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Pre- and Perinatal Characteristics Associated with Apgar Scores in a Review and in a New Study of Dutch Twins

  • Veronika V. Odintsova (a1) (a2) (a3), Conor V. Dolan (a1), Catharina E. M. van Beijsterveldt (a1), Eveline L. de Zeeuw (a1), Jenny van Dongen (a1) and Dorret I. Boomsma (a1)...

Abstract

A literature review was carried out to identify pre and perinatal characteristics associated with variation in Apgar scores in population-based studies. The parameters identified in the literature search were included in the classical twin design study to estimate effects of pre and perinatal factors shared and nonshared by twins and to test for a contribution of genetic factors in 1- and 5-min Apgar scores in a large sample of Dutch monozygotic (MZ) and dizygotic (DZ) twins. The sample included MZ and DZ twins (N = 5181 pairs) recruited by the Netherlands Twin Register shortly after birth, with data on prenatal characteristics and Apgar scores at first and/or fifth minutes. The ordinal regression and structural equation modeling were used to analyze the effects of characteristics identified in the literature review and to estimate genetic and nongenetic variance components. The literature review identified 63 papers. Consistent with the review, we observed statistically significant effects of birth order, zygosity and gestational age (GA) for 1- and 5-min Apgar scores of both twins. Apgar scores are higher in first-born versus second-born twins and DZ first-born versus MZ first-born twins. Birth weight had an effect on the 5-min Apgar of the first born. Fetal presentation and mode of delivery had different effects on Apgar scores of first- and second-born twins. Parental characteristics and chorionicity did not have significant main effects on Apgar scores. The MZ twins’ Apgar correlations equaled the DZ Apgar correlations. Our analyses suggest that individual differences in 1- and 5-min Apgar scores are attributable to shared and nonshared pre and perinatal factors, but not to genotypic factors of the newborns. The main predictors of Apgar scores are birth order, zygosity, GA, birth weight, mode of delivery and fetal presentation.

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This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http://creativecommons.org/licenses/by-nc-sa/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is included and the original work is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use.

Corresponding author

*Author for correspondence: Veronika V. Odintsova, Email: v.v.odintsova@vu.nl

References

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Pre- and Perinatal Characteristics Associated with Apgar Scores in a Review and in a New Study of Dutch Twins

  • Veronika V. Odintsova (a1) (a2) (a3), Conor V. Dolan (a1), Catharina E. M. van Beijsterveldt (a1), Eveline L. de Zeeuw (a1), Jenny van Dongen (a1) and Dorret I. Boomsma (a1)...

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