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Temporal reproduction and its neuroanatomical correlates in adults with attention deficit hyperactivity disorder and their unaffected first-degree relatives

  • V. A. Pironti (a1) (a2) (a3), M.-C. Lai (a4) (a5), S. Morein-Zamir (a1) (a2), U. Müller (a1) (a3), E. T. Bullmore (a1) (a2) and B. J. Sahakian (a1) (a2)...

Abstract

Background

Little is known about time perception, its putative role as cognitive endophenotype, and its neuroanatomical underpinnings in adults with attention deficit hyperactivity disorder (ADHD).

Method

Twenty adults with ADHD, 20 unaffected first-degree relatives and 20 typically developing controls matched for age and gender undertook structural magnetic resonance imaging scans. Voxel-based morphometry with DARTEL was performed to obtain regional grey-matter volumes. Temporal processing was investigated as a putative cognitive endophenotype using a temporal reproduction paradigm. General linear modelling was employed to examine the relationship between temporal reproduction performances and grey-matter volumes.

Results

ADHD participants were impaired in temporal reproduction and unaffected first-degree relatives performed in between their ADHD probands and typically developing controls. Increased grey-matter volume in the cerebellum was associated with poorer temporal reproduction performance.

Conclusions

Adults with ADHD are impaired in time reproduction. Performances of the unaffected first-degree relatives are in between ADHD relatives and controls, suggesting that time reproduction might be a cognitive endophenotype for adult ADHD. The cerebellum is involved in time reproduction and might play a role in driving time performances.

Copyright

Corresponding author

*Address for correspondence: Dr V. A. Pironti, Department of Psychiatry, University of Cambridge, Herschel Smith Building for Brain and Mind Sciences, Cambridge Biomedical Campus, Cambridge, CB2 0SZ, UK. (Email: vp271@cam.ac.uk)

