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The Older Finnish Twin Cohort — 45 Years of Follow-up

  • Jaakko Kaprio (a1) (a2), Sailalitha Bollepalli (a1), Jadwiga Buchwald (a1), Paula Iso-Markku (a1) (a3), Tellervo Korhonen (a1), Vuokko Kovanen (a4), Urho Kujala (a5), Eija K. Laakkonen (a4), Antti Latvala (a1), Tuija Leskinen (a6), Noora Lindgren (a7), Miina Ollikainen (a1), Maarit Piirtola (a1), Taina Rantanen (a4), Juha Rinne (a7) (a8), Richard J. Rose (a9), Elina Sillanpää (a4), Karri Silventoinen (a2) (a10), Sarianna Sipilä (a4), Anne Viljanen (a4), Eero Vuoksimaa (a1) and Katja Waller (a5)...


The older Finnish Twin Cohort (FTC) was established in 1974. The baseline survey was in 1975, with two follow-up health surveys in 1981 and 1990. The fourth wave of assessments was done in three parts, with a questionnaire study of twins born during 1945–1957 in 2011–2012, while older twins were interviewed and screened for dementia in two time periods, between 1999 and 2007 for twins born before 1938 and between 2013 and 2017 for twins born in 1938–1944. The content of these wave 4 assessments is described and some initial results are described. In addition, we have invited twin-pairs, based on response to the cohortwide surveys, to participate in detailed in-person studies; these are described briefly together with key results. We also review other projects based on the older FTC and provide information on the biobanking of biosamples and related phenotypes.

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This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (, which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

Author for correspondence: Jaakko Kaprio, Email:


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