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Use of deuterium labelling in NMR studies of antibody combining site structure

Published online by Cambridge University Press:  17 March 2009

Jacob Anglister
Jacob Anglister
Affiliation:
Department of Polymer Research, The Weizmann Institute of Science, Rehovot 76100, Israel
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Extract

Antibody molecules secreted by B-lymphocytes play a central role in the immune defense systems of higher organisms. The major function of the antibody molecule is to bind specifically to foreign molecules (antigens) and to effect their inactivation and/or removal. Antibody molecules exist in millions of different forms, each with a unique amino acid sequence and combining site structure. Collectively called immunoglobulins (abbreviated as Ig), they form one of the major classes of proteins present in the blood, constituting 20% of the total plasma protein by weight.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 23 , Issue 2 , May 1990 , pp. 175 - 203
Copyright
Copyright © Cambridge University Press 1990

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