Hostname: page-component-8448b6f56d-c47g7 Total loading time: 0 Render date: 2024-04-24T19:52:10.055Z Has data issue: false hasContentIssue false
  • English
  • Français

Potential Influence of Diet on Bomb-Pulse Dating of Human Plaque Samples

Published online by Cambridge University Press:  09 February 2016

Elisavet Andersson Georgiadou ,
Isabel Gonçalves ,
Cintia Bertacchi Uvo ,
Jan Nilsson ,
Göran Skog ,
Sören Mattsson ,
Luis M Pedro ,
José Fernandes e Fernandes  and
Kristina Eriksson Stenström
Elisavet Andersson Georgiadou*
Affiliation:
Lund University, Department of Physics, Division of Nuclear Physics, Box 118, SE-221 00 Lund, Sweden
Isabel Gonçalves
Affiliation:
Department of Cardiology, Skåne University Hospital, Malmö, Sweden Cardiovascular Research Group, Department of Clinical Sciences, Malmö, Sweden
Cintia Bertacchi Uvo
Affiliation:
Lund University, Water Resources Engineering, Box 118, SE-221 00 Lund, Sweden
Jan Nilsson
Affiliation:
Cardiovascular Research Group, Department of Clinical Sciences, Malmö, Sweden
Göran Skog
Affiliation:
Lund University, Radiocarbon Dating Laboratory, Box 118, SE-221 00 Lund, Sweden
Sören Mattsson
Affiliation:
Lund University, Department of Clinical Sciences Malmö, Medical Radiation Physics, Skåne University Hospital, SE-205 02 Malmö, Sweden
Luis M Pedro
Affiliation:
Cardiovascular Institute of Lisbon, Lisbon, Portugal
José Fernandes e Fernandes
Affiliation:
Cardiovascular Institute of Lisbon, Lisbon, Portugal
Kristina Eriksson Stenström
Affiliation:
Lund University, Department of Physics, Division of Nuclear Physics, Box 118, SE-221 00 Lund, Sweden
*
2Corresponding author. Email: elisavet.georgiadou@nuclear.lu.se.
Get access Rights & Permissions [Opens in a new window]

Abstract

The radiocarbon concentration of different atherosclerotic plaque fragments obtained from 20 patients in Portugal, operated in 2000–2001, has been measured in order to define the year of plaque formation. A difference of 1.8–15 yr was observed, with the mean and median both 9 yr, between the bomb-pulse date estimated with the CALIBomb software and the operation date. Stable isotope (δ13C and δ15N) analysis was also performed and provides insight to the diet of the subjects. The wide range of measured stable isotope values could indicate that the subjects' diet varied, including an abundance of marine foodstuffs. It could also mean a different isotope fractionation process for the different plaque fragments (cap, core, interface to media) and a possible difference in tissues in which the various fragments are formed. Analysis of δ13C and δ15N values of each patient separately revealed subjects considered more influenced by marine foodstuffs consumption.

