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Surface-enhanced Raman spectra of hemoglobin for esophageal cancer diagnosis

Published online by Cambridge University Press:  03 March 2014

Xue Zhou ,
Zhenqi Diao ,
Chunzhen Fan ,
Huiqiang Guo ,
Yang Xiong  and
Weiyue Tang
Xue Zhou*
Affiliation:
College of Physical Science and Engineering, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Zhenqi Diao
Affiliation:
College of Physical Science and Engineering, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Chunzhen Fan
Affiliation:
College of Physical Science and Engineering, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Huiqiang Guo
Affiliation:
College of Physical Science and Engineering, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Yang Xiong
Affiliation:
Application Institute of Spectroscopy Technology, Chuxiong Normal University, Chuxiong, Yunan 675000, P.R. China
Weiyue Tang
Affiliation:
College of Physical Science and Engineering, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
*
ae-mail: 185226112@qq.com
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Abstract

Surface-enhanced Raman scattering (SERS) spectra of hemoglobin from 30 esophageal cancer patients and 30 healthy persons have been detected and analyzed. The results indicate that, there are more iron ions in low spin state and less in high for the hemoglobin of esophageal cancer patients than normal persons, which is consistent with the fact that it is easier to hemolyze for the blood of cancer patients. By using principal component analysis (PCA) and discriminate analysis, we can get a three-dimensional scatter plot of PC scores from the SERS spectra of healthy persons and cancer patients, from which the two groups can be discriminated. The total accuracy of this method is 90%, while the diagnostic specificity is 93.3% and sensitivity is 86.7%. Thus SERS spectra of hemoglobin analysis combined with PCA may be a new technique for the early diagnose of esophageal cancer.

Type
Research Article
Information
The European Physical Journal - Applied Physics , Volume 65 , Issue 3 , March 2014 , 30701
Copyright
© EDP Sciences, 2014

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