Hostname: page-component-848d4c4894-tn8tq Total loading time: 0 Render date: 2024-07-07T01:05:17.903Z Has data issue: false hasContentIssue false

Does prostacyclin prevent cognitive deficits after open heart surgery?

Published online by Cambridge University Press:  09 July 2009

Elizabeth Pears*
Affiliation:
Department of Psychiatry, University of Manchester, and Manchester Royal Infirmary, Manchester
Richard Bowman
Affiliation:
Department of Psychiatry, University of Manchester, and Manchester Royal Infirmary, Manchester
John Kincey
Affiliation:
Department of Psychiatry, University of Manchester, and Manchester Royal Infirmary, Manchester
Ramji Gautam
Affiliation:
Department of Psychiatry, University of Manchester, and Manchester Royal Infirmary, Manchester
*
1Address for correspondence: Ms Elizabeth Pears Department of Psychiatry, Stopford Building, University of Manchester, Manchester M13 9PT.

Synopsis

Two groups of open heart surgery patients, one receiving prostacyclin and one placebo, were assessed one week pre-operatively and 3 months post-operatively, using a battery of clinical tests measuring a variety of cognitive functions. No significant differences between the groups were detected, apart from a visual retention deficit at 3 months in the prostacyclin group. The results cast doubt on previous findings suggesting that prostacyclin reduces cognitive deficits following open heart surgery.

Type
Brief Communication
Copyright
Copyright © Cambridge University Press 1984

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bennett, J. G., Longmore, D. B. & O'Grady, J. (1981). Use of prostacyclin in cardiopulmonary bypass in man. In Clinical Pharmacology of Prostacyclin (ed. Lewis, P. J. and O'Grady, J.), pp. 201208. Raven Press: New York.Google Scholar
Blachly, P. H. & Starr, A. (1964). Post-cardiotomy delirium. American Journal of Psychiatry 121, 371375.CrossRefGoogle Scholar
Brierley, J. B. (1963). Neuropathological findings in patients dying after open heart surgery. Thorax 18, 291304.CrossRefGoogle ScholarPubMed
Bunting, S., O'Grady, J., Fabiani, J. N., Terrier, E., Moncada, S., Vane, J. R. & Dubost, C. (1981). Cardiopulmonary bypass in man: effects of prostacyclin. In Clinical Pharmacology of Prostacyclin (ed. Lewis, P. J. and O'Grady, J.), pp. 181193.Google Scholar
Egerton, N. & Kay, J. H. (1964). Psychological disturbances associated with open heart surgery. British Journal of Psychiatry 110, 433439.CrossRefGoogle ScholarPubMed
Gilberstadt, H. & Sako, Y. (1967). Intellectual and personality changes following open heart surgery. Archives of General Psychiatry 16, 210214.CrossRefGoogle ScholarPubMed
Gilman, S. (1965). Cerebral disorders after open heart operations. New England Journal of Medicine 272, 489498.CrossRefGoogle ScholarPubMed
Layne, O. L. & Yudofsky, S. C. (1971). Post-operative psychosis in cardiotomy patients. New England Journal of Medicine 284, 518520.CrossRefGoogle Scholar
Lee, W. H., Brady, M. P., Rowe, J. M. & Miller, W. C. (1971). Effects of extracorporeal circulation upon behaviour, personality, and brain function. Annals of Surgery 173, 10131023.CrossRefGoogle ScholarPubMed
Longmore, D. B., Bennett, J. G., Hoyle, P. M., Smith, M. A., Gregory, A., Osivano, T. & Jones, W. A. (1981). Prostacyclin administration during cardiopulmonary bypass in man. Lancet ii, 800804.CrossRefGoogle Scholar
O'Grady, J. (1980). Prostacyclin. In Recent Advances in Clinical Pharmacology, Vol. 2 (ed. Turner, P. and Shand, D.), pp. 113128. Churchill Livingstone: Edinburgh.Google Scholar
Pokar, H., Reuter, H., Kalmar, P. & Tilsner, V. (1981). Anwendung von Prostazydlin während des extrakorporalen Kreislaufs bei Operationen am offenen Herzen. Blut 42, 115.Google Scholar
Silverstein, A., Jacobson, E., Kreel, I. & Krieger, H. P. (1960). Effects on the brain of extracorporeal circulation in open heart surgery. Neurology 10, 987992.CrossRefGoogle Scholar
Sotaniemi, K. A., Juolasmaa, A. & Hokkanen, E. T. (1981). Neuropsychological outcome after open heart surgery. Archives of Neurology 38, 28.CrossRefGoogle ScholarPubMed
Walker, I. D., Davidson, J. F., Faichney, A., Wheatley, D. & Davidson, K. (1981). Prostacyclin in cardiopulmonary bypass surgery. In Clinical Pharmacology of Prostacyclin (ed. Lewis, P. J. and O'Grady, J.), pp. 195199. Raven Press: New York.Google Scholar