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Non-pharmacological interventions for adult ADHD: a systematic review

Published online by Cambridge University Press:  10 February 2020

Victoria Nimmo-Smith*
Affiliation:
Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK Avon & Wiltshire Partnership NHS Mental Health Trust, Bristol, UK
Andrew Merwood
Affiliation:
Portsmouth Hospitals NHS Trust, Queen Alexandra Hospital, Portsmouth, UK
Dietmar Hank
Affiliation:
Avon & Wiltshire Partnership NHS Mental Health Trust, Bristol, UK
Janet Brandling
Affiliation:
University of the West of England, Bristol, UK
Rosemary Greenwood
Affiliation:
Research and Innovation, University Hospitals Bristol NHS Foundation Trust, Bristol, UK
Lara Skinner
Affiliation:
Avon & Wiltshire Partnership NHS Mental Health Trust, Bristol, UK
Sarah Law
Affiliation:
Avon & Wiltshire Partnership NHS Mental Health Trust, Bristol, UK
Viran Patel
Affiliation:
The Wellbeing Partnership CIC, Bristol, UK
Dheeraj Rai
Affiliation:
Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK Avon & Wiltshire Partnership NHS Mental Health Trust, Bristol, UK
*
Author for correspondence: Victoria Nimmo-Smith, E-mail: victoria.nimmo-smith@bristol.ac.uk

Abstract

Background

Attention-deficit/hyperactivity disorder (ADHD) is a common developmental disorder, often persisting into adulthood. Whilst medication is first-line treatment for ADHD, there is a need for evidence-based non-pharmacological treatment options for adults with ADHD who are either still experiencing significant symptoms or for those who have made the informed choice not to start medication.

Methods

We systematically searched PsycINFO, MEDLINE (Ovid), EMBASE, CINAHL and CENTRAL for randomised controlled trials of non-pharmacological treatments for ADHD in adults. After screening of titles and abstracts, full text articles were reviewed, data extracted and bias assessed using a study proforma.

Results

There were 32 eligible studies with the largest number of studies assessing cognitive behavioural therapy (CBT). CBT consisted of either group, internet or individual therapy.

Conclusions

The majority found an improvement in ADHD symptoms with CBT treatment. Additionally, mindfulness and cognitive remediation have evidence as effective interventions for the core symptoms of ADHD and there is evidence for the use of group dialectical behavioural therapy and hypnotherapy. However, evidence for these is weaker due to small numbers of participants and limitations due to the lack of suitable control conditions, and a high risk of bias.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2020

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Footnotes

*

Victoria Nimmo Smith and Andrew Merwood are joint first authors.

References

Agnew-Blais, J. C., Polanczyk, G. V., Danese, A., Wertz, J., Moffitt, T. E., & Arseneault, L. (2016). Evaluation of the persistence, remission, and emergence of attention-deficit/hyperactivity disorder in young adulthood. JAMA Psychiatry, 73(7), 713720. doi: 10.1001/jamapsychiatry.2016.0465CrossRefGoogle ScholarPubMed
Beck, A. T., & Steer, R. A. (1990). Manual for the Beck anxiety inventory. J San Antonio, TX: Psychological Corporation.Google Scholar
Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Manual for the Beck depression inventory-II. San Antonio, TX: Psychological Corporation.Google Scholar
Brod, M., Johnston, J., Able, S., & Swindle, R. (2006). Validation of the adult attention-deficit/hyperactivity disorder quality-of-life scale (AAQoL): A disease-specific quality-of-life measure. Quality of Life Research, 15(1), 117129. doi: 10.1007/s11136-005-8325-zCrossRefGoogle ScholarPubMed
Castellanos, F. X., & Tannock, R. (2002). Neuroscience of attention-deficit/hyperactivity disorder: The search for endophenotypes. Nature Reviews Neuroscience, 3(8), 617628. doi: 10.1038/nrn896CrossRefGoogle ScholarPubMed
Cortese, S., Adamo, N., Del Giovane, C., Mohr-Jensen, C., Hayes, A. J., Carucci, S., & Cipriani, A. (2018). Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: A systematic review and network meta-analysis. The Lancet. Psychiatry, 5(9), 727738. doi: 10.1016/S2215-0366(18)30269-4CrossRefGoogle ScholarPubMed
Dalsgaard, S., Ostergaard, S. D., Leckman, J. F., Mortensen, P. B., & Pedersen, M. G. (2015). Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: A nationwide cohort study. Lancet, 385(9983), 21902196. doi: 10.1016/S0140-6736(14)61684-6CrossRefGoogle ScholarPubMed
Davidson, M. A. (2008). ADHD in adults: A review of the literature. Journal of Attention Disorders, 11(6), 628641. doi: 10.1177/1087054707310878CrossRefGoogle ScholarPubMed
Dittner, A. J., Hodsoll, J., Rimes, K. A., Russell, A. J., & Chalder, T. (2018). Cognitive-behavioural therapy for adult attention-deficit hyperactivity disorder: A proof of concept randomised controlled trial. Acta Psychiatrica Scandinavica, 137(2), 125137. doi: 10.1111/acps.12836CrossRefGoogle ScholarPubMed
Emilsson, B., Gudjonsson, G., Sigurdsson, J. F., Baldursson, G., Einarsson, E., Olafsdottir, H., & Young, S. (2011). Cognitive behaviour therapy in medication-treated adults with ADHD and persistent symptoms: A randomized controlled trial. BMC Psychiatry, 11, 116. doi: 10.1186/1471-244X-11-116CrossRefGoogle ScholarPubMed
Faraone, S. V., Biederman, J., & Mick, E. (2006). The age-dependent decline of attention deficit hyperactivity disorder: A meta-analysis of follow-up studies. Psychological Medicine, 36(2), 159165. doi: 10.1017/S003329170500471XCrossRefGoogle ScholarPubMed
Fleming, A. P., McMahon, R. J., Moran, L. R., Peterson, A. P., & Dreessen, A. (2015). Pilot randomized controlled trial of dialectical behavior therapy group skills training for ADHD among college students. Journal of Attention Disorders, 19(3), 260271. doi: 10.1177/1087054714535951CrossRefGoogle ScholarPubMed
Gajria, K., Lu, M., Sikirica, V., Greven, P., Zhong, Y., Qin, P., & Xie, J. (2014). Adherence, persistence, and medication discontinuation in patients with attention-deficit/hyperactivity disorder – a systematic literature review. Neuropsychiatric Disease and Treatment, 10, 1543. doi: 10.2147/NDT.S65721Google ScholarPubMed
Ginsberg, Y., Hirvikoski, T., & Lindefors, N. (2010). Attention Deficit Hyperactivity Disorder (ADHD) among longer-term prison inmates is a prevalent, persistent and disabling disorder. BMC Psychiatry, 10, 112. doi: 10.1186/1471-244X-10-112CrossRefGoogle ScholarPubMed
Gu, Y., Xu, G., & Zhu, Y. (2018). A randomized controlled trial of mindfulness-based cognitive therapy for college students with ADHD. Journal of Attention Disorders, 22(4), 388399. doi: 10.1177/1087054716686183CrossRefGoogle ScholarPubMed
Hayes, S. C., & Hofmann, S. G. (2017). The third wave of cognitive behavioral therapy and the rise of process-based care. World Psychiatry, 16(3), 245. doi: 10.1002/wps.20442CrossRefGoogle ScholarPubMed
Hepark, S., Janssen, L., de Vries, A., Schoenberg, P. L. A., Donders, R., Kan, C. C., & Speckens, A. E. M. (2019). The efficacy of adapted MBCT on core symptoms and executive functioning in adults with ADHD: A preliminary randomized controlled trial. Journal of Attention Disorders, 23(4), 351362. doi: 10.1177/1087054715613587CrossRefGoogle ScholarPubMed
Hesslinger, B., Philipsen, A., & Richter, H. (2004). Psychotherapie der ADHS im erwachsenenalter: Ein arbeitsbuch. Göttingen, Germany: Hogrefe Verlag GmbH & Co KG.Google Scholar
Higgins, J. P., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., … Cochrane Statistical Methods, G. (2011). The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ, 343, d5928. doi:10.1136/bmj.d5928.CrossRefGoogle ScholarPubMed
Hiltunen, S., Virta, M., Salakari, A., Antila, M., Chydenius, E., Kaski, M., … Partinen, M. (2014). Better long-term outcome for hypnotherapy than for CBT in adults with ADHD: Results of a six-month follow-up. Contemporary Hypnosis and Integrative Therapy, 30, 118134. Retrieved from https://www.researchgate.net/publication/264382321_Better_long-term_outcome_for_hypnotherapy_than_for_CBT_in_adults_with_ADHD_Results_of_a_six-month_follow-up.Google Scholar
Hirvikoski, T., Lindstrom, T., Carlsson, J., Waaler, E., Jokinen, J., & Bolte, S. (2017). Psychoeducational groups for adults with ADHD and their significant others (PEGASUS): A pragmatic multicenter and randomized controlled trial. European Psychiatry, 44, 141152. doi: 10.1016/j.eurpsy.2017.04.005CrossRefGoogle ScholarPubMed
Hirvikoski, T., Waaler, E., Alfredsson, J., Pihlgren, C., Holmstrom, A., Johnson, A., & Nordstrom, A. L. (2011). Reduced ADHD symptoms in adults with ADHD after structured skills training group: Results from a randomized controlled trial. Behaviour Research and Therapy, 49(3), 175185. doi: 10.1016/j.brat.2011.01.001CrossRefGoogle ScholarPubMed
Hodgson, K., Hutchinson, A. D., & Denson, L. (2014). Nonpharmacological treatments for ADHD: A meta-analytic review. Journal of Attention Disorders, 18(4), 275282. doi: 10.1177/1087054712444732CrossRefGoogle ScholarPubMed
Hofmann, S. G., Sawyer, A. T., Witt, A. A., & Oh, D. (2010). The effect of mindfulness-based therapy on anxiety and depression: A meta-analytic review. Journal of Consulting and Clinical Psychology, 78(2), 169. doi: 10.1037/a0018555CrossRefGoogle ScholarPubMed
Hoxhaj, E., Sadohara, C., Borel, P., D'Amelio, R., Sobanski, E., Muller, H., & Philipsen, A. (2018). Mindfulness vs psychoeducation in adult ADHD: A randomized controlled trial. European Archives of Psychiatry and Clinical Neuroscience, 268(4), 321335. doi: 10.1007/s00406-018-0868-4CrossRefGoogle ScholarPubMed
Janssen, L., Kan, C. C., Carpentier, P. J., Sizoo, B., Hepark, S., Schellekens, M. P. J., & Speckens, A. E. M. (2018). Mindfulness-based cognitive therapy v. treatment as usual in adults with ADHD: A multicentre, single-blind, randomised controlled trial (pg 1, 2018). Psychological Medicine, 48(11), 19201920. doi: 10.1017/S0033291718000776CrossRefGoogle Scholar
Ljung, T., Chen, Q., Lichtenstein, P., & Larsson, H. (2014). Common etiological factors of attention-deficit/hyperactivity disorder and suicidal behavior: A population-based study in Sweden. JAMA Psychiatry, 71(8), 958964. doi: 10.1001/jamapsychiatry.2014.363CrossRefGoogle ScholarPubMed
Lopez, P. L., Torrente, F. M., Ciapponi, A., Lischinsky, A. G., Cetkovich-Bakmas, M., Rojas, J. I., … Manes, F. F. (2018). Cognitive-behavioural interventions for attention deficit hyperactivity disorder (ADHD) in adults. Cochrane Database of Systematic Reviews, 3(CD010840), CD010840. doi:10.1002/14651858.CD010840.pub2.Google ScholarPubMed
Mawjee, K., Woltering, S., Lai, N., Gotlieb, H., Kronitz, R., & Tannock, R. (2017). Working memory training in ADHD: Controlling for engagement, motivation, and expectancy of improvement (pilot study). Journal of Attention Disorders, 21(11), 956968. doi: 10.1177/1087054714557356CrossRefGoogle Scholar
Mawjee, K., Woltering, S., & Tannock, R. (2015). Working memory training in post-secondary students with ADHD: A randomized controlled study. PLoS ONE, 10(9), e0137173. doi: 10.1371/journal.pone.0137173CrossRefGoogle ScholarPubMed
McCarthy, S., Wilton, L., Murray, M. L., Hodgkins, P., Asherson, P., & Wong, I. C. (2012). The epidemiology of pharmacologically treated attention deficit hyperactivity disorder (ADHD) in children, adolescents and adults in UK primary care. BMC Pediatrics, 12(1), 78. doi: 10.1186/1471-2431-12-78CrossRefGoogle ScholarPubMed
Mitchell, J. T., McIntyre, E. M., English, J. S., Dennis, M. F., Beckham, J. C., & Kollins, S. H. (2017). A pilot trial of mindfulness meditation training for ADHD in adulthood: Impact on core symptoms, executive functioning, and emotion dysregulation. Journal of Attention Disorders, 21(13), 11051120. doi: 10.1177/1087054713513328CrossRefGoogle ScholarPubMed
Moëll, B., Kollberg, L., Nasri, B., Lindefors, N., & Kaldo, V. (2015). Living SMART – A randomized controlled trial of a guided online course teaching adults with ADHD or sub-clinical ADHD to use smartphones to structure their everyday life. Internet Interventions, 2(1), 2431. Retrieved from https://doi.org/10.1016/j.invent.2014.11.004.CrossRefGoogle Scholar
NICE (2018). (NG87) Attention deficit hyperactivity disorder: Diagnosis and management. London: National Institute for Health and Care Excellence.Google Scholar
Pettersson, R., Sostrom, S., Edlund-Soderstrom, K., & Nilsson, K. W. (2017). Internet-based cognitive behavioral therapy for adults with ADHD in outpatient psychiatric care: A randomized trial. Journal of Attention Disorders, 21(6), 508521. doi: 10.1177/1087054714539998CrossRefGoogle Scholar
Philipsen, A., Jans, T., Graf, E., Matthies, S., Borel, P., Colla, M., … Psychotherapy in Adult, A. S. C. (2015). Effects of group psychotherapy, individual counseling, methylphenidate, and placebo in the treatment of adult attention-deficit/hyperactivity disorder: A randomized clinical trial. JAMA Psychiatry, 72(12), 11991210. doi:10.1001/jamapsychiatry.2015.2146.CrossRefGoogle ScholarPubMed
Safren, S. A., Otto, M. W., Sprich, S., Winett, C. L., Wilens, T. E., & Biederman, J. (2005). Cognitive-behavioral therapy for ADHD in medication-treated adults with continued symptoms. Behaviour Research and Therapy, 43(7), 831842. doi: 10.1016/j.brat.2004.07.001CrossRefGoogle ScholarPubMed
Safren, S. A., Sprich, S., Mimiaga, M. J., Surman, C., Knouse, L., Groves, M., & Otto, M. W. (2010). Cognitive behavioral therapy vs relaxation with educational support for medication-treated adults with ADHD and persistent symptoms: A randomized controlled trial. JAMA, 304(8), 875880. doi: 10.1001/jama.2010.1192CrossRefGoogle ScholarPubMed
Salomone, S., Fleming, G. R., Shanahan, J. M., Castorina, M., Bramham, J., O'Connell, R. G., & Robertson, I. H. (2015). The effects of a Self-Alert Training (SAT) program in adults with ADHD. Frontiers in Human Neuroscience, 9, 45. doi: 10.3389/fnhum.2015.00045CrossRefGoogle ScholarPubMed
Scheithauer, M. C., & Kelley, M. L. (2017). Self-monitoring by college students with ADHD: The impact on academic performance. Journal of Attention Disorders, 21(12), 10301039. doi: 10.1177/1087054714553050CrossRefGoogle ScholarPubMed
Schoenberg, P. L., Hepark, S., Kan, C. C., Barendregt, H. P., Buitelaar, J. K., & Speckens, A. E. (2014). Effects of mindfulness-based cognitive therapy on neurophysiological correlates of performance monitoring in adult attention-deficit/hyperactivity disorder. Clinical Neurophysiology, 125(7), 14071416. doi: 10.1016/j.clinph.2013.11.031CrossRefGoogle ScholarPubMed
Schonenberg, M., Wiedemann, E., Schneidt, A., Scheeff, J., Logemann, A., Keune, P. M., & Hautzinger, M. (2017). Neurofeedback, sham neurofeedback, and cognitive-behavioural group therapy in adults with attention-deficit hyperactivity disorder: A triple-blind, randomised, controlled trial. The Lancet. Psychiatry, 4(9), 673684. doi: 10.1016/S2215-0366(17)30291-2CrossRefGoogle ScholarPubMed
Shaw-Zirt, B., Popali-Lehane, L., Chaplin, W., & Bergman, A. (2005). Adjustment, social skills, and self-esteem in college students with symptoms of ADHD. Journal of Attention Disorders, 8(3), 109120. doi: 10.1177/1087054705277775CrossRefGoogle ScholarPubMed
