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Precursors and metabolites of 5-hydroxytryptamine and dopamine in the ventricular cerebrospinal fluid of psychiatric patients

Published online by Cambridge University Press:  09 July 2009

P. K. Bridges ,
J. R. Bartlett ,
P. Sepping ,
B. D. Kantamaneni  and
G. Curzon
P. K. Bridges
Affiliation:
Geoffrey Knight Psychosurgical Unit, Brook General Hospital, London, Department of Neurochemistry, Institute of Neurology, London
J. R. Bartlett
Affiliation:
Geoffrey Knight Psychosurgical Unit, Brook General Hospital, London, Department of Neurochemistry, Institute of Neurology, London
P. Sepping
Affiliation:
Geoffrey Knight Psychosurgical Unit, Brook General Hospital, London, Department of Neurochemistry, Institute of Neurology, London
B. D. Kantamaneni
Affiliation:
Geoffrey Knight Psychosurgical Unit, Brook General Hospital, London, Department of Neurochemistry, Institute of Neurology, London
G. Curzon*
Affiliation:
Geoffrey Knight Psychosurgical Unit, Brook General Hospital, London, Department of Neurochemistry, Institute of Neurology, London
*
1Address for correspondence: Dr G. Curzon, Department of Neurochemistry, Institute of Neurology, London WC1 3BG.
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Synopsis

Tryptophan and 5-hydroxyindoleacetic acid (precursor and metabolite respectively of 5-hydroxytryptaminę) were determined in ventricular CSF of psychiatric patients undergoing stereotactic subcaudate tractotomy. Tyrosine and homovanillic acid (precursor and metabolite respectively of dopamine) were also determined. Results suggest an association between affective state and the above precursor amino acids with lower concentrations in primary depression and higher ones when anxiety or agitation predominate. This leads to lower 5-hydroxyindoleacetic acid concentrations in depression and higher concentrations in anxiety and agitation.

Type
Research Article
Information
Psychological Medicine , Volume 6 , Issue 3 , August 1976 , pp. 399 - 405
Copyright
Copyright © Cambridge University Press 1976

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