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Precursors and metabolites of 5-hydroxytryptamine and dopamine in the ventricular cerebrospinal fluid of psychiatric patients

  • P. K. Bridges (a1), J. R. Bartlett (a1), P. Sepping (a1), B. D. Kantamaneni (a1) and G. Curzon (a1)...

Synopsis

Tryptophan and 5-hydroxyindoleacetic acid (precursor and metabolite respectively of 5-hydroxytryptaminę) were determined in ventricular CSF of psychiatric patients undergoing stereotactic subcaudate tractotomy. Tyrosine and homovanillic acid (precursor and metabolite respectively of dopamine) were also determined. Results suggest an association between affective state and the above precursor amino acids with lower concentrations in primary depression and higher ones when anxiety or agitation predominate. This leads to lower 5-hydroxyindoleacetic acid concentrations in depression and higher concentrations in anxiety and agitation.

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Corresponding author

1Address for correspondence: Dr G. Curzon, Department of Neurochemistry, Institute of Neurology, London WC1 3BG.

References

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Ashcroft, G. W., Crawford, T. B. B., Eccleston, D., Sharman, D. F., MacDougall, E. J., Stanton, J. B. & Binns, J. F. (1966). 5-Hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases. Lancet ii, 10491052.
Ashcroft, G. W., Blackburn, I. M., Eccleston, D., Glen, A. I. M., Hartley, W., Kinloch, N. E., Lonergan, M., Murray, L. G. & Pullar, I. A. (1973). Changes on recovery in the concentrations of tryptophan and the biogenic amine metabolites in the cerebrospinal fluid of patients with affective illness. Psychological Medicine 3, 319325.
Bloxam, D. L. & Warren, W. H. (1974). Error in the determination of tryptophan by the method of Denckla and Dewey. A revised procedure. Analytical Biochemistry 60, 621625.
Bridges, P. K. & Bartlett, J. R. (1973). The work of a psycho-surgical unit. Postgraduate Medical Journal 49, 855859.
Broadhurst, A. D. (1970). L-Tryptophan versus ECT. Lancet i, 13921393.
Carroll, B. J., Mowbray, R. M. & Davies, B. (1970). Sequential comparison of l-tryptophan with ECT in severe depression. Lancet i, 967969.
Coppen, A., Shaw, D. M., Herzberg, B. & Maggs, R. (1967). Tryptophan in the treatment of depression. Lancet ii, 11781180.
Coppen, A., Brooksbank, B. W. L. & Peet, M. (1972). Tryptophan concentration in the cerebrospinal fluid of depressive patients. Lancet i, 1393.
Coppen, A., Eccleston, E. G. & Peet, M. (1973). Total and free tryptophan concentration in the plasma of depressive patients. Lancet ii, 6063.
Curzon, G. & Knott, P.J. (1974). Fatty acids and the disposition of tryptophan. In Aromatic Amino Acids in the Brain (ed. Wurtman, R. J.), pp. 218229. Ciba Foundation Symposium.
Curzon, G., Godwin-Austen, R. B., Tomlinson, E. B. & Kantamaneni, B. D. (1970). The cerebrospinal fluid homo-vanillic acid concentration in patients with Parkinsonism treated with L-dopa. Journal of Neurology, Neurosurgery and Psychiatry 33, 16.
Dominic, J. A., Sinha, A. K. & Barchas, J. D. (1975). Effect of benzodiazepine compounds on brain amine metabolism. European Journal of Pharmacology 32, 124127.
Eccleston, D., Ashcroft, G. W., Crawford, T. B. B., Stanton, J. B., Wood, D. & McTurk, P. H. (1970). Effect of tryptophan administration on 5HIAA in cerebrospinal fluid in man. Journal of Neurology, Neurosurgery and Psychiatry 33, 269272.
Faires, R. A. & Parkes, B. H. (1960). Radioisotope Laboratory Techniques, 2nd ed., p. 165. Newnes: London.
Fernstrom, J. D., Shabshelowitz, H. & Faller, D. V. (1974). Diazepam increases 5-hydroxyindole concentrations in rat brain and spinal cord. Life Sciences 15, 15771584.
Friedman, P. A., Kappelman, A. H. & Kaufman, S. (1972). Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain. Journal of Biological Chemistry 247, 41654173.
Garelis, E., Young, S. N., Lal, S. & Sourkes, T. L. (1974). Monoamine metabolites in lumbar CSF: the question of their origin in relation to clinical studies. Brain Research 79, 18.
Gessa, G. L. & Tagliamonte, A. (1974). Possible role of free serum tryptophan in the control of brain tryptophan level and serotonin synthesis. Advances in Biochemical Psycho-pharmacy 11, 119131.
Göktepe, E. O., Young, L. B. & Bridges, P. K. (1975). A further review of the results of stereotactic subcaudate tractotomy. British Journal Psychiatry 126, 270280.
Herrington, R. N., Bruce, A., Johnstone, E. C. & Lader, M. H. (1974). Comparative trial of L-tryptophan and ECT in severe depressive illness. Lancet ii, 731734.
Knight, G. C. (1969). Bi-frontal stereotactic tractotomy: an atraumatic operation of value in the treatment of intractable psychoneurosis. British Journal of Psychiatry 115 257266.
Korf, J. & Valkenburgh-Sikkema, T. (1969). Fluorimetric determination of 5-hydroxyindoleacetic acid in human urine and cerebrospinal fluid. Clinica chimica acta 26, 301306.
Modigh, K. (1975). The relationship between the concentrations of tryptophan and 5-hydroxyindoleacetic acid in rat brain and cerebrospinal fluid. Journal of Neurochemistry 25, 351352.
Post, R. M., Kotin, J., Goodwin, F. K. & Gordon, E. K. (1973). Psychomotor activity and cerebrospinal fluid amine metabolites in affective illness. American Journal of Psychiatry 130, 6772.
Waalkes, T. P. & Udenfriend, S. (1957). A fluorometric method for the estimation of tyrosine in plasma and tissues. Journal of Laboratory and Clinical Medicine 50, 733736.
West, K. A., Edvinsson, L., Nielsen, K. C. & Roos, B. E. (1972). Concentration of acid monoamine metabolites in ventricular CSF of patients with posterior fossa tumours. In Intracranial Pressure (ed. Brock, M. & Dietz, H.), pp. 331337. Springer: Berlin.
Young, S. N., Garelis, E., Lal, S., Martin, J. B., Molina-Negro, P., Ethier, R. & Sourkes, T. L. (1974). Tryptophan and 5-hydroxyindoleacetic acid in human cerebrospinal fluid. Journal of Neurochemistry 22, 777779.
Young, S. N., Lal, S., Sourkes, T. L., Feldmuller, F., Aronoff, A. & Martin, J. B. (1975). Relationships between tryptophan in serum and CSF, and 5-hydroxyindoleacetic acid in CSF of man: effect of cirrhosis of liver and probenecid administration. Journal of Neurology, Neurosurgery and Psychiatry 38, 322330.

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