Skip to main content Accessibility help
×
Home

Psychotic reactions to daily life stress and dopamine function in people with severe hearing impairment

  • M. J. Gevonden (a1) (a2) (a3), I. Myin-Germeys (a1), W. van den Brink (a4), J. van Os (a1) (a5), J. P. Selten (a1) (a2) and J. Booij (a3)...

Abstract

Background.

Minor stresses measured in daily life have repeatedly been associated with increased momentary psychotic experiences, both in individuals with psychotic disorders and in persons who are genetically at an increased risk for these disorders. Severe hearing impairment (SHI) is an environmental risk factor for psychotic disorder, possibly due to the experience of social exclusion. The aim of the current study is to investigate whether people with SHI exhibit higher levels of psychotic reactivity to social stressors in daily life than normal-hearing controls and whether this reactivity is associated with decreased baseline dopamine (DA) D2/3 receptor availability and/or elevated DA release following a dexamphetamine challenge.

Method.

We conducted an experience sampling study in 15 young adults with SHI and 19 matched normal-hearing controls who had previously participated in a single photon emission computed tomography study measuring DA D2/3 receptor availability and DA release in response to dexamphetamine.

Results.

The association between social stress and momentary psychotic experiences in daily life was stronger among SHI participants than among normal-hearing controls. Interactions between social stress and baseline striatal DA D2/3 receptor availability or DA release were not significant in multilevel models of momentary psychotic experiences including age, sex and tobacco use.

Conclusions.

While both elevated striatal DA release and elevated psychotic stress reactivity have been found in the same population defined by an environmental risk factor, SHI, their inter-relationship cannot be established. Further research is warranted to clarify the association between biological and psychological endophenotypes and psychosis risk.

Copyright

Corresponding author

* Address for correspondence: M. J. Gevonden, M.Sc., Department of Nuclear Medicine, Academic Medical Center, PO Box 22660, 1100 DD, Amsterdam, The Netherlands. (Email: m.gevonden@maastrichtuniversity.nl)

