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Genetic co-morbidity between neuroticism, anxiety/depression and somatic distress in a population sample of adolescent and young adult twins

  • N. K. Hansell (a1), M. J. Wright (a1), S. E. Medland (a1), T. A. Davenport (a2), N. R. Wray (a1), N. G. Martin (a1) and I. B. Hickie (a2)...

Abstract

Background

Genetic studies in adults indicate that genes influencing the personality trait of neuroticism account for substantial genetic variance in anxiety and depression and in somatic health. Here, we examine for the first time the factors underlying the relationship between neuroticism and anxiety/depressive and somatic symptoms during adolescence.

Method

The Somatic and Psychological Health Report (SPHERE) assessed symptoms of anxiety/depression (PSYCH-14) and somatic distress (SOMA-10) in 2459 adolescent and young adult twins [1168 complete pairs (35.4% monozygotic, 53% female)] aged 12–25 years (mean=15.5±2.9). Differences between boys and girls across adolescence were explored for neuroticism, SPHERE-34, and the subscales PSYCH-14 and SOMA-10. Trivariate analyses partitioned sources of covariance in neuroticism, PSYCH-14 and SOMA-10.

Results

Girls scored higher than boys on both neuroticism and SPHERE, with SPHERE scores for girls increasing slightly over time, whereas scores for boys decreased or were unchanged. Neuroticism and SPHERE scores were strongly influenced by genetic factors [heritability (h2)=40–52%]. A common genetic source influenced neuroticism, PSYCH-14 and SOMA-10 (impacting PSYCH-14 more than SOMA-10). A further genetic source, independent of neuroticism, accounted for covariation specific to PSYCH-14 and SOMA-10. Environmental influences were largely specific to each measure.

Conclusions

In adolescence, genetic risk factors indexed by neuroticism contribute substantially to anxiety/depression and, to a lesser extent, perceived somatic health. Additional genetic covariation between anxiety/depressive and somatic symptoms, independent of neuroticism, had greatest influence on somatic distress, where it was equal in influence to the factor shared with neuroticism.

Copyright

Corresponding author

*Address for correspondence: Dr N. K. Hansell, Genetic Epidemiology, Queensland Institute of Medical Research, Post Office, Royal Brisbane Hospital, Queensland, Australia 4029. (Email: Narelle.Hansell@qimr.edu.au)

