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Controlling the movement of molecules

Published online by Cambridge University Press:  14 May 2019

Robert Langer
Affiliation:
Massachusetts Institute of Technology, Cambridge, MA, USA
Corresponding
E-mail address:

Abstract

The ability to control the movement of molecules is both fascinating scientifically as well as being critically important to the well-being of our planet and its people. In particular, the sustained release of molecules over prolonged periods at controlled rates has had and will continue to have enormous implications for the delivery of substances in medicine, agriculture, the environment, nutrition, aquaculture, household consumer products, and numerous other areas. This field is advancing at a rapidly accelerating pace. In this article, I largely discuss our own work, starting 45 years ago, in enabling the controlled release of macromolecules from biocompatible polymers. I also discuss the synthesis of novel materials to affect molecular movement and I then examine external approaches for controlling the movement of molecules through materials, using forces such as electric, acoustic, and magnetic fields. I further discuss approaches for controlling molecular movement through physiologic barriers, such as the skin, lung, and intestine. Finally, I outline several future areas of this field, including how it can affect the developing world, the ability to control the movement of molecules into mammalian cells, and the design of intelligent approaches to control molecular delivery.

Type
Review
Copyright
Copyright © Cambridge University Press 2019 

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References

Abramson, A, Caffarel-Salvador, E, Khang, M, Dellal, D, Silverstein, D, Gao, Y, Frederiksen, M, Vegge, A, Hubálek, F, Water, J, Friderichsen, A, Fels, J, Kirk, R, Cleveland, C, Collins, J, Tamang, S, Hayward, A, Landh, T, Buckley, S, Roxhed, N, Rahbek, U, Langer, R and Traverso, G (2019) An ingestible self-orienting system for oral delivery of macromolecules. Science 363, 611615.CrossRefGoogle ScholarPubMed
Akinc, A, Zumbuehl, A, Goldberg, M, Leshchiner, E, Busini, V, Hossain, N, Bacallado, S, Nguyen, D, Fuller, J, Alvarez, R, Borodovsky, A, Borland, T, Constein, R, de Fougerolles, A, Dorkin, J, Jayaprakash, K, Jayaraman, M, John, M, Kotelianski, V, Manoharan, M, Nechev, L, Qin, J, Racie, T, Raitcheva, D, Rajeev, K, Sah, D, Soutschek, J, Toudjarska, I, Vornlocher, HP, Zimmermann, T, Langer, R and Anderson, D (2008) A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nature Biotechnology 26, 561569, PMID: 18438401, PMCID: N/A – NIH not acknowledged on this paper.CrossRefGoogle ScholarPubMed
Anselmo, A, Xu, X, Buerkli, S, Zeng, Y, Tang, W, McHugh, K, Behrens, A, Rosenberg, E, Duan, A, Sugarman, J, Zhuang, J, Collins, J, Lu, X, Graf, T, Tzeng, S, Rose, S, Nguyen, T, Le, X, Guerra, A, Freed, L, Weinstock, S, Sears, C, Nikolic, B, Wood, L, Oxley, J, Moretti, D, Zimmermann, M, Langer, R and Jaklenec, A (2019) Development of a heat-stable microparticle platform for oral micronutrient delivery: from conception to human trials. Submitted.Google Scholar
Balazs, A, Calef, D, Deutch, J, Siegel, R and Langer, R (1985) The role of polymer matrix structure & interparticle interactions in diffusion limited drug release. Biophysical Journal 47, 97104.CrossRefGoogle ScholarPubMed