References

Hide All
Allan, S, Gilbert, P (1995). A social comparison scale: psychometric properties and relationship to psychopathology. Personality and Individual Differences 19, 293299.
Booij, J, Korn, P, Linszen, DH, van Royen, EA (1997). Assessment of endogenous dopamine release by methylphenidate challenge using iodine-123 iodobenzamide single-photon emission tomography. European Journal of Nuclear Medicine and Molecular Imaging 24, 674677.
Brunelin, J, d’ Amato, T, Brun, P, Bediou, B, Kallel, L, Senn, M, Poulet, E, Saoud, M (2007). Impaired verbal source monitoring in schizophrenia: an intermediate trait vulnerability marker? Schizophrenia Research 89, 287292.
Brunelin, J, Fecteau, S, Suaud-Chagny, M-F (2013). Abnormal striatal dopamine transmission in schizophrenia. Current Medicinal Chemistry 20, 397404.
Collip, D, Myin-Germeys, I, Van Os, J (2008). Does the concept of “sensitization” provide a plausible mechanism for the putative link between the environment and schizophrenia? Schizophrenia Bulletin 34, 220.
Cooper, AF (1976). Deafness and psychiatric illness. British Journal of Psychiatry 129, 216.
David, A, Malmberg, A, Lewis, G, Brandt, L, Allebeck, P (1995). Are there neurological and sensory risk factors for schizophrenia? Schizophrenia Research 14, 247251.
Delespaul, PA (1995). Assessing Schizophrenia in Daily Life. UPM, Universitaire Pers Maastricht: Maastricht.
Egerton, A, Chaddock, CA, Winton-Brown, TT, Bloomfield, MAP, Bhattacharyya, S, Allen, P, McGuire, PK, Howes, OD (2013). Presynaptic striatal dopamine dysfunction in people at ultra-high risk for psychosis: findings in a second cohort. Biological Psychiatry 74, 106112.
Fehr, MD, Yakushev, MD, Hohmann, DP, Buchholz, MS, Landvogt, MD, Deckers, H, Eberhardt, A, Kläger, M, Smolka, MD, Scheurich, PD, Dielentheis, MD, Schmidt, MD, Rösch, PD, Bartenstein, MD, Gründer, MD, Schreckenberger, MD (2008). Association of low striatal dopamine D2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse. American Journal of Psychiatry 165, 507514.
Fellinger, J, Holzinger, D, Gerich, J, Goldberg, D (2007). Mental distress and quality of life in the hard of hearing. Acta Psychiatrica Scandinavica 115, 243245.
Fors, A, Abel, KM, Wicks, S, Magnusson, C, Dalman, C (2013). Hearing and speech impairment at age 4 and risk of later non-affective psychosis. Psychological Medicine 43, 20672076.
Garety, PA, Bebbington, P, Fowler, D, Freeman, D, Kuipers, E (2007). Implications for neurobiological research of cognitive models of psychosis: a theoretical paper. Psychological Medicine 37, 13771391.
Garety, PA, Kuipers, E, Fowler, D, Freeman, D, Bebbington, PE (2001). A cognitive model of the positive symptoms of psychosis. Psychological Medicine 31, 189195.
Gevonden, M, Booij, J, van den Brink, W, Heijtel, D, van Os, J, Selten, J (2014a). Increased release of dopamine in the striata of young adults with hearing impairment and its relevance for the social defeat hypothesis of schizophrenia. JAMA Psychiatry. Published online 01 10 2014 . doi:10.1001/jamapsychiatry.2014.1325.
Gevonden, MJ, Selten, JP, Myin-Germeys, I, de Graaf, R, Ten Have, M, van Dorsselaer, S, van Os, J, Veling, W (2014 b). Sexual minority status and psychotic symptoms: findings from the Netherlands Mental Health Survey and Incidence Studies (NEMESIS). Psychological Medicine 44, 421434.
Gilbert, P, Allan, S (1998). The role of defeat and entrapment (arrested flight) in depression: an exploration of an evolutionary view. Psychological Medicine 28, 585598.
Goldstein, H (2005). Multilevel models. In Encyclopedia of Biostatistics (ed. Goldstein, H.). John Wiley & Sons, Ltd: Chichester. http://onlinelibrary.wiley.com/doi/10.1002/0470011815.b2a09031/abstract
Hasson, D, Theorell, T, Wallén, MB, Leineweber, C, Canlon, B (2011). Stress and prevalence of hearing problems in the Swedish working population. BMC Public Health 11, 130.
Howes, OD, Montgomery, AJ, Asselin, M-C, Murray, RM, Valli, I, Tabraham, P, Bramon-Bosch, E, Valmaggia, L, Johns, L, Broome, M, McGuire, PK, Grasby, PM (2009). Elevated striatal dopamine function linked to prodromal signs of schizophrenia. Archives of General Psychiatry 66, 1320.
