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Parental depression and offspring psychopathology: a Children of Twins study

  • A. L. Singh (a1), B. M. D'Onofrio (a1), W. S. Slutske (a2), E. Turkheimer (a3), R. E. Emery (a3), K. P. Harden (a3), A. C. Heath (a4), P. A. F. Madden (a4), D. J. Statham (a5) (a6) and N. G. Martin (a5)...

Abstract

Background

Associations between parental depression and offspring affective and disruptive disorders are well documented. Few genetically informed studies have explored the processes underlying intergenerational associations.

Method

A semi-structured interview assessing DSM-III-R psychiatric disorders was administered to twins (n=1296) from the Australian Twin Register (ATR), their spouses (n=1046) and offspring (n=2555). We used the Children of Twins (CoT) design to delineate the extent to which intergenerational associations were consistent with a causal influence or due to genetic confounds.

Results

In between-family analyses, parental depression was associated significantly with offspring depression [hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.20–1.93] and conduct disorder (CD; HR 2.27, CI 1.31–3.93). Survival analysis indicated that the intergenerational transmission of depression is consistent with a causal (environmental) inference, with a significant intergenerational association in offspring of discordant monozygotic (MZ) twin pairs (HR 1.39, CI 1.00–1.94). Logistic regression analysis suggested that the parental depression–offspring CD association was due to shared genetic liability in the parents and offspring. No intergenerational association was found when comparing the offspring of discordant MZ twins [odds ratio (OR) 1.41, CI 0.63–3.14], but offspring of discordant dizygotic (DZ) twins differed in their rates of CD (OR 2.53, CI 0.95–6.76). All findings remained after controlling for several measured covariates, including history of depression and CD in the twins' spouses.

Conclusions

The mechanisms underlying associations between parental depression and offspring psychopathology seem to differ depending on the outcome. The results are consistent with a causal environmental role of parental depression in offspring depression whereas common genetic factors account for the association of parental depression and offspring CD.

Copyright

Corresponding author

*Address for correspondence: A. L. Singh, Ph.D., Department of Psychological and Brain Sciences, Indiana University, 1101 E. Tenth Street, Bloomington, IN 47405, USA. (Email: singh25@indiana.edu)