References

Hide All
APA (2000). Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association: Washington, DC.
Angold, A, Erkanli, A, Silberg, J, Eaves, L, Costello, EJ (2002). Depression scale scores in 8–17-year-olds: effects of age and gender. Journal of Child Psychology and Psychiatry 43, 10521063.
Bartels, M, van de Aa, N, van Beijsterveldt, CE, Middeldorp, CM, Boomsma, DI (2011). Adolescent self-report of emotional and behavioral problems: interactions of genetic factors with sex and age. Journal of the Canadian Academy of Child and Adolescent Psychiatry 20, 3552.
Birley, AJ, Gillespie, NA, Heath, AC, Sullivan, PF, Boomsma, DI, Martin, NG (2006). Heritability and nineteen-year stability of long and short EPQ-R Neuroticism scales. Personality and Individual Differences 40, 737747.
Boomsma, DI, Beem, AL, van den Berg, M, Dolan, CV, Koopmans, JR, Vink, JM, de Geus, EJ, Slagboom, PE (2000). Netherlands twin family study of anxious depression (NETSAD). Twin Research 3, 323334.
Costa, PT, McCrae, RR (1992). Revised NEO Personality Inventory (NEO PI-R) and NEO Five-Factor Inventory (NEO-FFI): Professional Manual. PAR: Lutz.
Dimsdale, JE, Dantzer, R (2011). A biological substrate for somatoform disorders: importance of pathophysiology. Psychosomatic Medicine 69, 850854.
Eysenck, HJ, Eysenck, SBG (1975). Manual for the Eysenck Personality Questionnaire (Adult and Junior). Digits: San Diego, CA.
Eysenck, SBG (1972). Junior Eysenck Personality Inventory. EdITS/Educational and Industrial Testing Service: San Diego, CA.
Fanous, A, Gardner, CO, Prescott, CA, Cancro, R, Kendler, KS (2002). Neuroticism, major depression and gender: a population-based twin study. Psychological Medicine 32, 719728.
Feigon, SA, Waldman, ID, Levy, F, Hay, DA (2001). Genetic and environmental influences on separation anxiety disorder symptoms and their moderation by age and sex. Behavior Genetics 31, 403411.
Franic, S, Middeldorp, CM, Dolan, CV, Ligthart, L, Boomsma, DI (2010). Childhood and adolescent anxiety and depression: beyond heritability. Journal of the American Academy of Child & Adolescent Psychiatry 49, 820829.
Freeman, MF, Tukey, JW (1950). Transformations related to the angular scale and the square root. Annals of Mathematical Statistics 21, 607611.
Frokjaer, VG, Vinberg, M, Erritzoe, D, Baare, W, Holst, KK, Mortensen, EL, Arfan, H, Madsen, J, Jernigan, TL, Kessing, LV, Knudsen, GM (2010). Familial risk for mood disorder and the personality risk factor, neuroticism, interact in their association with frontolimbic serotonin 2A receptor binding. Neuropsychopharmacology 35, 11291137.
Gillespie, N, Kirk, KM, Heath, AC, Martin, NG, Hickie, I (1999). Somatic distress as a distinct psychological dimension. Social Psychiatry and Psychiatric Epidemiology 34, 451458.
Gillespie, NA, Evans, DE, Wright, MM, Martin, NG (2004). Genetic simplex modeling of Eysenck's dimensions of personality in a sample of young Australian twins. Twin Research 7, 637648.
Gillespie, NA, Zhu, G, Heath, AC, Hickie, IB, Martin, NG (2000). The genetic aetiology of somatic distress. Psychological Medicine 30, 10511061.
Goldberg, DA (1996). A dimensional model for common mental disorders. British Journal of Psychiatry 168, 4449.
Hamilton, BA, Naismith, SL, Scott, EM, Purcell, S, Hickie, IB (2011). Disability is already pronounced in young people with early stages of affective disorders: data from an early intervention service. Journal of Affective Disorders 131, 8491.
Happonen, M, Pulkkinen, L, Kaprio, J, van der Meere, J, Viken, RJ, Rose, RJ (2002). The heritability of depressive symptoms: multiple informants and multiple measures. Journal of Child Psychology and Psychiatry 43, 471479.
Hetrick, SE, Parker, AG, Hickie, IB, Purcell, R, Yung, AR, McGorry, PD (2008). Early identification and intervention in depressive disorders: towards a clinical staging model. Psychotherapy and Psychosomatics 77, 263270.