Ball, P (1999) Made to Measure: New Materials for the 21st Century. Princeton, NJ: Princeton University Press, p. 241.Google Scholar
Batycky, R, Hanes, J, Langer, R and Edwards, D (1997) Theoretical model of erosion and macromolecular drug release from biodegrading microspheres. Journal of Pharmaceutical Science 86, 14641477.CrossRefGoogle ScholarPubMed
Bawa, R, Siegel, R, Marasca, B, Karel, M and Langer, R (1985) An explanation for the sustained release of macromolecules from polymers. Journal of Controlled Release l, 259267.CrossRefGoogle Scholar
Bellinger, A, Jafari, M, Grant, T, Zhang, S, Slater, H, Wenger, E, Mo, S, Lee, Y, Mazdiyasni, H, Kogan, L, Barman, R, Cleveland, C, Booth, L, Bensel, T, Minahan, D, Hurowitz, H, Tai, T, Daily, J, Nikolic, B, Wood, L, Eckhoff, P, Langer, R and Traverso, G (2016) Oral, ultra-long-lasting drug delivery: application toward malaria elimination goals. Science Translational Medicine 4, 365ra157, PMCID: PMC5264553.CrossRefGoogle Scholar
Brem, H and Langer, R (1996) Polymer-based drug delivery to the brain. Scientific American: Science and Medicine 3, 5261.Google Scholar
Carmeliet, P (2005) Angiogenesis in life, disease, and medicine. Nature 438, 932936.CrossRefGoogle Scholar
Chowdhary, S, Ryken, T and Newton, H (2015) Survival outcomes and safety of carmustine wafers in the treatment of high-grade gliomas: a meta-analysis. Journal of Neurooncology 122, 367382. PMID: 25630625.CrossRefGoogle ScholarPubMed
Cline, H, Debski, E and Constantine-Paton, M (1987) N-methyl-D-aspartate receptor antagonist desegregates eye specific stripes. PNAS 84, 43424345.CrossRefGoogle ScholarPubMed
Cohen, J, Siegel, R and Langer, R (1984) Sintering technique for preparation of polymer matrices for the sustained release of macromolecules. Journal of Pharmaceutical Sciences 73, 10341037.CrossRefGoogle ScholarPubMed
Cohen, S, Yoshioka, T, Lucarelli, M, Hwang, L and Langer, R (1991) Controlled delivery systems for proteins based on poly(lactic/glycolic acid) Microspheres. Pharmaceutical Research 8, 713720.CrossRefGoogle ScholarPubMed
Connolly, D, Heuvelman, D, Nelson, R, Olander, J, Eppley, B, Delfino, J, Siegel, N, Leimgruber, R and Feder, J (1989) Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. Journal of Clinical Investigation 84, 14701478.CrossRefGoogle ScholarPubMed
Cooke, R (2001) Dr. Folkmans War: Angiogenesis and the Struggle to Defeat Cancer. New York, NY: Random House, p. 179.Google Scholar
Cramer, D (1998) Applied vascular biology: can angiogenesis inhibitors help control malignant growth. Annals of Internal Medicine 129, 841843.CrossRefGoogle ScholarPubMed
Dahlman, J, Barnes, C, Khan, O, Thiriot, A, Jhunjunwala, S, Shaw, T, Xing, Y, Sage, H, Sahay, G, Speciner, L, Bader, A, Bogorad, R, Yin, H, Racie, T, Dong, Y, Jiang, S, Seedorf, D, Dave, A, Sandu, K, Webber, M, Novobrantseva, T, Ruda, V, Lytton-Jean, A, Levins, C, Kalish, B, Mudge, D, Perez, M, Abezgauz, L, Dutta, P, Smith, L, Charisse, K, Kieran, M, Fitzgerald, K, Nahrendorf, M, Danino, D, Tuder, R, von Andrian, U, Akinc, A, Schroeder, A, Panigrahy, D, Kotelianski, V, Langer, R and Anderson, D (2014) In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nature Nanotechnology 9, 648655, PMCID: PMC4207430.CrossRefGoogle ScholarPubMed
