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Putative intraovarian regulators

Published online by Cambridge University Press:  03 June 2009

Eli Y Adashi  and
Richard M Rohan
Eli Y Adashi*
Affiliation:
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Richard M Rohan
Affiliation:
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, Maryland, USA
*
Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, 405 W. Redwood Street, Third Floor, Baltimore MD 21201, USA.
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Extract

Ovarian folliculogenesis is an exponential process marked by dramatic proliferation and differentiation of the somatic and germ cell elements of the follicle. Although the central roles of gonadotropins and of gonadal steroids in this explosive agenda are well accepted, the variable fate of follicles afforded comparable gonadotropic stimulation suggests the existence of additional intraovarian modulatory systems. Accordingly, consideration must be given to another set (or sets) of regulatory principles that may provide these missing modulatory loops. The work of multiple contributors favors the hypothesis that these modulatory loops are comprised of a host of peptidergic principles which engage in situ in the modulation of ovarian growth and function. In its capacity as an intraovarian regulator, a given agent may be acting independently of, as an amplifier of, as an attenuator of, or even as a mediator of, gonadotropin action. Together, gonadotropins, steroids, and locally derived peptidergic principles form a triad that modulates the growth and differentiation of ovarian follicles (Figure 1).

Type
Articles
Information
Reproductive Medicine Review , Volume 5 , Issue 2 , July 1996 , pp. 65 - 71
Copyright
Copyright © Cambridge University Press 1996

