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Genetic and Environmental Risk for Major Depression in African-American and European-American Women

  • Alexis E. Duncan (a1) (a2) (a3), Melissa A. Munn-Chernoff (a2) (a3), Darrell L. Hudson (a1), Michaela A. Eschenbacher (a4), Arpana Agrawal (a2) (a3), Julia D. Grant (a2) (a3), Elliot C. Nelson (a2) (a3), Mary Waldron (a2) (a5), Anne L. Glowinski (a2) (a3), Carolyn E. Sartor (a2) (a6), Kathleen K. Bucholz (a2) (a3), Pamela A. F. Madden (a2) (a3) and Andrew C. Heath (a2) (a3)...

Abstract

It is unknown whether there are racial differences in the heritability of major depressive disorder (MDD) because most psychiatric genetic studies have been conducted in samples comprised largely of white non-Hispanics. To examine potential differences between African-American (AA) and European-American (EA) young adult women in (1) Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) MDD prevalence, symptomatology, and risk factors, and (2) genetic and/or environmental liability to MDD, we analyzed data from a large population-representative sample of twins ascertained from birth records (n = 550 AA and n = 3226 EA female twins) aged 18–28 years at the time of MDD assessment by semi-structured psychiatric interview. AA women were more likely to have MDD risk factors; however, there were no significant differences in lifetime MDD prevalence between AA and EA women after adjusting for covariates (odds ratio = 0.88, 95% confidence interval [CI]: 0.67–1.15). Most MDD risk factors identified among AA women were also associated with MDD at similar magnitudes among EA women. Although the MDD heritability point estimate was higher among AA women than EA women in a model with paths estimated separately by race (56%, 95% CI: 29–78% vs. 41%, 95% CI: 29–52%), the best fitting model was one in which additive genetic and non-shared environmental paths for AA and EA women were constrained to be equal (A = 43%, 33–53% and E = 57%, 47–67%). In spite of a marked elevation in the prevalence of environmental risk exposures related to MDD among AA women, there were no significant differences in lifetime prevalence or heritability of MDD between AA and EA young women.

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Copyright

Corresponding author

ADDRESS FOR CORRESPONDENCE: Alexis E. Duncan, George Warren Brown School of Social Work, Washington University, One Brookings Drive, Campus Box 1196, St. Louis, MO 63130, USA. E-mail: aduncan@wustl.edu