DiTommaso, T, Cole, J, Cassereau, L, Buggé, J, Hanson, J, Bridgen, D, Stokes, B, Loughhead, S, Beutel, B, Gilbert, J, Nussbaum, K, Sorrentino, A, Toggweiler, J, Schmidt, T, Gyuelveszi, G, Bernstein, H and Sharei, A (2018) Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo. PNAS 115, E10907E10914.CrossRefGoogle ScholarPubMed
Domb, A and Langer, R (1987) Polyanhydrides: I. preparation of high molecular weight polyanhydrides. Journal of Polymer Science 25, 33733386.Google Scholar
Domb, A, Cravalho, EG and Langer, R (1988 a) The synthesis of poly(hydroxamic) from poly(acrylamide). Journal of Polymer Science 26, 26232630.Google Scholar
Domb, A, Ron, E and Langer, R (1988 b) Polyanhydrides II. One step polymerization using phosgene or diphosgene as coupling agents. Macromolecules 21, 19251929.CrossRefGoogle Scholar
Domb, A, Gallardo, C and Langer, R (1989) Poly(anhydrides) 3. Poly(anhydrides) based on aliphaticaromatic diacids. Macromolecules 22, 32003204.CrossRefGoogle Scholar
Edelman, E, Kost, J, Bobeck, H and Langer, R (1985) Regulation of drug release from porous polymer matrices by oscillating magnetic fields. Journal of Biomedical Materials Research 19, 6783.Google Scholar
Edwards, D and Langer, R (1994) A linear theory of transdermal transport phenomena. Journal of Pharmaceutical Sciences 83, 13151334.CrossRefGoogle ScholarPubMed
Edwards, D, Hanes, J, Caponetti, G, Hrkach, J, Ben-Jebria, A, Eskew, M, Mintzes, J, Deaver, D, Lotan, N and Langer, R (1997) Large porous aerosols for pulmonary drug delivery. Science 276, 18681871.CrossRefGoogle ScholarPubMed
Farra, R, Sheppard, N, McCabe, L, Neer, R, Anderson, J, Santini, J, Cima, M and Langer, R (2012) First in-human testing of a wirelessly controlled drug delivery microchip. Science Translational Medicine 4, 122ra21.CrossRefGoogle ScholarPubMed
Fischel-Ghodsian, F, Brown, L, Mathiowitz, E, Brandenburg, D and Langer, R (1988) Enzymatically controlled drug delivery. Proceedings of the National Academy of Sciences 85, 24032406.CrossRefGoogle ScholarPubMed
Fukaya, M, Ueda, H, Sato, A, Kaeriyama, M, Ando, H, Zohar, Y, Urano, A and Yamauchi, K (1998) Acceleration of gonadal maturation in anadromous maturing sockeye salmon by gonadotropin-releasing hormone analog implantation. Fisheries Science 64, 948951.CrossRefGoogle Scholar
Fung, LK, Shin, M, Tyler, B, Brem, H and Saltzman, WM (1996) Chemotherapeutic drugs released from polymers: distribution of 1,3-bis(2-chloroethyl)-1-nitrosourea in the rat brain. Pharmaceutical Research 13, 671682. PMID 8860421.CrossRefGoogle ScholarPubMed
Fung, LK, Ewend, MG, Sills, A, Sipos, EP, Thompson, R, Watts, M, Colvin, OM, Brem, H and Saltzman, WM (1998) Pharmacokinetics of interstitial delivery of carmustine, 4-hydroperoxycyclophosphamide, and paclitaxel from a biodegradable polymer implant in the monkey brain. Cancer Research 58, 672684, PMID 9485020.Google ScholarPubMed
Gospodarowicz, D, Bialecki, H and Thakral, T (1979) Angiogenic activity of the fibroblast and epidermal growth factor. Experimental Eye Research 28, 501514.CrossRefGoogle ScholarPubMed
Gref, R, Minamitake, Y, Peracchia, M, Trubetskoy, V, Torchillin, V and Langer, R (1994) Biodegradable long-circulating polymeric nanospheres. Science 263, 16001603.CrossRefGoogle ScholarPubMed
Haller, MF and Saltzman, WM (1998) Localized delivery of proteins in the brain: can transport be customized? Pharmaceutical Research 15, 377385. PMID 9563066.CrossRefGoogle ScholarPubMed