References

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Beardslee, WR, Versage, EM, Gladstone, T (1998). Children of affectively ill parents: a review of the past 10 years. Journal of the American Academy of Child and Adolescent Psychiatry 37, 11341141.
Bierut, LJ, Heath, AC, Bucholz, KK, Dinwiddie, SH, Madden, PAF, Statham, DJ, Dunne, MP, Martin, NG (1999). Major depressive disorder in a community-based twin sample: are there different genetic and environmental contributions for men and women? Archives of General Psychiatry 56, 557563.
Brennan, PA, Hammen, C, Katz, AR, Le Brocque, RM (2002). Maternal depression, paternal psychopathology, and adolescent diagnostic outcomes. Journal of Consulting and Clinical Psychology 70, 10751085.
Bucholz, KK, Cadoret, R, Cloninger, CR, Dinwiddie, SH, Hesselbrock, VM, Nurnberger, JIJ, Reich, T, Schmidt, I, Schuckit, MA (1994). A new semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. Journal of Studies on Alcohol 55, 149158.
Cadoret, RJ, O'Gorman, TW, Heywood, E, Troughton, E (1985). Genetic and environmental factors in major depression. Journal of Affective Disorders 9, 155164.
Carragher, N, Adamson, G, Bunting, B, McCann, S (2009). Subtypes of depression in a nationally representative sample. Journal of Affective Disorders 113, 8899.
Connell, AM, Goodman, SH (2002). The association between psychopathology in fathers versus mothers and children's internalizing and externalizing behavior problems: a meta-analysis. Psychological Bulletin 128, 746773.
Cummings, EM, Keller, PS, Davies, M (2005). Towards a family process model of maternal and paternal depressive symptoms: exploring multiple relations with child and family functioning. Journal of Child Psychology and Psychiatry 46, 479489.
D'Onofrio, BM (2005). Children of Twins design. In Encyclopedia of Statistics in Behavioral Science (ed. Everitt, B. S. and Howell, D. C.), pp. 256258. John Wiley & Sons, Ltd: Hoboken, N.J.
D'Onofrio, BM, Slutske, W, Turkheimer, E, Emery, R, Heath, A, Madden, PAF, Martin, NJ (2007 a). The intergenerational transmission of childhood conduct problems: a Children of Twins study. Archives of General Psychiatry 64, 820829.
D'Onofrio, BM, Turkheimer, E, Eaves, L, Corey, L, Berg, K, Solaas, MH, Emery, R (2003). The role of the Children of Twins design in elucidating causal relations between parent characteristics and child outcomes. Journal of Child Psychology and Psychiatry 44, 11301144.
D'Onofrio, BM, Turkheimer, E, Emery, RE, Harden, KP, Slutske, WS, Heath, AC, Madden, PAF, Martin, NG (2007 b). A genetically informed study of the intergenerational transmission of marital instability. Journal of Marriage and Family 69, 793809.
D'Onofrio, BM, Turkheimer, E, Emery, R, Slutske, W, Heath, AC, Madden, P, Martin, N (2005). A genetically informed study of marital instability and its association with offspring psychopathology. Journal of Abnormal Psychology 114, 570586.
Eaves, L, Silberg, J, Maes, H (2005). Revisiting the Children of Twins: can they be used to resolve the environmental effects of dyadic parental treatment on child behavior? Twin Research and Human Genetics 8, 283290.
Eaves, LJ, Silberg, JL, Maes, HH, Simonoff, E, Pickles, A, Rutter, M, Neale, MC, Reynolds, CA, Erikson, MT, Heath, AC, Loeber, R, Truett, KR, Hewitt, JK (1997). Genetics and developmental psychopathology: 2. The main effects of genes and environment on behavioral problems in the Virginia Twin Study of Adolescent Behavioral Development. Journal of Child Psychology and Psychiatry and Allied Disciplines 38, 965980.
Eley, TC, Stevenson, J (1999). Exploring the covariation between anxiety and depression symptoms: a genetic analysis of the effects of age and sex. Journal of Child Psychology and Psychiatry and Allied Disciplines 40, 12731282.
Foster, CE, Webster, MC, Weissman, MM, Pilowsky, DJ, Wickramarante, P, Rush, AJ, Hughes, CW, Garber, J, Malloy, E, Cerda, G, Kornstein, SG, Alpert, JE, Wisniewski, SR, Trivedi, MH, Fava, M, King, CA (2008). Course and severity of maternal depression: associations with family functioning and child adjustment. Journal of Youth and Adolescence 37, 906916.
Goodman, SH, Gotlib, IH (1999). Risk for psychopathology in the children of depressed mothers: a developmental model for understanding mechanisms of transmission. Psychological Review 106, 458490.
Goodman, SH, Tully, E (2006). Depression in women who are mothes: an integrative model of risk for the development of psychopathology in their sons and daughters. In Women and Depression: A Handbook for the Social, Behavioral, and Biomedical Sciences (ed. Keyes, C. L. M. and Goodman, S. H.), pp. 241280. Cambridge University Press: New York.
Gottesman, II, Bertelsen, A (1989). Confirming unexpressed genotypes for schizophrenia. Archives of General Psychiatry 46, 867872.
Harden, KP, Turkheimer, E, Emery, RE, D'Onofrio, BM, Slutske, WS, Heath, AC, Martin, NG (2007). Marital conflict and conduct disorder in Children-of-Twins. Child Development 78, 118.
Harrington, R, Rutter, M, Fombonne, E (1996). Developmental pathways in depression: multiple meanings, antecedents, and endpoints. Development and Psychopathology 8, 601616.
