Massive stars (M ≥ 10M⊙) and supernova are found to be the possible sites for explosive thermonuclear burning. When a massive star collapses, shock waves moving through various convective zones produces explosive situations. The gravitational collapse of a helium exhausted core leads to violent instabilities. The reaction 12C(α, γ)16O is being studied under this condition. Recently it has been found that the coefficients in the semi-empirical mass formula are temperature dependent. Assuming the volume and surface binding to be effective, the nuclear masses, Q values, and reaction rates are calculated. Carbon alpha reaction is found to attain explosive proportion at the high temperature range considered here.