Holland, MCH, Hassin, S and Zohar, Y (2003) The effects of long-term testosterone, gonadotropin-releasing hormone agonist and pimozide treatments on testicular development and luteinizing hormone levels in juvenile and early maturing striped bass, Morone saxatilis. General and Comparative Endocrinology 129, 178187 (featured on the journal cover).CrossRefGoogle Scholar
Hsieh, D, Langer, R and Folkman, J (1981) Magnetic modulation of release of macromolecules from Polymers. Proceedings of the National Academy of Sciences 78, 18631867.CrossRefGoogle ScholarPubMed
Hsieh, D, Rhine, W and Langer, R (1983) Zero-order controlled release polymer matrices for micromolecules and macromolecules. Journal of Pharmaceutical Sciences 72, 1722.CrossRefGoogle Scholar
Hsu, T and Langer, R (1985) Polymers for the controlled release of macromolecules: effect of molecular weight of ethylene-vinyl acetate copolymer. Journal of Biomedical Materials Research 19, 445460.CrossRefGoogle ScholarPubMed
Johnson, M, Berk, D, Blankschtein, D, Golan, D, Jain, R and Langer, R (1996) Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems. Biophysics Journal 71, 26562668.CrossRefGoogle ScholarPubMed
Johnson, M, Blankschtein, D and Langer, R (1997) Evaluation of solute permeation through the stratum corneum: lateral bilayer diffusion as the primary transport mechanism. Journal of Pharmaceutical Science 86, 11621172.CrossRefGoogle ScholarPubMed
Kalb, R and Hockfield, S (1990) Induction of a neuronal proteoglycan by the NMDA receptor in the developing spinal cord. Science 250, 294296.CrossRefGoogle ScholarPubMed
Kirtane, A, Abouzid, O, Minahan, D, Bensel, T, Hill, AL, Selinger, C, Bershteyn, A, Craig, M, Mo, SS, Mazdiyasni, H, Cleveland, C, Rogner, J, Lee, Y, Booth, L, Javid, F, Wu, S, Grant, G, Bellinger, A, Nikolic, B, Hayward, A, Wood, L, Eckhoff, PA, Nowak, M, Langer, R and Traverso, G (2018) Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy. Nature Communications 9, Article 2.CrossRefGoogle ScholarPubMed
Kost, J, Leong, K and Langer, R (1989) Ultrasound-enhanced polymer degradation and release of incorporated substances. Proceedings of the National Academy of Sciences 86, 76637666.CrossRefGoogle ScholarPubMed
Kost, J, Mitragotri, S, Gabbay, R, Pishko, M and Langer, R (2000) Non-invasive blood glucose measurement using ultrasound. Nature Medicine 6, 347350.CrossRefGoogle Scholar
Lahann, J, Mitragotri, S, Tran, T, Kaido, H, Sundaran, J, Hoffer, S, Somorjai, GA and Langer, R (2003) Reversible switching of surfaces. Science 299, 371374.CrossRefGoogle Scholar
Langer, R and Folkman, J (1976) Polymers for the sustained release of proteins and other macromolecules. Nature 263, 797800.CrossRefGoogle ScholarPubMed
Langer, R and Folkman, J (1978) Sustained release of macromolecules from polymers. Polymeric Delivery Systems, Midland Macro. Monograph 5, 175196, R. Kostelnik, ed., Gordon and Breach, New York.Google Scholar
Langer, R, Brem, H, Falterman, K, Klein, M and Folkman, J (1976) Isolation of a cartilage factor that inhibits tumor neovascularization. Science 193, 7072.Google ScholarPubMed
Langer, R, Rhine, W, Hsieh, D and Folkman, J (1980) Control of release kinetics of macromolecules from polymers. Journal of Membrane Science 7, 333350.CrossRefGoogle Scholar
