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Calculation of unstirred layer thickness in membrane transport experiments: a survey

Published online by Cambridge University Press:  17 March 2009

T. J. Pedley
T. J. Pedley
Affiliation:
Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Silver Street, Cambridge CB3 9EW
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Extract

It has long been recognized that measurements of the permeability characteristics of membranes (and of epithelia) may be strongly influenced by the presence of unstirred, or diffusion, layers adjacent to the membranes: see Dainty (1963) for the first systematic discussion of the subject in a biological context and Barry & Diamond (1983) for an important recent review. Consider a homogeneous, plane, uncharged membrane separating two solutions of the same solute at different bulk concentrations Cb+ and Cb- (Fig. 1), but at the same hydrostatic pressure and electrostatic potential (note that in this paper subscripts + and − refer to the two sides of the membrane, not to cation and anion parameters; electroneutrality is assumed throughout).

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 16 , Issue 2 , May 1983 , pp. 115 - 150
Copyright
Copyright © Cambridge University Press 1983

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References

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