Hettema, JM, Neale, MC, Myers, JM, Prescott, CA, Kendler, KS (2006). A population-based twin study of the relationship between neuroticism and internalizing disorders. American Journal of Psychiatry 163, 857864.
Hettema, JM, Prescott, CA, Kendler, KS (2004). Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticism. American Journal of Psychiatry 161, 15811587.
Hickie, I, Bennett, B, Lloyd, A, Heath, A, Martin, N (1999 a). Complex genetic and environmental relationships between psychological distress, fatigue and immune functioning: a twin study. Psychological Medicine 29, 269277.
Hickie, I, Davenport, T, Wakefield, D, Vollmer-Conna, U, Cameron, B, Vernon, SD, Reeves, WC, Lloyd, A (2006). Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. British Medical Journal 333, 575.
Hickie, I, Hadzi-Pavlovic, D, Ricci, C (1997). Reviving the diagnosis of neurasthenia. Psychological Medicine 27, 989994.
Hickie, I, Kirk, K, Martin, N (1999 b). Unique genetic and environmental determinants of prolonged fatigue: a twin study. Psychological Medicine 29, 259268.
Hickie, I, Koschera, A, Hadzi-Pavlovic, D, Bennett, B, Lloyd, A (1999 c). The temporal stability and co-morbidity of prolonged fatigue: a longitudinal study in primary care. Psychological Medicine 29, 855861.
Hickie, I, Lloyd, A, Wakefield, D, Parker, G (1990). The psychiatric status of patients with the chronic fatigue syndrome. British Journal of Psychiatry 156, 534540.
Hickie, IB, Davenport, TA, Hadzi-Pavlovic, D, Koschera, A, Naismith, SL, Scott, EM, Wilhelm, KA (2001 a). Development of a simple screening tool for common mental disorders in general practice. Medical Journal of Australia 175, S10S24.
Hickie, IB, Davenport, TA, Scott, EM, Hadzi-Pavlovic, D, Naismith, SL, Koschera, A (2001 b). Unmet need for recognition of common mental disorders in Australian general practice. Medical Journal of Australia 175 (Suppl.) S18S24.
Hickie, IB, Rogers, NL (2011). Novel melatonin-based therapies: potential advances in the treatment of major depression. Lancet 378, 621631.
Kato, K, Sullivan, PF, Evengard, B, Pedersen, NL (2009). A population-based twin study of functional somatic syndromes. Psychological Medicine 39, 497505.
Kendler, KS, Gardner, CO, Gatz, M, Pederson, NL (2007). The sources of co-morbidity between major depression and generalized anxiety disorder in a Swedish national twin sample. Psychological Medicine 37, 453462.
Kendler, KS, Gardner, CO, Lichtenstein, P (2008). A developmental twin study of symptoms of anxiety and depression: evidence for genetic innovation and attenuation. Psychological Medicine 38, 15671575.
Kirk, KM, Hickie, IB, Martin, NG (1999). Fatigue as related to anxiety and depression in a community-based sample of twins aged over 50. Social Psychiatry and Psychiatric Epidemiology 34, 8590.
Kirmayer, LJ, Robbins, JM, Paris, J (1994). Somatoform disorders: personality and the social matrix of somatic distress. Journal of Abnormal Psychology 103, 125136.
Kotov, R, Gamez, W, Schmidt, F, Watson, D (2010). Linking ‘big’ personality traits to anxiety, depressive, and substance use disorders: a meta-analysis. Psychological Bulletin 136, 768821.
Kraemer, HC (2007). DSM categories and dimensions in clinical and research contexts. International Journal of Methods in Psychiatric Research 16, S8–S15.
Krueger, RF, Chentsova-Dutton, YE, Markon, KE, Goldberg, D, Ormel, J (2003). A cross-cultural study of the structure of comorbidity among common psychopathological syndromes in the general health care setting. Journal of Abnormal Psychology 112, 437447.
Lamb, DJ, Middeldorp, CM, van Beijsterveldt, CEM, Bartels, M, van der Aa, N, Polderman, TJC, Boomsma, DI (2010). Heritability of anxious-depressive and withdrawn behavior: age-related changes during adolescence. Journal of American Academy of Child & Adolescent Psychiatry 49, 248255.