Lash, A (2014) Langer, Led Zeppelin, and Hookups: Three Days Behind the BIO Scenes. Exome.com. Available at https://xconomy.com/san-diego/2014/06/27/langer-led-zeppelin-and-hookups-three-days-behind-the-bio-scenes (Accessed 28 February 2019).Google Scholar
Laurencin, C, Domb, A, Morris, C, Brown, V, Chasin, M, McConnell, R, Lange, N and Langer, R (1990) Poly(anhydride) administration in high doses in vivo: studies of biocompatibility and toxicology. Journal of Biomedical Materials Research 24, 14631481.CrossRefGoogle ScholarPubMed
Lendlein, A and Langer, R (2002) Biodegradable, elastic shape memory polymers for potential biomedical applications. Science 296, 16731676.Google ScholarPubMed
Lendlein, A, Jiang, H, Junger, O and Langer, R (2005) Light-induced shape-memory polymers. Nature 434, 879882.Google ScholarPubMed
Leong, K, Brott, B and Langer, R (1985) Bioerodible polyanhydrides as drug-carrier matrices: I. characterization, degradation and release characteristics. Journal of Biomedical Materials Research 19, 941955.CrossRefGoogle ScholarPubMed
Leong, K, D'Amore, P, Marletta, M and Langer, R (1986) Bioerodible polyanhydrides as drug-carrier matrices II: biocompatibility and chemical reactivity. Journal of Biomedical Materials Research 20, 5164.CrossRefGoogle ScholarPubMed
Levy, D, Kost, J, Meshulam, Y and Langer, R (1989) Effect of ultrasound on transdermal drug delivery to rats and guinea pigs. Journal of Clinical Investigation 83, 20742078.CrossRefGoogle ScholarPubMed
Liang, J, Yu, J and Robertson, R (1995) Sustained inhibition of acetylcholinesterase activity does not disrupt early geniculocortical ingrowth to developing rat visual cortex. Developmental Brain Research 86, 354358.CrossRefGoogle Scholar
Linnehan, R (2018) ‘FDA approves Inveltys for treatment of inflammation, pain after ocular surgery,’ healio.com, 8/23/2018. Available at https://www.healio.com/ophthalmology/cataract-surgery/news/online/%7Bef827c6d-648b-4a9f-8a93-7fab69b73622%7D/fda-approves-inveltys-for-treatment-of-inflammation-pain-after-ocular-surgery (Accessed 19 February 2019).Google Scholar
Lynn, D and Langer, R (2000) Degradable poly(b-amino esters): synthesis, characterization, and self-assembly with plasmid DNA. Journal of the American Chemical Society 122, 1076110768.CrossRefGoogle Scholar
Marino, G, Panini, E, Longobardi, A, Mandich, A, Fionia, MG, Zohar, Y and Mylonas, CC (2003) Induction of ovulation in captive-reared dusky grouper, Epinephelus marginatus (Lowe, 1834), with a sustained release GnRHa implant. Aquaculture 326, 118.Google Scholar
Mathiowitz, E, Saltzman, M, Domb, A, Dor, P and Langer, R (1988) Polyanhydride microspheres as drug carriers. II: microencapsulation by solvent removal. Journal of Applied Polymer Science 35, 755774.CrossRefGoogle Scholar
Mathiowitz, E, Dor, P, Amato, C and Langer, R (1990) Polyanhydride microspheres as drug carriers III morphology and release characterization of microspheres made by solvent removal. Polymer 31, 547556.CrossRefGoogle Scholar
McAuslan, BR and Gole, GA (1980) Cellular and molecular mechanisms in angiogenesis. Transactions of the Ophthalmological Societies of the UK 100, 354358.Google ScholarPubMed
McHugh, K, Nguyen, T, Linehan, A, Yang, D, Behrens, A, Rose, S, Tochka, Z, Tzeng, S, Norman, J, Anselmo, A, Xu, X, Tomasic, S, Taylor, M, Lu, J, Guarecuco, R, Langer, R and Jaklenec, A (2017) Fabrication of fillable microparticles and other complex 3D microstructures. Science 357, 11381142.CrossRefGoogle ScholarPubMed