References

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Amato, P. R., & Keith, B. (1991). Parental divorce and the well-being of children: A meta-analysis. Psychological Bulletin, 110, 2646.
Anda, R. F., Whitfield, C. L., Felitti, V. J., Chapman, D., Edwards, V. J., Dube, S. R., & Williamson, D. F. (2002). Adverse childhood experiences, alcoholic parents, and later risk of alcoholism and depression. Psychiatric Services, 53, 10011009.
Bierut, L. J., Heath, A. C., Bucholz, K. K., Dinwiddie, S. H., Madden, P. A. F., Statham, D. J., . . . Martin, N. G. (1999). Major depressive disorder in a community-based twin sample: Are there different genetic and environmental contributions for men and women? Archives of General Psychiatry, 56, 557563.
Black, S., & Klein, D. N. (2012). Early menarcheal age and risk for later depressive symptomatology: The role of childhood depressive symptoms. Journal of Youth and Adolescence, 41, 11421150.
Bucholz, K. K., Cadoret, R., Cloninger, C., Dinwiddie, S. H., Hesselbrock, V. M., Nurnberger, J. I., . . . Schuckit, M. A. (1994). A new, semi-structured psychiatric interview for use in genetic linkage studies: A report of the reliability of the SSAGA. Journal of Studies on Alcohol, 55, 149158.
Caspi, A., Sugden, K., Moffitt, , Terrie, E., Taylor, A., Craig, I. W., Harrington, H., . . . Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386389.
Dunlop, D. D., Song, J., Lyons, J. S., Manheim, L. M., & Chang, R. W. (2003). Racial/ethnic differences in rates of depression among preretirement adults. American Journal of Public Health, 93, 1951952.
Eaves, L. J., Eysenck, H. J., & Martin, N. G. (1989). Genes, culture and personality: An empirical approach. London: Academic Press.
Gee, G. C., Walsemann, K. M., & Brondolo, E. (2012). A life course perspective on how racism may be related to health inequities. American Journal of Public Health, 102, 967974.
Glowinski, A. L., Madden, P. A., Bucholz, K. K., Lynskey, M. T., & Heath, A. C. (2003). Genetic epidemiology of self-reported lifetime DSM-IV major depressive disorder in a population-based twin sample of female adolescents. Journal of Child Psychology and Psychiatry, 44, 988996.
Hasin, D. S., Goodwin, R. D., Stinson, F. S., & Grant, B. F. (2005). Epidemiology of major depressive disorder: Results from the National Epidemiologic Survey on Alcoholism and Related Conditions. Archives of General Psychiatry, 62, 10971106.
Heath, A. C., Howells, William, Bucholz, K. K., Glowinski, A. L., Nelson, Elliot, C., & Madden, P. A. F. (2002). Ascertainment of a Mid-Western US female adolescent twin cohort for alcohol studies: Assessment of sample representativeness using birth record data. Twin Research, 5 (2), 107112.
Heath, A. C., Madden, P. A. F., Grant, J. D., McLaughlin, T. L., Todorov, A. A., & Bucholz, K. K. (1999). Resiliency factors protecting against teenage alcohol use and smoking: Influences of religion, religious involvement and values, and ethnicity in the Missouri Adolescent Female Twin Study. Twin Research, 2, 145155.
Heath, A. C., & Martin, N. G. (1993). Genetic models for the natural history of smoking: Evidence for a genetic influence on smoking persistence. Addictive Behaviors, 18, 1934.
Hesselbrock, M. N., Mesa, C. E., Bucholz, K. K., Schuckit, M. A., & Hesselbrock, V. M. (1999). A validity study of the SSAGA: A comparison with the SCAN. Addiction, 94, 13611370.
Jackson, J. S., Knight, K. M., & Rafferty, M. A. (2010). Race and unhealthy behaviors: Chronic stress, the HPA axis, and physical and mental health disparities over the life course. American Journal of Public Health, 200, 9333939.
Joinson, C., Heron, J., Lewis, G., Croudace, T., & Araya, R. (2011). Timing of menarche and depressive symptoms in adolescent girls from a UK cohort. British Journal of Psychiatry, 198, 1723.
Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68, 444454.
Kendler, K. S., Gatz, M., Gardner, Charles, O., & Pedersen, N. L. (2006). A Swedish National Twin Study of lifetime major depression. American Journal of Psychiatry, 163, 109114.
Kendler, K. S., & Prescott, C. A. (1999). A population-based twin study of lifetime major depression in men and women. Archives of General Psychiatry, 56, 3944.
Kendler, K. S., Pedersen, N. L., Neale, M. C., & Mathe, A. A. (1995a). A pilot Swedish twin study of affective illness including hospital- and population-ascertained subsamples: Results of model fitting. Behavior Genetics, 25, 217232.
Kendler, K. S., Walters, E.E., Neale, M. C., Kessler, R. C., Heath, A. C., & Eaves, L. J. (1995b). The structure of the genetic and environmental risk factors for six major psychiatric disorders in women: Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism. Archives of General Psychiatry, 52, 374383.
Kessler, R. C., Berglund, P. A., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Wang, P. S. (2003). The epidemiology of major depressive disorder: Results from the National Comorbidity Survey Replication (NCS-R). Journal of the American Medical Association, 289, 30953105.
Kessler, R. C., Berglund, P. A., Demler, O., Jin, R., & Walters, E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62, 593602.