References

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Almasy, L, Blangero, J (2001). Endophenotypes as quantitative risk factors for psychiatric disease: rationale and study design. American Journal of Medical Genetics 105, 4244.
APA (2000). Diagnostic and Statistical Manual of Mental Disorders, 4th edn, Text Revision (DSM-IV-TR). American Psychiatric Association: Washington, DC.
Aron, AR, Poldrack, RA (2005). The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder. Biological Psychiatry 57, 12851292.
Ashburner, J (2007). A fast diffeomorphic image registration algorithm. Neuroimage 38, 95113.
Barkley, R (2006). Associated cognitive, developmental, and health problems. In Attention-Deficit Hyperactivity Disorder (ed. Barkley, R.), pp. 122183. The Guilford Press: New York.
Barkley, R (2011). Barkley Adult ADHD Rating Scale–IV (BAARS-IV). The Guilford Press: New York.
Barkley, RA, Edwards, G, Laneri, M, Fletcher, K, Metevia, L (2001 a). Executive functioning, temporal discounting, and sense of time in adolescents with attention deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD). Journal of Abnormal Child Psychology 29, 541556.
Barkley, RA, Koplowitz, S, Anderson, T, McMurray, MB (1997). Sense of time in children with ADHD: effects of duration, distraction, and stimulant medication. Journal of the International Neuropsychological Society 3, 359369.
Barkley, RA, Murphy, KR, Bush, T (2001 b). Time perception and reproduction in young adults with attention deficit hyperactivity disorder. Neuropsychology 15, 351360.
Bauermeister, JJ, Barkley, RA, Martinez, JV, Cumba, E, Ramirez, RR, Reina, G, Matos, M, Salas, CC (2005). Time estimation and performance on reproduction tasks in subtypes of children with attention deficit hyperactivity disorder. Journal of Clinical Child and Adolescent Psychology 34, 151162.
Berquin, PC, Giedd, JN, Jacobsen, LK, Hamburger, SD, Krain, AL, Rapoport, JL, Castellanos, FX (1998). Cerebellum in attention-deficit hyperactivity disorder: a morphometric MRI study. Neurology 50, 10871093.
Biederman, J, Faraone, SV, Monuteaux, MC, Bober, M, Cadogen, E (2004). Gender effects on attention-deficit/hyperactivity disorder in adults, revisited. Biological Psychiatry 55, 692700.
Bledsoe, JC, Semrud-Clikeman, M, Pliszka, SR (2011). Neuroanatomical and neuropsychological correlates of the cerebellum in children with attention-deficit/hyperactivity disorder – combined type. Journal of the American Academy of Child and Adolescent Psychiatry 50, 593601.
Block, RA, Hancock, PA, Zakay, D (2010). How cognitive load affects duration judgments: a meta-analytic review. Acta Psychologica 134, 330343.
Brett, M, Anton, J, Valabregue, R, Poline, J. (2002). Region of interest analysis using an SPM toolbox [Abstract]. Presented at the 8th International Conference on Functional Mapping of the Human Brain, 2–6 June 2002, Sendai, Japan.
Carmona, S, Hoekzema, E, Ramos-Quiroga, JA, Richarte, V, Canals, C, Bosch, R, Rovira, M, Carlos Soliva, J, Bulbena, A, Tobena, A, Casas, M, Vilarroya, O (2011). Response inhibition and reward anticipation in medication-naive adults with attention-deficit/hyperactivity disorder: a within-subject case-control neuroimaging study. Human Brain Mapping 33, 23502361.
Castellanos, FX, Lee, PP, Sharp, W, Jeffries, NO, Greenstein, DK, Clasen, LS, Blumenthal, JD, James, RS, Ebens, CL, Walter, JM, Zijdenbos, A, Evans, AC, Giedd, JN, Rapoport, JL (2002). Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. Journal of the American Medical Association 288, 17401748.
Diedrichsen, J, Balsters, JH, Flavell, J, Cussans, E, Ramnani, N (2009). A probabilistic MR atlas of the human cerebellum. Neuroimage 46, 3946.
Doyle, AE, Willcutt, EG, Seidman, LJ, Biederman, J, Chouinard, VA, Silva, J, Faraone, SV (2005). Attention-deficit/hyperactivity disorder endophenotypes. Biological Psychiatry 57, 13241335.
Egner, T, Hirsch, J (2005). Cognitive control mechanisms resolve conflict through cortical amplification of task-relevant information. Nature Neuroscience 8, 17841790.
Faraone, SV (2007). ADHD in adults – a familiar disease with unfamiliar challenges. CNS Spectrums 12, 1417.
Gottesman, II, Gould, TD (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. American Journal of Psychiatry 160, 636645.
Gualtieri, CT, Wargin, W, Kanoy, R, Patrick, K, Shen, CD, Youngblood, W, Mueller, RA, Breese, GR (1982). Clinical studies of methylphenidate serum levels in children and adults. Journal of the American Academy of Child Psychiatry 21, 1926.
Handy, TC, Gazzaniga, MS, Ivry, RB (2003). Cortical and subcortical contributions to the representation of temporal information. Neuropsychologia 41, 14611473.
Ivry, RB (1996). The representation of temporal information in perception and motor control. Current Opinion in Neurobiology 6, 851857.