McCrae, RR, Costa, PT (2004). A contemplated revision of the NEO Five-Factor Inventory. Personality and Individual Differences 36, 587596.
McCrae, RR, Costa, PT (2010). NEO Inventories for the NEO Personality Inventory-3 (NEO-PI-3), NEO Five-Factor Inventory-3 (NEO-FFI-3), NEO Personality Inventory-Revised (NEO PI-R): Professional Manual. PAR: Lutz, FL.
McCrae, RR, Costa, PT Jr., Terracciano, A, Parker, WD, Mills, CJ, de Fruyt, F, Mervielde, I (2002). Personality trait development from age 12 to age 18: longitudinal, cross-sectional, and cross-cultural analyses. Journal of Personality and Social Psychology 83, 14561468.
McGorry, P (2011). Transition to adulthood: the critical period for pre-emptive, disease-modifying care for schizophrenia and related disorders. Schizophrenia Bulletin 37, 524530.
McGorry, PD, Purcell, R, Goldstone, S, Amminger, GP (2011). Age of onset and timing of treatment for mental and substance use disorders: implications for preventive intervention strategies and models of care. Current Opinion in Psychiatry 24, 301306.
McGregor, B, Pfitzner, J, Zhu, G, Grace, M, Eldridge, A, Pearson, J, Mayne, C, Aitken, JF, Green, AC, Martin, NG (1999). Genetic and environmental contributions to size, color, shape, and other characteristics of melanocytic naevi in a sample of adolescent twins. Genetic Epidemiology 16, 4053.
Martin, NG, Jardine, R, Andrews, G, Heath, AC (1988). Anxiety disorders and neuroticism: are there genetic factors specific to panic. Acta Psychiatrica Scandinavica 77, 698706.
Medland, SE, Nyholt, DR, Painter, JN, McEvoy, BP, McRae, AF, Zhu, G, Gordon, SD, Ferreira, MA, Wright, MJ, Henders, AK, Campbell, MJ, Duffy, DL, Hansell, NK, Macgregor, S, Slutske, WS, Heath, AC, Montgomery, GW, Martin, NG (2009). Common variants in the trichohyalin gene are associated with straight hair in Europeans. American Journal of Human Genetics 85, 750755.
Merikangas, KR, He, JP, Burstein, M, Swanson, SA, Avenevoli, S, Cui, L, Benjet, C, Georgiades, K, Swendsen, J (2010). Lifetime prevalence of mental disorders in US adolescents: results from the National Comorbidity Survey Replication – Adolescent Supplement (NCS-A). Journal of the American Academy of Child and Adolescent Psychiatry 49, 980989.
Neale, MC, Boker, SM, Xie, G, Maes, HH (2003). Mx: Statistical Modeling. Department of Psychiatry: Richmond, VA.
Neale, MC, Cardon, LR (1992). Methodology for Genetic Studies of Twins and Families. Kluwer Academic Publishers: Dordrecht.
Neale, MC, Eaves, LJ, Kendler, KS (1994). The power of the classical twin study to resolve variation in threshold traits. Behavior Genetics 24, 239258.
Parker, JD, Taylor, GJ, Bagby, RM (1989). The alexithymia construct: relationship with sociodemographic variables and intelligence. Comprehensive Psychiatry 30, 434441.
Pennebaker, JW, Watson, D (1991). The psychology of somatic symptoms. In Current Concepts of Somatization (ed. Kirmayer, L. J. and Robbins, J. M.). American Psychiatric Press: Washington DC.
Raison, CL, Capuron, L, Miller, AH (2006). Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends in Immunology 27, 2431.
Rettew, DC, Vink, JM, Willemsen, G, Doyle, A, Hudziak, JJ, Boomsma, DI (2006). The genetic architecture of neuroticism in 3301 Dutch adolescent twins as a function of age and sex: a study from the Dutch Twin Register. Twin Research and Human Genetics 9, 2429.
Rice, F, Harold, GT, Thapar, A (2002). Assessing the effects of age, sex, and shared environment on the genetic aetiology of depression in childhood and adolescence. Journal of Child Psycholgy & Psychiatry 43, 10391051.
Rief, W, Hennings, A, Riemer, S, Euteneuer, F (2010). Psychobiological differences between depression and somatization. Journal of Psychosomatic Research 68, 496502.
