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The Minnesota Center for Twin and Family Research Genome-Wide Association Study

  • Michael B. Miller (a1), Saonli Basu (a2), Julie Cunningham (a3), Eleazar Eskin (a4), Steven M. Malone (a1), William S. Oetting (a5), Nicholas Schork (a6), Jae Hoon Sul (a4), William G. Iacono (a1) and Matt McGue (a1) (a7)...

Abstract

As part of the Genes, Environment and Development Initiative, the Minnesota Center for Twin and Family Research (MCTFR) undertook a genome-wide association study, which we describe here. A total of 8,405 research participants, clustered in four-member families, have been successfully genotyped on 527,829 single nucleotide polymorphism (SNP) markers using Illumina's Human660W-Quad array. Quality control screening of samples and markers as well as SNP imputation procedures are described. We also describe methods for ancestry control and how the familial clustering of the MCTFR sample can be accounted for in the analysis using a Rapid Feasible Generalized Least Squares algorithm. The rich longitudinal MCTFR assessments provide numerous opportunities for collaboration.

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Copyright

Corresponding author

address for correspondence: Michael B. Miller, Department of Psychology/Elliott Hall, University of Minnesota, Minneapolis, MN 55455. E-mail: mbmiller@umn.edu

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