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Chemical Kinetics and Fluorescence Correlation Spectroscopy†

Published online by Cambridge University Press:  17 March 2009

D. Magde
D. Magde
Affiliation:
Department of Chemistry, University of California, San Diego, La Jolla, Calfornia 92093, U.S.A.
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Extract

The dynamics of macromolecules, the subject of this symposium, are most directly studied by simply looking through a microscope and observing the molecular motion. With a microscope, we can resolve the size and shape of large particles, as well as monitor dynamic motion. For smaller particles, particularly single macromolecules, we cannot resolve the size or shape; but it is still possible to observe the motion, if we can make the particles appear as bright points of light sprinkled dilutely over a dark background. Siedentopf & Zsigmondy (1903) demonstrated this fact with a device which came to be called the ultramicroscope.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 9 , Issue 1 , February 1976 , pp. 35 - 47
Copyright
Copyright © Cambridge University Press 1976

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References

REFERENCES

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