Mitragotri, S (2013) Engineering approaches to transdermal drug delivery: a tribute to contributions of Prof. Robert Langer. Skin Pharmacology of Physiology 26, 263276. https://doi.org/10.1159/000351947.CrossRefGoogle ScholarPubMed
Mitragotri, S, Blankschtein, D and Langer, R (1995) Ultrasound-mediated transdermal protein delivery. Science 269, 850853.CrossRefGoogle ScholarPubMed
Mylonas, CC and Zohar, Y (1998) New techniques for the control of gamete maturation in marine fishes as tools in broodstock management. Cah. Opt. Med. 34, 193213.Google Scholar
Mylonas, CC, Richardson, BM, Minkinnen, SP and Zohar, Y (1995) Induced spawning of American shad (Alosa sapidissima) using sustained administration of gonadotropin-releasing hormone analog (GnRHa). Journal of the World Aquaculture Society 26, 3950.CrossRefGoogle Scholar
Mylonas, CC, Gissis, A, Magnus, Y and Zohar, Y (1997) Hormonal changes in male white bass (Morone chrysops) and evaluation of milt quality after treatment with a sustained-release GnRHa delivery system. Aquaculture 153, 301313.CrossRefGoogle Scholar
Mylonas, CC, Bridges, CR, Gordin, H, Belmonte Ríos, A, García, A, De la Gándara, F, Fauvel, C, Suquet, M, Medina, A, Papadaki, M, Heinisch, G, De Metrio, G, Corriero, A, Vassallo-Agius, R, Guzmán, JM, Mañanos, E and Zohar, Y (2007) Preparation and administration of gonadotropin-releasing hormone agonist (GnRHa) implants for the artificial control of reproductive maturation in captive-reared Atlantic bluefin tuna (Thunnus thynnus). Reviews in Fisheries Science 15, 183210.CrossRefGoogle Scholar
National Academy of Sciences (1999) ‘Polymers and People,’ Beyond Discovery. National Academy of Sciences. Nov. 1999. Available at http://www.nasonline.org/publications/beyond-discovery.Google Scholar
Park, C and Hollenberg, M (1993) Growth factor-induced retinal regeneration in vivo. International Review of Cytology 146, 49.CrossRefGoogle ScholarPubMed
Pearson, H (2009) Profile: being Bob Langer. Nature 458, 2224.CrossRefGoogle ScholarPubMed
Peppas, N and Langer, R (1994) New challenges in biomaterials. Science 263, 17151720.CrossRefGoogle ScholarPubMed
Pliskin, M, Ginsberg, S and Carp, N (1980) Induction of neovascularization by mitogen activated spleen cells and their supernatants. Transplantation 29, 225258.CrossRefGoogle ScholarPubMed
Polat, B, Deen, W, Langer, R and Blankschtein, D (2012) A physical mechanism to explain the delivery of chemical penetration enhancers into skin during transdermal sonophoresis: insight into the observed synergism. Journal of Controlled Release 158, 250260, PMCID: PMC3294085.CrossRefGoogle ScholarPubMed
Polverini, P, Cotran, R, Gimbrone, M and Unanue, E (1977) Activated macro-phages induces vascular proliferation. Nature 269, 804805.Google Scholar
Prausnitz, M, Langer, R and Weaver, J (1993 a) Electroporation of mammalian skin: a new mechanism to enhance transdermal drug delivery. Proceedings of the National Academy of Sciences 90, 1050410508.CrossRefGoogle Scholar
Prausnitz, M, Seddick, D, Kon, A, Bose, V, Frankenburg, S, Klaus, S, Langer, R and Weaver, J (1993 b) Methods for in vivo tissue electroporation using surface electrodes. Drug Delivery 1, 125131.CrossRefGoogle Scholar
