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The subtyping of schizophrenia in men and women: a latent class analysis

Published online by Cambridge University Press:  09 July 2009

D. J. Castle ,
P. C. Sham ,
S. Wessely  and
R. M. Murray
D. J. Castle*
Affiliation:
Genetics Section Institute of Psychiatry, London
P. C. Sham
Affiliation:
Genetics Section Institute of Psychiatry, London
S. Wessely
Affiliation:
Genetics Section Institute of Psychiatry, London
R. M. Murray
Affiliation:
Genetics Section Institute of Psychiatry, London
*
1Address for correspondence: Dr David J. Castle, Genetics Section, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF.
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Synopsis

Latent class analysis on an epidemiologically based series of 447 first contact patients with a broad diagnosis of schizophrenia revealed evidence for two subtypes: a ‘neurodevelopmental’ type characterized by early onset, poor pre-morbid social adjustment, restricted affect and a male: female ratio of 7:3; and a ‘paranoid’ type characterized by later onset, persecutory delusions and an almost equal sex ratio. A third ‘schizoaffective’ subtype, whose existence was less clear cut, was almost entirely confined to females and characterized by dysphoria and persecutory delusions, and had negligible familial risk of schizophrenia. The aetiological, biological and clinical significance of this typology remains to be tested.

Type
Original Articles
Information
Psychological Medicine , Volume 24 , Issue 1 , February 1994 , pp. 41 - 51
Copyright
Copyright © Cambridge University Press 1994

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