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Perspective de la plate-forme NEMOSIS dans lecadre d’une réduction de doses en imagerie

Published online by Cambridge University Press:  09 November 2012

R. Laurent ,
R. Gschwind ,
M. Salomon ,
J. Henriet  and
L. Makovicka
R. Laurent
Affiliation:
IRMA/LCPR-AC/Chrono-Environnement, UMR 6249 CNRS, Université de Franche-Comté, BP 71427, 25211 Montbéliard Cedex, France
R. Gschwind
Affiliation:
IRMA/LCPR-AC/Chrono-Environnement, UMR 6249 CNRS, Université de Franche-Comté, BP 71427, 25211 Montbéliard Cedex, France
M. Salomon
Affiliation:
AND/DISC/FEMTO-ST, UMR 6174 CNRS, Université de Franche-Comté, BP 527, 90016 Belfort Cedex, France
J. Henriet
Affiliation:
IRMA/LCPR-AC/Chrono-Environnement, UMR 6249 CNRS, Université de Franche-Comté, BP 71427, 25211 Montbéliard Cedex, France
L. Makovicka
Affiliation:
IRMA/LCPR-AC/Chrono-Environnement, UMR 6249 CNRS, Université de Franche-Comté, BP 71427, 25211 Montbéliard Cedex, France
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Abstract

L’acquisition du mouvement est de plus en plus souvent effectuée pour améliorer la balistique des traitements en radiothérapie externe. Cependant, elle est source d’une exposition supplémentaire pour le patient. Le développement de la plate-forme de simulation numérique NEMOSIS (NEural NEtwork MOtion SImulation System) ouvre la voie à l’optimisation de la dose en imagerie. Elle permet de générer un mouvement pulmonaire localisé et personnalisé à partir du modèle 3D du patient. Pour 3 patients test, 5 à 6 points anatomiques ont été simulés puis comparés aux tracés du radiothérapeute. Dans le cas le plus défavorable, les résultats ont montré une précision moyennée sur l’ensemble des points d’un patient et sur toutes les phases d’environ 3 mm avec une incertitude élargie de tracé égale à 1,5 mm (intervalle de confiance de 95 %) et une incertitude maximale de phase atteignant 6,53 mm. Une autre étude comparant les GTV ( Gross Tumor Volume) d’un radiothérapeute et ceux calculés par NEMOSIS a été également menée. Un indice de Dice stipulant une correspondance minimale de 0,80 a été calculé entre les deux types de volumes. Ces résultats font de NEMOSIS un outil très prometteur en tant qu’alternative aux imageries irradiantes.

Keywords

lung motionnumerical simulationdose optimizationimaging
Type
Research Article
Information
Radioprotection , Volume 47 , Issue 4 , October 2012 , pp. 599 - 617
Copyright
© EDP Sciences, 2012

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