Rief, W, Pilger, F, Ihle, D, Verlerk, R, Scharpe, S, Maes, M (2004). Psychobiological aspects of somatoform disorders: contributions of monoaminergic transmitter systems. Neuropsychobiology 49, 2429.
Robbins, JM, Kirmayer, LJ (1991). Cognitive and social factors in somatization. In Current Concepts of Somatization: Research and Clinical Perspectives (ed. Kirmayer, L. J. and Robbins, J. M.), pp. 107141. American Psychiatric Press: Washington DC.
Ruscio, J, Ruscio, AM (2000). Informing the continuity controversy: a taxometric analysis of depression. Journal of Abnormal Psychology 109, 473487.
Sakashita, C, Slade, T, Andrews, G (2007). Empirical investigation of two assumptions in the diagnosis of DSM-IV major depressive episode. Australian and New Zealand Journal of Psychiatry 41, 1723.
Slade, T, Andrews, G (2005). Latent structure of depression in a community sample: a taxometric analysis. Psychological Medicine 35, 489497.
Sund, AM, Larsson, B, Wichstrom, L (2001). Depressive symptoms among young Norwegian adolescents as measured by The Mood and Feelings Questionnaire (MFQ). European Child & Adolescent Psychiatry 10, 222229.
Sutin, AR, Terracciano, A, Deiana, B, Naitza, S, Ferrucci, L, Uda, M, Schlessinger, D, Costa, PT Jr. (2010). High neuroticism and low conscientiousness are associated with interleukin-6. Psychological Medicine 40, 14851493.
Terracciano, A, Costa, Jr. PT, McCrae, RR (2006). Personality plasticity after age 30. Personality and Social Psychology Bulletin 32, 999–1009.
Ustun, TB, Sartorius, N (eds.) (1995). Mental Illness in General Health Care: An International Study. John Wiley & Sons: London.
Vaccarino, AL, Sills, TL, Evans, KR, Kalali, AH (2009). Multiple pain complaints in patients with major depressive disorder. Psychosomatic Medicine 71, 159162.
Vallejo, MA, Jordan, CM, Diaz, MI, Comeche, MI, Ortega, J (2007). Psychological assessment via the internet: a reliability and validity study of online (vs paper-and-pencil) versions of the General Health Questionnaire-28 (GHQ-28) and the Symptoms Check-List-90-Revised (SCL-90-R). Journal of Medical Internet Research 9, e2.
van der Linden, G, Chalder, T, Hickie, I, Koschera, A, Sham, P, Wessely, S (1999). Fatigue and psychiatric disorder: different or the same? Psychological Medicine 29, 863868.
Vassend, O, Roysamb, E, Nielsen, CS (2011). Neuroticism and self-reported somatic health: a twin study. Psychology & Health. Published online: 14 June 2011. doi:10.1080/08870446.2010.540665.
Vercoulen, JH, Swanink, CM, Zitman, FG, Vreden, SG, Hoofs, MP, Fennis, JF, Galama, JM, van der Meer, JW, Bleijenberg, G (1996). Randomised, double-blind, placebo-controlled study of fluoxetine in chronic fatigue syndrome. Lancet 347, 858861.
Vollmer-Conna, U, Fazou, C, Cameron, B, Li, H, Brennan, C, Luck, L, Davenport, T, Wakefield, D, Hickie, I, Lloyd, A (2004). Production of pro-inflammatory cytokines correlates with the symptoms of acute sickness behaviour in humans. Psychological Medicine 34, 12891297.
Wijeratne, C, Hickie, I, Davenport, T (2006). Is there an independent somatic symptom dimension in older people? Journal of Psychosomatic Research 61, 197204.
Wray, NR, Birley, AJ, Sullivan, PF, Visscher, PM, Martin, NG (2007). Genetic and phenotypic stability of measures of neuroticism over 22 years. Twin Research and Human Genetics 10, 695702.
Wright, MJ, Martin, NG (2004). The Brisbane Adolescent Twin Study: outline of study methods and research projects. Australian Journal of Psychology 56, 6578.

Keywords

Genetic co-morbidity between neuroticism, anxiety/depression and somatic distress in a population sample of adolescent and young adult twins

  • N. K. Hansell (a1), M. J. Wright (a1), S. E. Medland (a1), T. A. Davenport (a2), N. R. Wray (a1), N. G. Martin (a1) and I. B. Hickie (a2)...

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