I am going to use this opportunity to make some very general remarks. I believe we are about to enter an era that is very different from those we have experienced before, and is probably closest to what those of us who have been around long enough experienced in the 1970s. That was a time of explosive expansion in space astronomy and astrophysics. The intervening two decades have seen major advances in many specific areas, but, since the 1970s period, progress has been more episodic, triggered by the occasional appearance of some new observational tool, new computational tool, or theoretical insight.