Prausnitz, M, Pliquett, U, Langer, R and Weaver, J (1994) Rapid temporal control of transdermal drug delivery by electroporation. Pharmaceutical Research 11, 18341837.CrossRefGoogle ScholarPubMed
Prausnitz, M, Corbett, J, Gimm, J, Golan, D, Langer, R and Weaver, J (1995) Millisecond measurement of transport during and after an electroporation pulse. Biophysical Journal 68, 18641870.CrossRefGoogle ScholarPubMed
Prausnitz, M, Gimm, J, Weaver, J, Guy, R, Langer, R and Cullander, C (1996 a) Imaging regions of transport across human stratum corneum during high-voltage and low-voltage exposures. Journal of Pharmaceutical Sciences 85, 13631370.CrossRefGoogle ScholarPubMed
Prausnitz, M, Lee, C, Liu, C, Pang, J, Singh, T, Weaver, J and Langer, R (1996 b) Transdermal transport efficiency during skin electroporation and iontophoresis. Journal of Controlled Release 38, 205217.CrossRefGoogle Scholar
Preis, I and Langer, R (1979) A single-step immunization by sustained antigen release. Journal of Immunology. Methamphetamine 28, 193197.CrossRefGoogle ScholarPubMed
Queen Elizabeth Prize for Engineering Foundation (2015) ‘Robert S. Langer, Winner Infographic,’ Queen Elizabeth Prize for Engineering Foundation. Feb. 2015, Available at http://qeprize.org/wp-content/uploads/2015/02/Winner_infographic.pdf.Google Scholar
Reh, T and Constantine-Paton, M (1985) Eye-specific segregation requires neural activity in three-eyed Rana pipiens. Journal of Neuroscience 5, 11321143.CrossRefGoogle ScholarPubMed
Rhine, W, Hsieh, D and Langer, R (1980) Polymers for sustained macromolecule release: procedures to fabricate reproducible delivery systems and control release kinetics. Journal of Pharmaceutical Sciences 69, 265270.CrossRefGoogle ScholarPubMed
Rosen, H, Chang, J, Wnek, G, Linhardt, R and Langer, R (1983) Bioerodible polyanhydrides for controlled drug delivery. Biomaterials 4, 131133.CrossRefGoogle ScholarPubMed
Saltzman, W and Langer, R (1989) Transport rates of proteins in porous materials with known microgeometry. Biophysical Journal 55, 163171.CrossRefGoogle ScholarPubMed
Santini, J, Cima, M and Langer, R (1999) A controlled-release microchip. Nature 397, 335338.CrossRefGoogle ScholarPubMed
Schor, AM, Schor, SL and Kumar, S (1979) Importance of a collagen substratum for stimulation of capillary endothelial cell proliferation by tumor angiogenesis factor. International Journal of Cancer 24, 225234.CrossRefGoogle Scholar
Science History Institute (2015) ‘Scientists You Must Know: Robert Langer,’ Science History Institute (formerly Chemical Heritage Foundation). 2015. Available at https://vimeo.com/104137880.Google Scholar
Sefton, M, Brown, L and Langer, R (1984) Ethylene-vinyl acetate microspheres for controlled release of macromolecules. Journal of Pharmaceutical Sciences 73, 18591861.CrossRefGoogle ScholarPubMed
Sharei, A, Zoldan, J, Adamo, A, Sim, W-Y, Cho, N, Jackson, E, Mao, S, Schneider, S, Han, M-J, Lytton-Jean, A, Basto, PA, Jhunjhunwala, S, Lee, J, Heller, DA, Kang, JW, Hartoularos, GC, Kim, K-S, Anderson, DG, Langer, R and Jensen, KF (2013) A vector-free microfluidic platform for intracellular delivery. Proceedings of the National Academy of Sciences 110, 20822087, PMCID: PMC3568376.CrossRefGoogle ScholarPubMed
Shing, Y, Folkman, J, Sullivan, R, Butterfield, C, Murray, J and Klags-brun, M (1984) Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science 23, 12961299.CrossRefGoogle Scholar
