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Effect of deep brain stimulation on amplitude and frequency characteristics of rest tremor in Parkinson’s disease

Published online by Cambridge University Press:  12 April 2006

Anne Beuter
Affiliation:
Cognitive Neuroscience Centre (DS-5749), University of Quebec at Montreal, P.O. Box 8888, Station Centre Ville, Montréal Que., Canada H3C 3P8 Physiology Department, Centre for Nonlinear Dynamics in Physiology and Medicine, McGill University, 3655 rue Drummond, Montréal, Que., Canada H3G 1Y6 Service d’Explorations Fonctionnelles du Système Nerveux, CHU de Bordeaux, Hôpital du Levêque, 33600 Pessac, France
Michèle Titcombe
Affiliation:
Cognitive Neuroscience Centre (DS-5749), University of Quebec at Montreal, P.O. Box 8888, Station Centre Ville, Montréal Que., Canada H3C 3P8 Physiology Department, Centre for Nonlinear Dynamics in Physiology and Medicine, McGill University, 3655 rue Drummond, Montréal, Que., Canada H3G 1Y6
François Richer
Affiliation:
Cognitive Neuroscience Centre (DS-5749), University of Quebec at Montreal, P.O. Box 8888, Station Centre Ville, Montréal Que., Canada H3C 3P8
Christian Gross
Affiliation:
Service d’Explorations Fonctionnelles du Système Nerveux, CHU de Bordeaux, Hôpital du Levêque, 33600 Pessac, France
Dominique Guehl
Affiliation:
Service d’Explorations Fonctionnelles du Système Nerveux, CHU de Bordeaux, Hôpital du Levêque, 33600 Pessac, France

Abstract

The effect of chronic high frequency deep brain stimulation (DBS) on rest tremor was investigated in subjects with Parkinson’s disease (PD). Eight PD subjects with high amplitude tremor (Group 1) and eight PD subjects with low amplitude tremor (Group 2, used as a reference group) were examined by a clinical neurologist and tested with a velocity laser to quantify time and frequency domain characteristics of tremor. Possible rebound effects in rest tremor when DBS was stopped for 60 min were also explored. Participants received DBS of the internal globus pallidus (GPi) (n = 7), the subthalamic nucleus (STN) (n = 6) or the ventrointermediate nucleus of the thalamus (Vim) (n = 3). Tremor was recorded with a velocity laser under two conditions of DBS (on-off) and two conditions of medication (L-Dopa on-off). Correlations between clinical and experimental results for tremor amplitude was 0.70 with no medication and no stimulation. In Group 1, DBS decreased tremor amplitude but also increased spectral concentration and median frequency significantly. Under medication, the changes in tremor with and without stimulation were not statistically significant (Group 1). When stimulation was stopped for 60 min, a rebound in tremor amplitude was observed and median frequency remained stable in Group 1. None of the comparisons examined produced significant effects in Group 2. Taken together, these results suggest that beyond its effect on tremor amplitude DBS acted also on tremor frequency and did not modify tremor characteristics in subjects with low amplitude tremor.

Type
Research Article
Copyright
2001 Elsevier Science Ltd

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