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Multi-stage proofreading in DNA replication

Published online by Cambridge University Press:  17 March 2009

Robert A. Beckman  and
Lawrence A. Loeb
Robert A. Beckman
Affiliation:
Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111
Lawrence A. Loeb
Affiliation:
Joseph Gottstein Memorial Cancer Research Laboratory, Department of Pathology SM-30, University of Washington, Seattle, WA 98195
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Extract

The mechanisms by which DNA polymerases achieve their remarkable fidelity, including base selection and proofreading, are briefly reviewed. Nine proofreading models from the current literature are evaluated in the light of steady-state and transient kinetic studies of E. coli DNA polymerase I, the beststudied DNA polymerase.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 26 , Issue 3 , August 1993 , pp. 225 - 331
Copyright
Copyright © Cambridge University Press 1993

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