic syndrome and carotid atherosclerosis in obese children. European Journal of Endocrinology/European Federation of Endocrine Societies, 160, 4552.
Pang, Z., Bo, T., Wang, S., Peng, X., Zhang, Y., & Zhai, Y. (2003). Analysis on recruitment of monodidymus in Qingdao. China Journal of Public Health, 19, 6667.
Pang, Z., Ning, F., Unger, J., Johnson, C. A., Wang, S., Guo, Q., . . . Lee, L. (2006). The Qingdao twin registry: A focus on chronic disease research. Twin Research and Human Genetics, 9, 758762.
Pang, Z., Zhang, D., Li, S., Duan, H., Hjelmborg, J., Kruse, T. A., . . . Tan, Q. (2010). Multivariate modelling of endophenotypes associated with the metabolic syndrome in Chinese twins. Diabetologia, 53, 25542561.
Poznanski, A. K. (1984). The hand in radiologic diagnosis with gamuts and pattern profiles (2nd ed.). Philadelphia: WB Saunders.
Ren, T., Wu, D., Hu, Y., Cao, W., Zhan, S., Lv, J., . . . Li, L. (2003). The heritability analysis of the metabolic syndrome related characters in twins. Chinese Journal of Prevention and Control of Chronic Diseases, 11, 1315.
Rogol, A. D., Roemmich, J. N., & Clark, P. A. (2002). Growth at puberty. Journal of Adolescent Health, 31 (6 Suppl.), 192200.
Tang, L., Kubota, M., Nagai, A., Mamemoto, K., & Tokuda, M. (2010). Hyperuricemia in obese children and adolescents: The relationship with metabolic syndrome. Pediatric Reports, 2, e12.
Tanner, J. M., Whitehouse, R. H., & Marshall, W. A. (1975). Assessment of skeletal maturity and prediction of adult height (TW2 method). New York: Academic Press.
Trinidad, D. R., Chou, C. P., Unger, J. B., Johnson, C. A., & Li, Y. (2003). Family harmony as a protective factor against adolescent tobacco and alcohol use in Wuhan, China. Substance use & Misuse, 38, 11591171.
Unger, J. B., Lessov-Schlaggar, C. N., Pang, Z., Guo, Q., Ning, F., Gallaher, P., . . . Anderson Johnson, C. (2011). Heritability of smoking, alcohol use, and psychological characteristics among adolescent twins in Qingdao, China. Asia-Pacific Journal of Public Health, 23, 568580.
Unger, J. B., Yan, L., Shakib, S., Rohrbach, L. A., Chen, X., Qian, G., . . . Anderson Johnson, C. (2002). Peer influences and access to cigarettes as correlates of adolescent smoking: A cross-cultural comparison of Wuhan, China, and California. Preventive Medicine, 34, 476484.
Wang, L., Kong, L., Wu, F., Bai, Y., & Burton, R. (2005). Preventing chronic diseases in China. Lancet, 366, 18211824.
Warner, J. O. (1999). Worldwide variations in the prevalence of atopic symptoms: What does it all mean? Thorax, 54, S46S51.
Williams, H., Robertson, C., Stewart, A., Ait-Khaled, N., Anabwani, G., Anderson, R., . . . Weiland, M. D. Jr. (1999). Worldwide variations in the prevalence of symptoms of atopic eczema in the international study of asthma and allergies in childhood. The Journal of Allergy and Clinical Immunology, 103, 125138.
World Health Organization (WHO). 1994. Prevention of diabetes mellitus (Report of a WHO study group). World Health Organization Technical Report Series, 844, 1100.
Wu, Y., Pang, Z., Zhang, D., Jiang, W., Wang, S., Li, S., . . . Tan, Q. (2012a). A cross-sectional analysis of age and sex patterns in grip strength, tooth loss, near vision and hearing levels in Chinese aged 50-74 years. Archives of Gerontology and Geriatrics, 54, e213e220.
Wu, Y., Zhang, D., Pang, Z., Oksuzyan, A., Jiang, W., Wang, S., . . . Tan, Q. (2012b). Gender-specific patterns in age-related decline in general health among Danish and Chinese: A cross-national comparative study. Geriatrics & Gerontology International, 12, 431439.
Yang, Z., Wang, K., Li, T., Sun, W., Li, Y., Chang, Y.F., . . . LaPorte, R. E. (1998). Childhood diabetes in China. Enormous variation by place and ethnic group. Diabetes Care, 21, 525529.
Zhang, D. F., Pang, Z., Li, S., Thomassen, M., Wang, S., Jiang, W., . . . Tan, Q. (2012a). High-resolution genome-wide linkage mapping identifies susceptibility loci for BMI in the Chinese population. Obesity (Silver Spring), 20, 830833.
Zhang, D. F., Pang, Z., Li, S., Jiang, W., Wang, S., Thomassen, M., . . . Tan, Q. (2012b). Genome-wide linkage and association scans for pulse pressure in Chinese twins. Hypertension Research. Advance online publication. doi:10.1038/hr.2012.90.
Zhang, L., Qiao, Q., Tuomilehto, J., Hammar, N., Ruotolo, G., Stehouwer, C. D. A., . . . for DECODE/DECODA Study Group. (2009). The impact of dyslipidaemia on cardiovascular mortality in individuals without a prior history of diabetes in the DECODE Study. Atherosclerosis. 206, 298302.
Zhu, B. P., Liu, M., Wang, S. Q., He, G. Q., Chen, D. H., Shi, J. H., . . . Shang, J. Z. (1992). Cigarette smoking among junior high school students in Beijing, China, 1988. International Journal of Epidemiology, 21, 854861.
Zung, W. W. (1965). A self-rating depression scale. Archives of General Psychiatry, 12, 6370.
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Twin Research and Human Genetics
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