Silberstein, G and Daniel, C (1982) Elvax 40P implants: sustained, local release of bioactive molecules influencing mammary ductal development. Developmental Biology 93, 272278.CrossRefGoogle ScholarPubMed
Simone, D, Prusky, G, O'Leary, D and Constantine-Paton, M (1992) N-methyl-D-aspartate receptor antagonists disrupt the formation of mammalian neural map. PNAS 89, 1059310597.CrossRefGoogle Scholar
Sorbera, LA, Mylonas, CC, Zanuy, S, Carrillo, M and Zohar, Y (1996) Sustained administration of GnRHa increases sperm volume without altering sperm counts in the seabass (Dicentrarchus labrax). Journal of Experimental Zoology 276, 361368.3.0.CO;2-M>CrossRefGoogle Scholar
Stannett, V, Koros, W, Paul, D, Lonsdale, H and Baker, R (1979) Recent advances in membrane and science technology. Advances in Polymer Science 32, 69121.CrossRefGoogle Scholar
Tamada, J and Langer, R (1993) Erosion kinetics of hydrolytically degradable polymers. Proceedings of the National Academy of Sciences 90, 552556.CrossRefGoogle ScholarPubMed
Tang, H, Mitragotri, S, Blankschtein, D and Langer, R (2001) Theoretical description of transdermal transport of hydrophilic permeants: application to low-frequency sonophoresis. Journal of Pharmaceutical Sciences 90, 545568.3.0.CO;2-H>CrossRefGoogle ScholarPubMed
Tang, H, Blankschtein, D and Langer, R (2002) Effects of low-frequency ultrasound on the transdermal permeation of mannitol: comparative studies with in vivo and in vitro skin. Journal of Pharmaceutical Sciences 91, 17761794.CrossRefGoogle ScholarPubMed
Taranger, GL, Vikingstad, E, Klenke, U, Mayer, I, Stefansson, SO, Norberg, B, Hansen, T, Zohar, Y and Andersson, E (2004) Effects of photoperiod, temperature and GnRHa treatment on the reproductive physiology of Atlantic salmon (Salmo salar L.) broodstock. Fish Physiology and Biochemistry 28, 403406.CrossRefGoogle Scholar
Valtonen, S, Timonen, U, Toivanen, P, Kalimo, H, Kivipelto, L, Heiskanen, O, Unsgaard, G and Kuurne, T (1997) Interstitial chemotherapy with carmustine-loaded polymers for high-grade gliomas: a randomized double-blind study. Neurosurgery 41, 4449.CrossRefGoogle ScholarPubMed
Viswanathan, M, Golin, CE, Jones, CD, Ashok, M, Blalock, SJ, Wines, RC, Coker-Schwimmer, EJ, Rosen, DL, Sista, P and Lohr, KN (2012) Interventions to improve adherence to self-administered medications for chronic diseases in the United States: a systematic review. Annals of Internal Medicine 157, 785795.CrossRefGoogle ScholarPubMed
Zelikin, A, Shastri, V, Lynn, D, Farhadi, J, Martin, I and Langer, R (2002) Erodible conducting polymers for potential biomedical applications. Angewandte Chemie 41, 141144.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
Zhang, S, Bellinger, A, Glettig, D, Barman, R, Lee, Y-A, Zhu, J, Cleveland, C, Montgomery, V, Gu, L, Nash, L, Maitland, D, Langer, R and Traverso, G (2015) A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices. Nature Materials 10, 10651071, PMID: 26213897; PMCID: 4772966.CrossRefGoogle Scholar
Zohar, Y and Mylonas, CC (2001) Endocrine manipulations of spawning in farmed fish: from hormones to genes. Aquaculture 197, 99136.CrossRefGoogle Scholar

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Controlling the movement of molecules
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