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Functional neuroimaging of resilience to trauma: convergent evidence and challenges for future research

Published online by Cambridge University Press:  02 June 2023

Agnes Norbury Open the ORCID record for Agnes Norbury [Opens in a new window] ,
Saren H. Seeley ,
M. Mercedes Perez-Rodriguez  and
Adriana Feder Open the ORCID record for Adriana Feder [Opens in a new window]
Agnes Norbury
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA Queen Square Institute of Neurology and Mental Health Neuroscience Department, Applied Computational Psychiatry Lab, Max Planck Centre for Computational Psychiatry and Ageing Research, University College London, London, UK
Saren H. Seeley
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
M. Mercedes Perez-Rodriguez
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Adriana Feder*
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
*
Corresponding author: Adriana Feder; Email: adriana.feder@mssm.edu
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Abstract

Resilience is broadly defined as the ability to adapt successfully following stressful life events. Here, we review functional MRI studies that investigated key psychological factors that have been consistently linked to resilience to severe adversity and trauma exposure. These domains include emotion regulation (including cognitive reappraisal), reward responsivity, and cognitive control. Further, we briefly review functional imaging evidence related to emerging areas of study that may potentially facilitate resilience: namely social cognition, active coping, and successful fear extinction. Finally, we also touch upon ongoing issues in neuroimaging study design that will need to be addressed to enable us to harness insight from such studies to improve treatments for – or, ideally, guard against the development of – debilitating post-traumatic stress syndromes.

Keywords

resiliencetrauma exposurefMRIneuroimaging
Type
Review Article
Information
Psychological Medicine , Volume 53 , Issue 8 , June 2023 , pp. 3293 - 3305
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Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press

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Footnotes

*

Shared first authorship; These authors contributed equally to this work.

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