Heath, AC, Bucholz, KK, Madden, PA, Dinwiddie, SH, Slutske, WS, Bierut, LJ, Statham, DJ, Dunne, MP, Whitfield, JB, Martin, NG (1997). Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychological Medicine 27, 13811396.
Heath, AC, Kendler, KS, Eaves, LJ, Markell, D (1985). The resolution of cultural and biological inheritance: informativeness of different relationships. Behavior Genetics 15, 439465.
Heath, AC, Madden, PAF, Martin, NG (1998). Assessing the effects of cooperation bias and attrition in behavioral genetic research using data-weighting. Behavior Genetics 28, 415427.
Heath, AC, Martin, NG (1994). Genetic influences on alcohol consumption patterns and problem drinking: results from the Australian NHMRC Twin Panel Follow-Up Survey. Annals of the New York Academy of Sciences 708, 7285.
Jardine, R, Martin, NG (1984). Causes of variation in drinking habits in a large twin sample. Acta Geneticae Medicae et Gemellologiae 33, 435450.
Kane, P, Garber, J (2004). The relations among depression in fathers, children's psychopathology, and father-child conflict: a meta-analysis. Clinical Psychology Review 24, 339360.
Kendler, KS, Gardner, CO, Neale, MC, Prescott, CA (2001). Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes? Psychological Medicine 31, 605616.
Kendler, KS, Gardner, CO, Prescott, CA (1999). Clinical characteristics of major depression that predict risk of depression in relatives. Archives of General Psychiatry 56, 322327.
Lake, RI, Eaves, LJ, Maes, HH, Heath, AC, Martin, NG (2000). Further evidence against the environmental transmission of individual differences in neuroticism from a collaborative study of 45,850 twins and relatives on two continents. Behavior Genetics 30, 223233.
Lovejoy, MC, Graczyk, PA, O'Hare, E, Neuman, G (2000). Maternal depression and parenting behavior: a meta-analytic review. Clinical Psychology Review 20, 561592.
Maes, HHM, Neale, MC, Kendler, KS, Hewitt, JK, Silberg, JL, Foley, DL, Meyer, JM, Rutter, M, Simonoff, E, Pickles, A, Eaves, LJ (1998). Assortative mating for major psychiatric diagnoses in two population-based samples. Psychological Medicine 28, 13891401.
Plomin, R, DeFries, JC, McClearn, Ge, McGuffin, P (2001). Behavior Genetics, 4th edn. Worth Publishers: New York.
Rhee, SH, Waldman, ID (2002). Genetic and environmental influences on antisocial behavior: a meta-analysis of twin and adoption studies. Psychological Bulletin 128, 490529.
Rice, F, Harold, GT, Thapar, A (2002). The genetic aetiology of childhood depression: a review. Journal of Child Psychology and Psychiatry 43, 6579.
Rice, F, Harold, GT, Thapar, A (2005). The link between depression in mothers and offspring: an extended twin analysis. Behavior Genetics 35, 565577.
Rutter, M (2007). Proceeding from observed correlation to causal inference: the use of natural experiments. Perspectives on Psychological Science 2, 377395.
Rutter, M, Pickles, A, Murray, R, Eaves, LJ (2001). Testing hypotheses on specific environmental causal effects on behavior. Psychological Bulletin 127, 291324.
Rutter, M, Silberg, J, O'Connor, T, Simonoff, E (1999). Genetics and child psychiatry: I. Advances in quantitative and molecular genetics. Journal of Child Psychology and Psychiatry 40, 318.
Shadish, WR, Cook, TD, Campbell, DT (2002). Experimental and Quasi-Experimental Designs for Generalized Causal Inference. Houghton Mifflin: New York.
Silberg, JL, Maes, H, Eaves, LJ (2010). Genetic and environmental influences on the transmission of parental depression to children's depression and conduct disturbance: an extended Children of Twins study. Journal of Child Psychology and Psychiatry 51, 734744.
Slutske, WS, D'Onofrio, BM, Turkheimer, E, Emery, RE, Harden, KP, Heath, AC, Martin, NG (2008). Searching for an environmental effect of parental alcoholism on offspring alcohol use disorder: a genetically informed study of children of alcoholics. Journal of Abnormal Psychology 117, 534551.
Slutske, WS, Heath, AC, Dinwiddie, SH, Madden, PA, Bucholz, KK, Dunne, MP, Statham, DJ, Martin, NG (1997). Modeling genetic and environmental influences in the etiology of conduct disorder: a study of 2,682 adult twin pairs. Journal of Abnormal Psychology 106, 266279.
Sullivan, P, Neale, M, Kendler, K (2000). Genetic epidemiology of major depression: review and meta-analysis. American Journal Psychiatry 157, 15521562.
Tully, E, Iacono, W, McGue, M (2008). An adoption study of parental depression as an environmental liability for adolescent depression and childhood disruptive disorders. American Journal of Psychiatry 165, 11481154.
von Knorring, AL, Cloninger, CR, Bohman, M, Sigvardsson, S (1983). An adoption study of depressive disorders and substance abuse. Archives of General Psychiatry 40, 943950.
Wender, PH, Kety, SS, Rosenthal, D, Schulsinger, F, Ortman, J, Lunde, I (1986). Psychiatric disorders in the biological and adoptive families of adopted individuals with affective disorders. Archives of General Psychiatry 43, 923929.

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