We present a heuristic framework for attacking the undecidable termination problem of logic programs, as an alternative to current termination/nontermination proof approaches. We introduce an idea of termination prediction, which predicts termination of a logic program in case that neither a termination nor a non-termination proof is applicable. We establish a necessary and sufficient characterization of infinite (generalized) SLDNF-derivations with arbitrary (concrete or moded) queries, and develop an algorithm that predicts termination of general logic programs with arbitrary nonfloundering queries. We have implemented a termination prediction tool and obtained quite satisfactory experimental results. Except for five programs which break the experiment time limit, our prediction is 100% correct for all 296 benchmark programs of the Termination Competition 2007, of which 18 programs cannot be proved by any of the existing state-of-the-art analyzers like AProVE07, NTI, Polytool, and TALP.