Järvelin, MR, Mäki-Torkko, E, Sorri, MJ, Rantakallio, PT (1997). Effect of hearing impairment on educational outcomes and employment up to the age of 25 years in northern Finland. British Journal of Audiology 31, 165175.
Keefe, RSE, Arnold, MC, Bayen, UJ, Harvey, PD (1999). Source monitoring deficits in patients with schizophrenia; a multinomial modelling analysis. Psychological Medicine 29, 903914.
Kegeles, LS, Abi-Dargham, A, Frankle, WG, Gil, R, Cooper, TB, Slifstein, M, Hwang, D-R, Huang, Y, Haber, SN, Laruelle, M (2010). Increased synaptic dopamine function in associative regions of the striatum in schizophrenia. Archives of General Psychiatry 67, 231239.
Lardinois, M, Lataster, T, Mengelers, R, Van Os, J, Myin-Germeys, I (2011). Childhood trauma and increased stress sensitivity in psychosis. Acta Psychiatrica Scandinavica 123, 2835.
Laruelle, M, Abi-Dargham, A, Gil, R, Kegeles, L, Innis, R (1999). Increased dopamine transmission in schizophrenia: relationship to illness phases. Biological Psychiatry 46, 5672.
Laruelle, M, Abi-Dargham, A, van Dyck, CH, Rosenblatt, W, Zea-Ponce, Y, Zoghbi, SS, Baldwin, RM, Charney, DS, Hoffer, PB, Kung, HF, Innis, RB (1995). SPECT imaging of striatal dopamine release after amphetamine challenge. Journal of Nuclear Medicine 36, 11821190.
Lataster, J, Collip, D, Ceccarini, J, Haas, D, Booij, L, van Os, J, Pruessner, J, Van Laere, K, Myin-Germeys, I (2011). Psychosocial stress is associated with in vivo dopamine release in human ventromedial prefrontal cortex: a positron emission tomography study using [18F]fallypride. NeuroImage 58, 10811089.
Lataster, T, Valmaggia, L, Lardinois, M, van Os, J, Myin-Germeys, I (2013). Increased stress reactivity: a mechanism specifically associated with the positive symptoms of psychotic disorder. Psychological Medicine 43, 13891400.
Martinez, D, Slifstein, M, Broft, A, Mawlawi, O, Hwang, D-R, Huang, Y, Cooper, T, Kegeles, L, Zarahn, E, Abi-Dargham, A, Haber, SN, Laruelle, M (2003). Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum. Journal of Cerebral Blood Flow and Metabolism 23, 285300.
Mathers, CD, Fat, DM, Boerma, J (2008). The Global Burden of Disease: 2004 Update. World Health Organization: Geneva.
Mathers, CD, Loncar, D (2006). Projections of global mortality and burden of disease from 2002 to 2030. PLoS Medicine 3, e442.
Mawlawi, O, Martinez, D, Slifstein, M, Broft, A, Chatterjee, R, Hwang, D-R, Huang, Y, Simpson, N, Ngo, K, Van Heertum, R, Laruelle, M (2001). Imaging human mesolimbic dopamine transmission with positron emission tomography: I. Accuracy and precision of D 2 receptor parameter measurements in ventral striatum. Journal of Cerebral Blood Flow and Metabolism 21, 10341057.
Meyer, IH (2003). Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Psychological Bulletin 129, 674697.
Mizrahi, R, Addington, J, Rusjan, PM, Suridjan, I, Ng, A, Boileau, I, Pruessner, JC, Remington, G, Houle, S, Wilson, AA (2012). Increased stress-induced dopamine release in psychosis. Biological Psychiatry 71, 561567.
Myin-Germeys, I, Delespaul, P, Van Os, J (2005 a). Behavioural sensitization to daily life stress in psychosis. Psychological Medicine 35, 733741.
Myin-Germeys, I, Krabbendam, L, Delespaul, PA, Van Os, J (2003). Do life events have their effect on psychosis by influencing the emotional reactivity to daily life stress? Psychological Medicine 33, 327333.
Myin-Germeys, I, Marcelis, M, Krabbendam, L, Delespaul, P, van Os, J (2005 b). Subtle fluctuations in psychotic phenomena as functional states of abnormal dopamine reactivity in individuals at risk. Biological Psychiatry 58, 105110.
Myin-Germeys, I, Oorschot, M, Collip, D, Lataster, J, Delespaul, P, van Os, J (2009). Experience sampling research in psychopathology: opening the black box of daily life. Psychological Medicine 39, 15331547.
Myin-Germeys, I, van Os, J (2007). Stress-reactivity in psychosis: evidence for an affective pathway to psychosis. Clinical Psychology Review 27, 409424.
