Skip to main content Accessibility help
×
Home

An electrophysiological index of stimulus unfamiliarity

  • KIRK R. DAFFNER (a1), M. MARSEL MESULAM (a2), LEONARD F.M. SCINTO (a1), VIVIAN CALVO (a1), ROBERT FAUST (a1) and PHILLIP J. HOLCOMB (a3)...

Abstract

This study investigated the functional significance of the N2 response to novel stimuli. In one condition, background, target, and deviant stimuli were simple geometric figures. In a second condition, all stimulus types were unfamiliar/unusual figures. In a third condition, background and target stimuli were unusual figures and deviant stimuli were simple shapes. Unusual figures, whether they were deviant, target, or background stimuli, evoked larger N2 responses than their simple, familiar counterparts. N2 elicited by an unusual background stimulus was larger than that evoked by simple, deviant stimuli, a pattern opposite that exhibited by the subsequent P3. Deviance from immediate context had limited influence over N2 amplitude. The results suggest that novelty N2 and novelty P3 reflect the processing of different aspects of “novel” visual stimuli. The novelty P3 is particularly sensitive to deviation from immediate context. In contrast, the novelty N2 is sensitive to deviation from long-term context that renders a stimulus unfamiliar and difficult to encode.

Copyright

Corresponding author

Address reprint requests to: Kirk R. Daffner, Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA. E-mail: kdaffner@partners.org.

Keywords

An electrophysiological index of stimulus unfamiliarity

  • KIRK R. DAFFNER (a1), M. MARSEL MESULAM (a2), LEONARD F.M. SCINTO (a1), VIVIAN CALVO (a1), ROBERT FAUST (a1) and PHILLIP J. HOLCOMB (a3)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed