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Multicompartmental analysis of amino acids: II. Tryptophan in affective disorder

  • David M. Shaw (a1), Simon F. Tidmarsh (a1), Anthony L. Johnson (a1), Alexandros C. Michalakeas (a1), Graham J. Riley (a1), Richard Blazek (a1) and Antony F. Francis (a1)...

Synopsis

Two of the tryptophan pools in the body and their associated fluxes, as defined by multicompartmental analysis, were studied in patients with unipolar affective disorder, bipolar patients (manic) and control subjects. The 2 pools were tentatively associated with extra- and intracellular compartments. The investigations were performed fasting and may have been mildly stressful. Under these conditions the concentration of tryptophan in plasma and perhaps amounts in the extracellular space were reduced in unipolar depression, with intermediate values after recovery. Some model parameters were lower in females than males. The results in unipolar affective disorder were interpreted in terms of a previously presented hypothesis that this illness may result in an idiosyncratic response to stress in which patients are unable to maintain normal amounts of tryptophan in the body. In manic patients extracellular levels of tryptophan were unchanged but intracellular and total quantities of ‘freely available’ tryptophan may have been reduced.

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Corresponding author

1Address for correspondence: Dr D. M. Shaw, Biochemical Psychiatry Laboratory, Department of Psychological Medicine, Welsh National School of Medicine, Whitchurch Hospital, Cardiff CF4 7XB.

References

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Altschule, M. D., Ascoli, I. & Tillotson, K. J. (1949). Extracellular fluid and plasma volumes in depressed patients given electric shock therapy. Archives of Neurology and Psychiatry (Chicago) 62, 618623.
Blazek, R., Tidmarsh, S. F., Shaw, D. M. & Riley, G. J. (1978). In preparation.
Bridges, P. K., Bartlett, J. R., Sepping, P., Kantameneni, B. D. & Curzon, G. (1976). Precursors and metabolites of 5-hydroxytryptamine and dopamine in the ventricular cerebrospinal fluid of psychiatric patients. Psychological Medicine 6, 399405.
Coppen, A. & Shaw, D. M. (1963). Mineral metabolism in melancholia. British Medical Journal ii, 14391444.
Coppen, A., Shaw, D. M. & Farrell, J. P. (1963). Potentiation of the antidepressive effect of a monoamine oxidase inhibitor by tryptophan. Lancet i, 7981.
Coppen, A., Shaw, D. M., Malleson, A. & Costain, R. (1966). Mineral metabolism in mania. British Medical Journal i, 7175.
Dawson, J., Hullin, R. P. & Crocket, B. M. (1956). Metabolic variations in manic-depressive psychosis. Journal of Mental Science 102, 168177.
Greenwood, M., Lader, M., Kantameneni, B. D. & Curzon, G. (1978). The effect of mental arithmetic under stress on tryptophan disposition in psychiatric patients. Submitted for publication.
Hullin, R. P., Bailey, A. D., McDonald, R., Dransfield, G. A. & Milne, H. B. (1967 a). Variations in body water during recovery from depression. British Journal of Psychiatry 113, 573583.
Hullin, R. P., Bailey, A. D., McDonald, R., Dransfield, G. A. & Milne, H. B. (1967 b). Body water variations in manic-depressive psychosis. British Journal of Psychiatry 113, 584592.
Landis, E. M. & Pappenheimer, J. R. (1963). Exchange of substances though the capillary walls. In Handbook of Physiology, Section 2. Circulation, vol. II (ed. Hamilton, W. F.), pp. 9611034. American Physiological Society: Washington.
Riley, G. J. & Shaw, D. M. (1976). Total and non-bound tryptophan in unipolar illness. Lancet ii, 1249.
Riley, G. J. & Shaw, D. M. (1978). In preparation.
Shaw, D. M., Johnson, A. L. & Short, R. (1972). Preliminary studies of the effects of lithium, imipramine and reserpine on the relative sizes of tryptophan pools and flow constants in rabbits. Mathematical Biosciences 15, 137151.
Shaw, D. M., Johnson, A. L., Tidmarsh, S. F., MacSweeney, D. A., Hewland, H. R. & Woolcock, N. E. (1975). Multi-compartmental analysis of amino acids. I. Preliminary data on concentrations, fluxes and flow constants of tryptophan in affective illness. Psychological Medicine 5, 206213.
Shaw, D. M., Riley, G. J., Tidmarsh, S. & Blazek, R. (1976). Unipolar affective illness. Lancet i, 363364.
Snedecor, G. W. & Cochran, W. G. (1967). Statistical Methods, 6th edn, pp. 472503. Iowa State University Press: Ames, Iowa.

Multicompartmental analysis of amino acids: II. Tryptophan in affective disorder

  • David M. Shaw (a1), Simon F. Tidmarsh (a1), Anthony L. Johnson (a1), Alexandros C. Michalakeas (a1), Graham J. Riley (a1), Richard Blazek (a1) and Antony F. Francis (a1)...

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