Myin-Germeys, I, van Os, J, Schwartz, JE, Stone, AA, Delespaul, PA (2001). Emotional reactivity to daily life stress in psychosis. Archives of General Psychiatry 58, 11371144.
Palmier-Claus, JE, Myin-Germeys, I, Barkus, E, Bentley, L, Udachina, A, Delespaul, PA, Lewis, SW, Dunn, G (2011). Experience sampling research in individuals with mental illness: reflections and guidance. Acta Psychiatrica Scandinavica 123, 1220.
Pierre, PV, Fridberger, A, Wikman, A, Alexanderson, K (2012). Self-reported hearing difficulties, main income sources, and socio-economic status; a cross-sectional population-based study in Sweden. BMC Public Health 12, 874.
Pohjalainen, T, Rinne, JO, Någren, K, Syvälahti, E, Hietala, J (1998). Sex differences in the striatal dopamine D2 receptor binding characteristics in vivo . American Journal of Psychiatry 155, 768773.
Pruessner, JC, Champagne, F, Meaney, MJ, Dagher, A (2004). Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]raclopride. Journal of Neuroscience 24, 28252831.
Rinne, JO, Hietala, J, Ruotsalainen, U, Säkö, E, Laihinen, A, Någren, K, Lehikoinen, P, Oikonen, V, Syvälahti, E (1993). Decrease in human striatal dopamine D2 receptor density with age: a PET study with [11C]raclopride. Journal of Cerebral Blood Flow and Metabolism 13, 310314.
Russell, DW (1996). UCLA Loneliness Scale (version 3): reliability, validity, and factor structure. Journal of Personality Assessment 66, 2040.
Schmand, BA, Bakker, D, Saan, RJ, Louman, J (1991). De Nederlandse Leestest voor Volwassenen: een maat voor het premorbide intelligentieniveau (The Dutch Reading Test for Adults: a measure of premorbid intelligence level). Tijdschrift voor Gerontologie en Geriatrie 22, 1519.
Schwartz, JE, Stone, AA (1998). Strategies for analyzing ecological momentary assessment data. Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association 17, 616.
Selten, J-P, Cantor-Graae, E (2007). Hypothesis: social defeat is a risk factor for schizophrenia? British Journal of Psychiatry 191, s9s12.
Selten, JP, van der Ven, E, Rutten, BP, Cantor-Graae, E (2013). The social defeat hypothesis of schizophrenia: an update. Schizophrenia Bulletin 39, 11801186.
Snijders, TAB, Bosker, RJ (1999). Multilevel Analysis: An Introduction to Basic and Advanced Multilevel Modeling, pp. 23, 341–342. Sage Publications: London.
Soliman, A, O'Driscoll, GA, Pruessner, J, Holahan, A-LV, Boileau, I, Gagnon, D, Dagher, A (2008). Stress-induced dopamine release in humans at risk of psychosis: a [ 11C]raclopride PET study. Neuropsychopharmacology 33, 20332041.
Stam, M, Kostense, PJ, Festen, JM, Kramer, SE (2013). The relationship between hearing status and the participation in different categories of work: demographics. Work 46, 207219.
Stefanis, N, Thewissen, V, Bakoula, C, van Os, J, Myin-Germeys, I (2006). Hearing impairment and psychosis: a replication in a cohort of young adults. Schizophrenia Research 85, 266272.
Stevens, G, Flaxman, S, Brunskill, E, Mascarenhas, M, Mathers, CD, Finucane, M (2013). Global and regional hearing impairment prevalence: an analysis of 42 studies in 29 countries. European Journal of Public Health 23, 146152.
Sweeting, H, West, P (2001). Being different: correlates of the experience of teasing and bullying at age 11. Research Papers in Education 16, 225246.
Velthorst, E, Levine, SZ, Henquet, C, de Haan, L, van Os, J, Myin-Germeys, I, Reichenberg, A (2013). To cut a short test even shorter: Reliability and validity of a brief assessment of intellectual ability in Schizophrenia – a control-case family study. Cognitive Neuropsychiatry 18, 574593.
Van der Werf, M, Thewissen, V, Dominguez, MD, Lieb, R, Wittchen, H, van Os, J (2011). Adolescent development of psychosis as an outcome of hearing impairment: a 10-year longitudinal study. Psychological Medicine 41, 477485.
Van der Werf, M, van Boxtel, M, Verhey, F, Jolles, J, Thewissen, V, van Os, J (2007). Mild hearing impairment and psychotic experiences in a normal aging population. Schizophrenia Research 94, 180186.

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed