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Estimation of Prevalence of DSM-IV and Latent Class-Defined ADHD Subtypes in a Population-Based Sample of Child and Adolescent Twins

Published online by Cambridge University Press:  21 February 2012

Rosalind J. Neuman*
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America. roz@gretta.wustl.edu
Nantawat Sitdhiraksa
Affiliation:
Mahidol University, Faculty of Medicine, Siriraj Hospital, Salaya, Phuttamonthon District, Nakhon Pathom, Thailand.
Wendy Reich
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Ted H.-C. Ji
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Cynthia A. Joyner
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Ling-Wei Sun
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Richard D. Todd
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
*
*Address for correspondence: Rosalind J. Neuman, Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Avenue, St. Louis, MO 63110–1093, USA.

Abstract

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The goal of this study is to determine the prevalence and age of onset of Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSMIV; American Psychiatric Association, 1994) and latent class-derived attention deficit/hyperactivity disorder (ADHD) subtypes in a population-based twin sample of boys and girls. Missouri birth records identified families with a twin pair 7 to 18 years of age. Telephone screening interviews for ADHD symptoms were completed for 5007 families. Diagnostic assessments were administered to 564 families with at least one twin meeting screening criteria, plus 183 control families. Prevalence and age of onset for both ADHD nosologies were calculated by sex and zygosity from parent report data. The prevalence of any DSM-IV ADHD was 6.2% overall, 7.4% in boys and 3.9% in girls. The inattentive subtype was most common in boys; the combined subtype was most common in girls. The mean age of onset of symptoms in children with any DSM-IV ADHD was 3.5 years, with no significant differences between boys and girls. Prevalences of latent class defined ADHD subtypes also varied by sex with the severe inattentive and combined classes more common in boys than girls. The age of onset of symptoms did not differ between boys and girls but were higher than in the DSM-IV subtypes. Findings in this twin sample showed that clinically significant ADHD, defined by either DSM-IV or latent class criterion, has an early age of onset and is more common in boys than girls. As clinical samples are most commonly composed of male combined subtypes, the inattentive subtype of both sexes in the general population is an under- treated segment of the general population.

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Copyright © Cambridge University Press 2005
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Estimation of Prevalence of DSM-IV and Latent Class-Defined ADHD Subtypes in a Population-Based Sample of Child and Adolescent Twins
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Estimation of Prevalence of DSM-IV and Latent Class-Defined ADHD Subtypes in a Population-Based Sample of Child and Adolescent Twins
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Estimation of Prevalence of DSM-IV and Latent Class-Defined ADHD Subtypes in a Population-Based Sample of Child and Adolescent Twins
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