Kessler, R. C., Sonnega, A., Evelyn, B., Hughes, M., & Nelson, C. B. (1995). Post-traumatic stress disorder in the National Comorbidity Survey. Archives of General Psychiatry, 52, 10481060.
Keyes, C. L. M. (2009). The black-white paradox in health: Flourishing in the face of social inequality and descrimination. Journal of Personality, 77, 16771706.
Keyes, K. M., Barnes, D. M., & Bates, L. M. (2011). Stress, coping and depression: Testing a new hypothesis in a prospectively studied general population sample of US-born Whites and Blacks. Social Science and Medicine, 72, 650659.
Lyons, M. J., Eisen, S. A., Goldberg, J., True, W. R., Lin, N., Meyer, Joanne, M., . . . Tsuang, M. T. (1998). A registry-based twin study of depression in men. Archives of General Psychiatry, 55, 468.
McGuffin, P., Katz, R., Watkins, S., & Rutherford, J. (1996). A hospital-based twin register of the heritability of DSM-IV unipolar depression. Archives of General Psychiatry, 53, 129136.
Molnar, B. E., Buka, S. L., & Kessler, Ronald, C. (2001). Child sexual abuse and subsequent psychopathology: Results from the National Comorbidity Survey. American Journal of Public Health, 91, 753760.
Munafo, M. R. (2012). The serotonin transporter gene and depression. Depression and Anxiety, 29, 915917.
Neale, M. C., Boker, S. M., Xie, G., & Maes, H. H. (2006). Mx: Statistical modeling (7th ed.). Richmond, VA: Department of Psychiatry, Medical College of Virginia.
Neale, M. C., & Cardon, L. R. (1992). Methodology for genetic studies of twins and families. Dordrecht, Netherlands: Kluwer.
Nelson, E. C., Heath, A. C., Madden, P. A. F., Cooper, M. Lynne, Dinwiddie S. H., Bucholz, K. K., . . . Martin, N. G. (2002). Association between self-reported childhood sexual abuse and adverse psychosocial outcomes: Results from a twin study. Archives of General Psychiatry, 59, 139145.
Nichols, R. C., & Bilbro, W. C. (1966). Diagnosis of twin zygosity. Acta Genetica et Statistica Medica, 16, 165275.
Rao, J. N. K., & Scott, A. J. (1984). On chi-squared tests for multiway contingency tables with cell proportions estimated from survey data. Annals of Statistics, 12, 4660.
Riolo, S. A., Nguyen, T. A., Greden, J. F., & King, C. A. (2004). Prevalence of depression by race/ethnicity: Findings from the National Health and Nutrition Examination Survey III. American Journal of Public Health, 95, 998999.
Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L. J., Hoh, J., . . . Merikangas, K. R. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression. Journal of the American Medical Association, 301, 24622471.
Sartor, C. E., Waldron, M., Duncan, A. E., Grant, J. D., McCutcheon, V. V., Nelson, E. C., . . . Heath, A. C. (2013). Childhood sexual abuse and early substance use in adolescent girls: The role of common risk factors and familial influences. Addiction, 108, 9931000.
Sham, P. (1998). Statistics in human genetics. London: Edward Arnold.
Shuey, K. M., & Willson, A. E. (2008). Cumulative disadvantage and Black–White disparities in life-course health trajectories. Research on Aging, 30, 200225.
StataCorp. (2005). Stata statistical software: Release 9. College Station, TX: StataCorp LP.
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000). Genetic epidemiology of major depression: Review and meta-analysis. American Journal of Psychiatry, 157, 15521562.
Suthers, K. M., Gatz, M., & Fiske, A. (2004). Screening for depression: A comparative analysis of the 11-Item CES-D and the CIDI-SF. Journal of Mental Health and Aging, 10, 209219.
Waldron, M., Bucholz, K. K., Lynskey, M. T., Madden, P. A. F., & Heath, A. C. (2013). Alcoholism and timing of separation in parents: Findings in a Midwestern birth cohort. Journal of Studies on Alcohol and Drugs, 74, 377–348.
Walsemann, K. M., Gee, G. C., & Geronimus, A. T. (2009). Ethnic differences in trajectories of depressive symptoms: Disadvantage in family background, high school experiences and adult characteristics. Journal of Health and Social Behavior, 50, 8298.
Walsemann, K. M., Geronimus, A. T., & Gee, G. C. (2008). Accumulating disadvantage over the life course: Evidence from a longitudinal study investigating the relationship between educational advantage in youth and health in middle age. Research on Aging, 30, 169199.
Whitfield, K. E., Edwards, C. L., Brandon, D. T., & McDougald, C. (2008). Genetic and environmental influences on depressive symptoms by age and gender in African-American twins. Aging & Mental Health, 12, 221227.
Widom, C. S., DuMont, K., & Czaja, S. J. (2007). A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Archives of General Psychiatry, 64, 4956.
Williams, D. R., Gonzalez, H. M., Neighbors, H., Nesse, R., Abelson, J. M., Sweetman, J., & Jackson, J. S. (2007). Prevalence and distribution of major depressive disorder in African-Americans, Carribean Blacks, and Non-Hispanic Whites: Results from the National Survey of American Life. Archives of General Psychiatry, 64, 305315.
Wittchen, H. U., & Uhmann, S. (2010). The timing of depression: An epidemiological perspective. Medicographia, 32, 115125.

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