Hostname: page-component-76fb5796d-skm99 Total loading time: 0 Render date: 2024-04-26T06:18:08.411Z Has data issue: false hasContentIssue false
  • English
  • Français

Steady-state plasma concentrations during single and multiple dosage schedules of amitriptyline

Published online by Cambridge University Press:  09 July 2009

R. A. Braithwaite ,
B. R. S. Nakra  and
R. Gaind
R. A. Braithwaite*
Affiliation:
Poisons Unit and Department of Psychiatry, Guy's Hospital, London
B. R. S. Nakra
Affiliation:
Poisons Unit and Department of Psychiatry, Guy's Hospital, London
R. Gaind
Affiliation:
Poisons Unit and Department of Psychiatry, Guy's Hospital, London
*
1Address for correspondence: R. A. Braithwaite, Poisons Unit, Guy's Hospital, London S.E.l.
Get access Rights & Permissions [Opens in a new window]

Sysnopsis

Plasma amitriptyline and nortriptyline concentrations were measured in a group of five adult subjects who each received two different dosage regimes of amitriptyline (Tryptizol) for 14 day periods—namely, 25 mg three times daily and 75 mg once nightly. Mean steady-state plasma concentrations during the two dosage regimes were in close accord. The daily variation in drugplasma concentrations were only minimal during the thrice daily dosage regime but during the once nightly dosage regime there was an average decline in total drug plasma concentrations (amitriptyline plus nortriptyline) of about 30%. It was concluded that antidepressant medication with amitriptyline using a single nightly dose schedule might be more reliably taken by patients without there being any significant reduction in therapeutic efficacy.

Type
Preliminary communication
Information
Psychological Medicine , Volume 4 , Issue 3 , August 1974 , pp. 338 - 341
Copyright
Copyright © Cambridge University Press 1974

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Alexanderson, B., Price Evans, D. A., and Sjöqvist, F. (1969). Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy. British Medical Journal, 4, 764–768.Google Scholar
Braithwaite, R. A., Goulding, R., Theano, G'., Bailey, J., and Coppen, A. (1972). Plasma concentration of amitriptyline and clinical response. Lancet, 1, 1297–1300.CrossRefGoogle ScholarPubMed
Braithwaite, R. A., and Widdop, B. (1971). A specific gaschromatographic method for the measurement of “steadystate” plasma levels of amitriptyline and nortriptyline in patients. Clinica Chimica Acta, 35, 461–472.Google Scholar
Coppen, A., Bailey, J. E., and White, S. G. (1969). Slowrelease lithium carbonate. Journal of Clinical Pharmacology, 9, 160–162.Google ScholarPubMed
General Practitioner Clinical Trial (1970). Dosage schedules in general practice. Practitioner, 204, 719–723.Google Scholar
Gram, L. F., and Fredricson-Overø, K. (1972). Drug interaction: inhibitory effect of neuroleptics on metabolism of tricyclic antidepressants in man. British Medical Journal, 1, 463–465.CrossRefGoogle ScholarPubMed
Hammer, W., Ideström, C.-M., and Sjöqvist, F. (1967). Chemical control of antidepressant drug therapy. In Antidepressant Drugs, pp. 301–310. Edited by Garattini, S. and Dukes, M. N. G.. International Congress Series No. 122. Excerpta Medica: Amsterdam.Google Scholar
Hammer, W., and Sjöqvist, F. (1967). Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds. Life Sciences, 6, 1895–1903.CrossRefGoogle ScholarPubMed
Johnson, D. A. W. (1973). Treatment of depression in general practice. British Medical Journal, 2, 18–20.CrossRefGoogle ScholarPubMed
Kramer, J. C. (1962). Single daily dose schedules of imipramine (Tofranil). Comprehensire Psychiatry, 3, 191–192.Google Scholar
Mendels, J. and Digiacomo, J. (1973). The treatment of depression with a single daily dose of imipramine pamoate. American Journal of Psychiatry, 130, 1022–1024.Google Scholar
Mindham, R. H. S., Howland, C., and Shepherd, M. (1973). An evaluation of continuation therapy with tricyclic antidepressants in depressive illness. Psychological Medicine, 3, 5–17.CrossRefGoogle ScholarPubMed
Saraf, K., and Klein, D. F. (1971). The safety of a single daily dose schedule for imipramine. American Journal of Psychiatry, 128, 483–484.CrossRefGoogle ScholarPubMed
Sims, A. C. P. (1972). Trial of a sustained release form of amitriptyline in the treatment of depressive illness. British Journal of Psychiatry, 120, 65–67.CrossRefGoogle ScholarPubMed
Sjöqvist, F., Hammer, W., Ideström, C.-M., Lind, M., Tuck, D., and Åsberg, M. (1968). Plasma level of monomethylated tricyclic antidepressants and side-effects in man. In Toxicity and Side-Effects of Psychotropic Drugs, pp. 246–257. International Congress Series, No. 145. Excerpta Medica: Amsterdam.Google Scholar
Wagner, J. G. (1971). Biopharmaceiitics and Relevant Pharmacokinetics, p. 244. Drug Intelligence Publications: Hamilton, III.Google Scholar
Willcox, D. R. C., Gillan, R., and Hare, E. H. (1965). Do psychiatric out-patients take their drugs? British Medical Journal, 2, 790–792.CrossRefGoogle Scholar