Ivry, RB, Spencer, RM, Zelaznik, HN, Diedrichsen, J (2002). The cerebellum and event timing. Annals of the New York Academy of Sciences 978, 302317.
Kerns, KA, McInerney, RJ, Wilde, NJ (2001). Time reproduction, working memory, and behavioral inhibition in children with ADHD. Child Neuropsychology 7, 2131.
Kieling, C, Kieling, RR, Rohde, LA, Frick, PJ, Moffitt, T, Nigg, JT, Tannock, R, Castellanos, FX (2010). The age at onset of attention deficit hyperactivity disorder. American Journal of Psychiatry 167, 1416.
Klein, A, Andersson, J, Ardekani, BA, Ashburner, J, Avants, B, Chiang, MC, Christensen, GE, Collins, DL, Gee, J, Hellier, P, Song, JH, Jenkinson, M, Lepage, C, Rueckert, D, Thompson, P, Vercauteren, T, Woods, RP, Mann, JJ, Parsey, RV (2009). Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration. Neuroimage 46, 786802.
Leboyer, M, Leboyer, M, Bellivier, F, Jouvent, R, Nosten-Bertrand, M, Mallet, J, Pauls, D (1998). Psychiatric genetics: search for phenotypes. Trends in Neurosciences 21, 102105.
Maldjian, JA, Laurienti, PJ, Kraft, RA, Burdette, JH (2003). An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 19, 12331239.
Marx, I, Hubner, T, Herpertz, SC, Berger, C, Reuter, E, Kircher, T, Herpertz-Dahlmann, B, Konrad, K (2010). Cross-sectional evaluation of cognitive functioning in children, adolescents and young adults with ADHD. Journal of Neural Transmission 117, 403419.
Meck, WH, Penney, TB, Pouthas, V (2008). Cortico-striatal representation of time in animals and humans. Current Opinion in Neurobiology 18, 145152.
Mette, C, Grabemann, M, Zimmermann, M, Strunz, L, Scherbaum, N, Wiltfang, J, Kis, B (2015). No clear association between impaired short-term or working memory storage and time reproduction capacity in adult ADHD patients. PLoS ONE 10, e0133714.
Nelson, HE, O'Connell, A (1978). Dementia: the estimation of premorbid intelligence levels using the New Adult Reading Test. Cortex 14, 234244.
Rommelse, NN, Oosterlaan, J, Buitelaar, J, Faraone, SV, Sergeant, JA (2007). Time reproduction in children with ADHD and their nonaffected siblings. Journal of the American Academy of Child and Adolescent Psychiatry 46, 582590.
Rubia, K, Overmeyer, S, Taylor, E, Brammer, M, Williams, SC, Simmons, A, Bullmore, ET (1999). Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI. American Journal of Psychiatry 156, 891896.
Seidman, LJ, Doyle, A, Fried, R, Valera, E, Crum, K, Matthews, L (2004). Neuropsychological function in adults with attention-deficit/hyperactivity disorder. Psychiatric Clinics of North America 27, 261282.
Seidman, LJ, Valera, EM, Makris, N (2005). Structural brain imaging of attention-deficit/hyperactivity disorder. Biological Psychiatry 57, 12631272.
Sheehan, DV, Lecrubier, Y, Sheehan, KH, Amorim, P, Janavs, J, Weiller, E, Hergueta, T, Baker, R, Dunbar, GC (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry 59 (Suppl. 20), 2233; quiz 34–57.
Smith, A, Taylor, E, Lidzba, K, Rubia, K (2003). A right hemispheric frontocerebellar network for time discrimination of several hundreds of milliseconds. Neuroimage 20, 344350.
Smith, A, Taylor, E, Rogers, JW, Newman, S, Rubia, K (2002). Evidence for a pure time perception deficit in children with ADHD. Journal of Child Psychology and Psychiatry 43, 529542.
Stoodley, CJ (2012). The cerebellum and cognition: evidence from functional imaging studies. Cerebellum 11, 352365.
Stoodley, CJ, Schmahmann, JD (2009). Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. Neuroimage 44, 489501.
Toplak, ME, Dockstader, C, Tannock, R (2006). Temporal information processing in ADHD: findings to date and new methods. Journal of Neuroscience Methods 151, 1529.
Turner, DC, Blackwell, AD, Dowson, JH, McLean, A, Sahakian, BJ (2005). Neurocognitive effects of methylphenidate in adult attention-deficit/hyperactivity disorder. Psychopharmacology - Berlin 178, 286295.
Valera, EM, Spencer, RM, Zeffiro, TA, Makris, N, Spencer, TJ, Faraone, SV, Biederman, J, Seidman, LJ (2010). Neural substrates of impaired sensorimotor timing in adult attention-deficit/hyperactivity disorder. Biological Psychiatry 68, 359367.
Van Meel, CS, Oosterlaan, J, Heslenfeld, DJ, Sergeant, JA (2005). Motivational effects on motor timing in attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry 44, 451460.
West, J, Douglas, G, Houghton, S, Lawrence, V, Whiting, K, Glasgow, K (2000). Time perception in boys with attention-deficit/hyperactivity disorder according to time duration, distraction and mode of presentation. Child Neuropsychology 6, 241250.
Yang, B, Chan, RCK, Zou, X, Jing, J, Mai, J, Li, J (2007). Time perception deficit in children with ADHD. Brain Research 1170, 9096.

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