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References

1Efstratiadis, A. IGFs and dwarf mice: genetic and epigenetic control of embryonic growth. In: Sizonenko, PC, Aubert, ML, Vassali, J-D eds. Developmental endocrinology, frontiers in endocrinology, Volume 6. Rome: Ares-Serono Symposia Publications, 1994: 27–43.Google Scholar
2Adashi, EY, Resnick, CE, Hurwitz, A et al. Insulin-like growth factors: the ovarian connection. Hum Reprod 1991; 6: 1213–19.CrossRefGoogle ScholarPubMed
3Hernandez, ER, Roberts, CT Jr, LeRoith, D, Adashi, EY. Rat ovarian insulin-like growth factor I (IGF-I) gene expression is granulosa cellselective: 5′-untranslated mRNA variant representation and hormonal regulation. Endocrinology 1989; 125: 572–74.CrossRefGoogle Scholar
4Oliver, JE, Aitman, TJ, Powell, JF, Wilson, CA, Clayton, RN. Insulin-like growth factor I gene expression in the rat ovary is confined to the granulosa cells of developing follicles. Endocrinology 1989; 124: 2671–79.CrossRefGoogle Scholar
5Adashi, EY, Resnick, CE, Rosenfeld, RG. Insulinlike growth factor-I (IGF-I) and IGF-II hormonal action in cultured rat granulosa cells: mediation via type I but not type II IGF receptors. Endocrinology 126: 216–22.CrossRefGoogle Scholar
6Davoren, JB, Kasson, BG, Li, CH, Hsueh, AJW. Specific insulin-like growth factor (IGF) I- and H-binding sites on rat granulosa cells. Endocrinology 1986; 119: 2155–62.CrossRefGoogle Scholar
7Carr, JF, Fan, J, Azzarello, J, Rosenfield, RL. Insulin-like growth factor-I enhances luteinizing hormone binding to rat ovarian theca-interstitial cells. J Clin Invest 1990; 86: 560–65.CrossRefGoogle Scholar
8Hernandez, ER, Resnick, CE, Svoboda, ME, VanWyk, JJ, Payne, DW, Adashi, EY. Somatomedin-C/insulin-like growth factor-I (SM- C/IGF-I) as an enhancer of androgen biosynthesis by cultured rat ovarian cells. Endocrinology 1988; 122: 1603–13.CrossRefGoogle Scholar
9Erickson, GF, Nakatani, A, Ling, N, Shimasaki, S. Cyclic changes in insulin-like growth factor- binding protein-4 messenger ribonucleic acid in the rat ovary. Endocrinology 1992; 130: 625–36.Google ScholarPubMed
10Adashi, EY, Resnick, CE, Ricciarelli, E et al. Local tissue modification of follicle stimulating hormone action. In: Genazzani, AR, Petraglia, F eds. Hormones in gynecological endocrinology. Carnforth Lanes, UK: Parthenon, 1992; 255–61.Google Scholar
11Gospodarowicz, D, Ill, CR, Birdwell, CR. Effects of fibroblast and epidermal growth factors on ovarian cell proliferation in vitro. I. Characterization of the response of granulosa cells to FGF and EGF. Endocrinology 1977; 100: 1108–20.CrossRefGoogle ScholarPubMed
12May, JV, Schomberg, DW. The potential relevance of epidermal growth factor and transforming growth factor-α to ovarian physiology. Semin Reprod Endocrinol 1989; 7: 1–11.CrossRefGoogle Scholar
13Bendell, JJ, Dorrington, JH. Epidermal growth factor influences growth and differentiation of rat granulosa cells. Endocrinology 1990; 127: 533–40.Google Scholar
14Kudlow, JE, Kobrin, MS, Purchio, AF et al. Ovarian transforming growth factor-α gene expression: immunohistochemical localization to the theca-interstitial cells. Endocrinology 1987; 121: 1577–79.Google Scholar
15Erickson, GF, Case, E. Epidermal growth factor antagonizes ovarian theca-interstitial cytodifferentiation. Mol Cell Endocrinol 1983; 31: 71–6.CrossRefGoogle ScholarPubMed
16DePaolo, LV, Bicsak, TA, Erickson, GF, Shimasaki, S, Ling, N. Follistatin and activin: a potential intrinsic regulatory system within diverse tissues. Proc Soc Exp Biol Med 1991; 198: 500–12.CrossRefGoogle ScholarPubMed
17Murata, M, Eto, Y, Shibai, H, Sakai, M, Muramatsu, M. Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain. Proc Natl Acad Sci USA 1988; 85: 2434–38.CrossRefGoogle ScholarPubMed
18Smith, JC, Price, BM, Van Nimmen, K, Huylebroeck, D. Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A. Nature; 345: 729–31.CrossRefGoogle Scholar
19Mathews, LS, Vale, WW. Expression cloning of an activin receptor a predicted transmembrane serine kinase. Cell 1991; 65: 973–82.CrossRefGoogle ScholarPubMed
20Attisano, L, Wrana, JL, Cheifetz, S, Massague, J. Novel activin receptors: distinct genes and alternative messenger RNA splicing generate a repertoire of serine threonine kinase receptors. Cell 1992; 68: 97–108.CrossRefGoogle ScholarPubMed
21Miro, F, Smyth, CD, Hillier, SG. Developmentrelated effects of recombinant activin on steroid synthesis in rat granulosa cells. Endocrinology 1991; 129: 3388–94.Google Scholar
22Findlay, JK, Sai, X, Shukovski, L. Role of inhibinrelated peptides as intragonadal regulators. Reprod Fertil Dev 1990; 2: 205–18.CrossRefGoogle ScholarPubMed
23Hsueh, AW, Dahl, KD, Vaughan, J et al. Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis. Proc Natl Acad Sci USA 1987; 84: 5082–86.CrossRefGoogle ScholarPubMed
24Hillier, SG. Regulatory functions for inhibin and activin in human ovaries. J Endocrinol 1991; 131: 171–75.CrossRefGoogle ScholarPubMed
25Nakamura, T, Takio, K, Eto, Y, Shibai, H, Titani, K, Sugino, H. Activin-binding protein from rat ovary is follistatin. Science 1990; 247: 836–38.CrossRefGoogle ScholarPubMed
26Nakatani, A, Shimasaki, S, DePaolo, LV, Erickson, GF, Ling, N. Cyclic changes in follistatin messenger ribonucleic acid and its protein in the rat ovary during the estrous cycle. Endocrinology 1991; 129: 603–11.CrossRefGoogle ScholarPubMed
27Adashi, EY. The potential relevance of cytokines to ovarian physiology: the emerging role of resident ovarian cells of the white blood cell series. Endocr Rev 1990; 11: 454–64.Google Scholar
28Dinarello, CA. Interleukin-1 and its biologically related cytokines. Adv Immunol 1989; 44: 153–205.CrossRefGoogle ScholarPubMed
29Hurwitz, A, Ricciarelli, E, Botero, L, Rohan, RM, Hernandez, ER, Adashi, EY. Endocrine- and autocrine-mediated regulation of rat ovarian (theca-interstitial) interleukin-1β gene expression: gonadotropin-dependent preovulatory acquisition. Endocrinology 1991; 129: 3427–29.Google Scholar
30Hurwitz, A, Loukides, J, Ricciarelli, E et al. The human intraovarian interleukin-I (IL-I) system: highly-compartmentalized and hormonally- dependent regulation of the genes encoding IL-I, its receptor, and its receptor antagonist. J Clin Invest 1992; 89: 1746–54.CrossRefGoogle Scholar
31Kokia, E, Hurwitz, A, Ricciarelli, E et al. Interleukin-1 stimulates ovarian prostaglandin biosynthesis: evidence for heterologous contact-independent cell-cell interaction. Endocrinology 1992; 130: 3095–97.CrossRefGoogle ScholarPubMed
32Knecht, M, Feng, P, Catt, KJ. Transforming growth factor-β: autocrine, paracrine, and endocrine effects in ovarian cells. Semin Reprod Endocrinol 1898; 7: 12–20.CrossRefGoogle Scholar
33Hernandez, ER, Purchio, AF, Dhamarajan, AM, Payne, DW, Hurwitz, A, Adashi, EY. Transforming growth factor-β1 (TGFβ1) inhibits ovarian androgen production: gene expression, cellular localization, mechanism(s), and site(s) of action. Endocrinology 1990; 127: 3239–51.CrossRefGoogle Scholar
34Wagner, JA. The fibroblast growth factors: an emerging family of neural growth factors. Curr Top Microbiol Immunol: 1990; 1165: 95–118.Google Scholar
35Adashi, EY, Resnick, CE, Croft, CS, Gospodarowicz, D. Basic fibroblast growth factor as a regulator of ovarian granulosa cell differentiation: a novel non-mitogenic role. Mol Cell Endocrinol 1988; 55: 7–14.CrossRefGoogle ScholarPubMed
36LaPolt, PS, Yamoto, M, Veljkovic, M et al. Basic fibroblast growth factor induction of granulosa cell tissue-type plasminogen activator expression and oocyte maturation: potential role as a paracrine ovarian hormone. Endocrinology 1990; 127: 2357–63.CrossRefGoogle ScholarPubMed
37Hurwitz, A, Hernandez, ER, Resnick, CE, Packman, JN, Payne, DW, Adashi, EY. Basic fibroblast growth factor inhibits gonadotropin-supported ovarian androgen biosynthesis: mechanism(s) and site(s) of action. Endocrinology 1990; 126: 3089–95.Google Scholar
38Koos, RD, Olson, CE. Expression of basic fibroblast growth factor in the rat ovary: detection of mRNA using reverse transcription- polymerase chain reaction amplification. Mol Endocrinol 1989; 3: 2041–48.Google Scholar
39Koos, RD, Seidel, RH. Detection of acidic fibroblast growth factor mRNA in the rat ovary using reverse transcription-polymerase chain reaction amplification. Biochem Biophys Res Commun 1989; 165: 82–8.CrossRefGoogle ScholarPubMed
40Lightman, A, Palumbo, A, DeCherney, AH, Naftolin, F. The ovarian renin angiotensin system. Semin Reprod Endocrinol 1989; 7: 79–87.Google Scholar
41Ojeda, SR, Lara, H, Ahmed, CE. Potential relevance of vasoactive intestinal peptide to ovarian physiology. Semin Reprod Endocrinol 1989; 7: 52–60.CrossRefGoogle Scholar
42Lara, HE, Hill, DF, Katz, KH, Ojeda, SR. The gene encoding nerve growth factor is expressed in the immature rat ovary: effect of denervation and hormonal treatment. Endocrinology 1990; 126: 357–63.CrossRefGoogle ScholarPubMed
43Iwai, M, Hasegaua, M, Tail, S et al. Endothelins inhibit luteinization of cultured porcine granulosa cells. Endocrinology 1991; 129: 1909–14.CrossRefGoogle ScholarPubMed
44Bird, TA, Saklatvala, J. Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin-1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654. J Biol Chem 1990; 265: 234–40.Google Scholar
45Brown, AB, Carpenter, G. Acute regulation of the epidermal growth factor receptor in response to nerve growth factor. J Neurochem 1991; 57: 1740–49.Google Scholar