Type
Articles
Information
Radiocarbon , Volume 55 , Issue 2: Proceedings of the 21st International Radiocarbon Conference (Part 1 of 2) , 2013 , pp. 874 - 884
Copyright
Copyright © 2013 by the Arizona Board of Regents on behalf of the University of Arizona 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Broecker, WS, Schulert, A, Olson, EA. 1959. Bomb carbon-14 in human beings. Science 130(3371):331–2.CrossRefGoogle ScholarPubMed
Carvalho, FP. 1995. 210Po and 210Pb intake by the Portuguese population: the contribution of seafood in the dietary intake of 210Po and 210Pb. Health Physics 69(4):469–80.CrossRefGoogle ScholarPubMed
DeNiro, MJ, Epstein, S. 1981. Influence of diet on the distribution of nitrogen isotopes in animals. Geochimica et Cosmochimica Acta 45(3):341–51.CrossRefGoogle Scholar
Food and Agriculture Organization (FAO) of the United Nations. 2012. Food Balance Sheets: Portugal, Sweden, 2000–01, Food Supply. URL: http://faostat.fao.org/site/368/DesktopDefault.aspx. Accessed April 2012.Google Scholar
Gearing, JN. 1991. The study of diet and trophic relationships through natural abundance 13C. In: Coleman, DC, Fry, B, editors. Carbon Isotope Techniques. London: Academic Press. p 201–17.Google Scholar
Genberg, J, Stenström, K, Elfman, M, Olsson, M. 2010. Development of graphitization of μg-sized samples at Lund University. Radiocarbon 52(3):1270–6.Google Scholar
Georgiadou, E, Stenström, K. 2010. Bomb-pulse dating of human material: modeling the influence of diet. Radiocarbon 52(2):800–7.Google Scholar
Georgiadou, E, Eriksson Stenström, K, Bertacchi Uvo, C, Nilsson, P, Skog, G, Mattsson, S. 2013. Bomb-pulse 14C analysis combined with 13C and 15N measurements in blood serum from residents of Malmö, Sweden. Radiation and Environmental Biophysics, doi: 10.1007/S00411-013-0458-9.Google Scholar
Gonçalves, I, Stenström, K, Skog, G, Mattsson, S, Nitulescu, M, Nilsson, J. 2010. Dating components of human atherosclerotic plaques. Circulation Research 106(6):1174–7.CrossRefGoogle ScholarPubMed
Harkness, DD, Walton, A. 1969. Carbon-14 in the biosphere and humans. Nature 223(5212):1216–8.Google Scholar
Hua, Q, Barbetti, M. 2004. Review of tropospheric bomb 14C data for carbon cycle modeling and age calibration purposes. Radiocarbon 46(3):1273–98.Google Scholar
Libby, WF, Berger, R, Mead, JF, Alexander, GV, Ross, JF. 1964. Replacement rates for human tissue from atmospheric radiocarbon. Science 146(3648):1170–2.Google Scholar
Lynnerup, N, Kjeldsen, H, Heegaard, S, Jacobseb, C, Heinemeier, J. 2008. Radiocarbon dating of the human eye lens crystallines reveal proteins without carbon turnover throughout life. PLOS One 3(1):e1529, doi: 10.1371/journal.pone.0001529.Google Scholar
Marques-Vidal, P, Ravasco, P, Dias, CM, Camilo, ME. 2006. Trends of food intake in Portugal, 1987–1999: results from the National Health Surveys. European Journal of Clinical Nutrition 60(12):1414–22.CrossRefGoogle ScholarPubMed
Meier-Augenstein, W. 1999. Applied gas chromatography coupled to isotope ratio mass spectrometry. Journal of Chromatography A 842(1–2):321–71.Google Scholar
Minagawa, M. 1992. Reconstruction of human diet δ13C and δ15N in contemporary Japanese hair: a stochastic method for estimating multi-source contribution by double isotopic tracers. Applied Geochemistry 7(2):145–58.Google Scholar
Nash, SH, Bersamin, A, Kristal, AR, Hopkins, SE, Church, RS, Pasker, RL, Luick, BR, Mohatt, GV, Boyer, BB, O'Brien, MO. 2012. Stable nitrogen and carbon isotope ratios indicate traditional and market food intake in an indigenous circumpolar population. The Journal of Nutrition, Nutritional Epidemiology 142(1):84–90.Google Scholar
Nydal, R, Lövseth, K, Syrstad, O. 1971. Bomb 14C in the human population. Nature 232(5310):418–21.Google Scholar
O'Connell, TC. 1996. The isotopic relationship between diet and body proteins: implications for the study of diet in archaeology , xford: University of Oxford.Google Scholar
Reimer, PJ, Brown, TA, Reimer, RW. 2004. Discussion: reporting and calibration of post-bomb 14C data. Radiocarbon 46(3):1299–304.Google Scholar
Schoeller, DA. 1999. Isotope fractionation: Why aren't we what we eat? Journal of Archaeological Science 26(6):667–73.Google Scholar
Schoeller, DA, Minagawa, M, Slater, R, Kaplan, IR. 1986. Stable isotopes of carbon, nitrogen and hydrogen in the contemporary North American human food web. Ecology of Food and Nutrition 18(3):159–70.CrossRefGoogle Scholar
Skog, G. 2007. The single stage AMS machine at Lund University: status report. Nuclear Instruments and Methods in Physics Research B 259(1):1–6.Google Scholar
Skog, G, Rundgren, M, Sköld, P. 2010. Status of the Single Stage AMS machine at Lund University after 4 years of operation. Nuclear Instruments and Methods in Physics Research B 268(7–8):895–97.Google Scholar
Stenström, K, Skog, G, Nilsson, CM, Hellborg, R, Svegborn, SL, Georgiadou, E, Mattsson, S. 2010. Local variations in 14C – How is bomb-pulse dating of human tissues and cells affected? Nuclear Instruments and Methods in Physics Research B 268(7–8):1299–302.Google Scholar
Tieszen, LL, Boutton, TW, Tesdahl, KG, Slade, NA. 1983. Fractionation and turnover of stable carbon isotopes in animal tissues: implications for δ13C analysis of diet. Oecologia 57:32–37.Google Scholar
Ubelaker, DH, Buchholz, BA. 2005. Complexities in the use of bomb-curve radiocarbon to determine time since death of human skeletal remains. Forensic Science Communications, UCRL-JRNL-212160.Google Scholar
Vanderklift, MA, Ponsard, S. 2003. Sources of variation in consumer-diet δ15N enrichment: a meta-analysis. Oecologia 136(2):169–82.Google Scholar
Wilks, DS. 2006. Statistical Methods in the Atmospheric Sciences. 2nd edition. International Geophysics Series. New York: Academic Press.Google Scholar