Solanto, M. V., Marks, D. J., Wasserstein, J., Mitchell, K., Abikoff, H., Alvir, J. M., & Kofman, M. D. (2010). Efficacy of meta-cognitive therapy for adult ADHD. American Journal of Psychiatry, 167(8), 958968. doi: 10.1176/appi.ajp.2009.09081123CrossRefGoogle ScholarPubMed
Solanto, M. V., Surman, C. B., & Alvir, J. M. J. (2018). The efficacy of cognitive–behavioral therapy for older adults with ADHD: A randomized controlled trial. ADHD Attention Deficit and Hyperactivity Disorders, 10(3), 223235. doi: 10.1007/s12402-018-0253-1CrossRefGoogle ScholarPubMed
Spencer, T. J., Faraone, S. V., Tarko, L., McDermott, K., & Biederman, J. (2014). Attention-deficit/hyperactivity disorder and adverse health outcomes in adults. Journal of Nervous and Mental Disease, 202(10), 725731. doi: 10.1097/NMD.0000000000000191CrossRefGoogle ScholarPubMed
Stern, A., Malik, E., Pollak, Y., Bonne, O., & Maeir, A. (2016). The efficacy of computerized cognitive training in adults with ADHD: A randomized controlled trial. Journal of Attention Disorders, 20(12), 9911003. doi: 10.1177/1087054714529815CrossRefGoogle ScholarPubMed
Stevenson, C. S., Stevenson, R. J., & Whitmont, S. (2003). A self-directed psychosocial intervention with minimal therapist contact for adults with attention deficit hyperactivity disorder. Clinical Psychology & Psychotherapy, 10(2), 93101. Retrieved from https://doi.org/10.1002/cpp.356.CrossRefGoogle Scholar
Stevenson, C. S., Whitmont, S., Bornholt, L., Livesey, D., & Stevenson, R. J. (2002). A cognitive remediation programme for adults with attention deficit hyperactivity disorder. Australian and New Zealand Journal of Psychiatry, 36(5), 610616. doi: 10.1046/j.1440-1614.2002.01052.xCrossRefGoogle ScholarPubMed
Vidal, R., Bosch, R., Nogueira, M., Gomez-Barros, N., Valero, S., Palomar, G., & Ramos-Quiroga, J. A. (2013). Psychoeducation for adults with attention deficit hyperactivity disorder vs. Cognitive behavioral group therapy: A randomized controlled pilot study. Journal of Nervous and Mental Disease, 201(10), 894900. doi: 10.1097/NMD.0b013e3182a5c2c5Google ScholarPubMed
Virta, M., Salakari, A., Antila, M., Chydenius, E., Partinen, M., Kaski, M., & Iivanainen, M. (2010a). Hypnotherapy for adults with attention deficit hyperactivity disorder: A randomized controlled study. Contemporary Hypnosis, 27, 518. Retrieved from https://www.researchgate.net/publication/264382233_Hypnotherapy_for_adults_with_attention_deficit_hyperactivity_disorder_a_randomized_controlled_study.Google Scholar
Virta, M., Salakari, A., Antila, M., Chydenius, E., Partinen, M., Kaski, M., & Iivanainen, M. (2010b). Short cognitive behavioral therapy and cognitive training for adults with ADHD – a randomized controlled pilot study. Neuropsychiatric Disease and Treatment, 6, 443. doi: 10.2147/ndt.s11743CrossRefGoogle Scholar
Young, S., Emilsson, B., Sigurdsson, J. F., Khondoker, M., Philipp-Wiegmann, F., Baldursson, G., & Gudjonsson, G. (2017). A randomized controlled trial reporting functional outcomes of cognitive-behavioural therapy in medication-treated adults with ADHD and comorbid psychopathology. European Archives of Psychiatry and Clinical Neuroscience, 267(3), 267276. doi: 10.1007/s00406-016-0735-0CrossRefGoogle ScholarPubMed
Young, S., Khondoker, M., Emilsson, B., Sigurdsson, J., Philipp-Wiegmann, F., Baldursson, G., & Gudjonsson, G. (2015). Cognitive-behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: A randomized controlled trial using multi-level analysis. Psychological Medicine, 45(13), 27932804. doi: 10.1017/S0033291715000756CrossRefGoogle ScholarPubMed
Young, S., & Ross, R. (2007). R&R2 for youths and adults with mental health problems: A prosocial competence training program. Ottawa, Canada: Cognitive Centre of Canada.Google Scholar
Zetterqvist, J., Asherson, P., Halldner, L., Långström, N., & Larsson, H. (2013). Stimulant and non-stimulant attention deficit/hyperactivity disorder drug use: Total population study of trends and discontinuation patterns 2006–2009. Acta Psychiatrica Scandinavica, 128(1), 7077. doi: 10.1111/acps.12004CrossRefGoogle ScholarPubMed
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