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Disrupted dynamic network reconfiguration of the executive and reward networks in internet gaming disorder

Published online by Cambridge University Press:  25 August 2022

Min Wang ,
Hui Zheng ,
Weiran Zhou ,
Bo Yang ,
Lingxiao Wang ,
Shuaiyu Chen  and
Guang-Heng Dong Open the ORCID record for Guang-Heng Dong [Opens in a new window]
Min Wang
Affiliation:
Center for Cognition and Brain Disorders, School of Clinical Medicine, Hangzhou Normal University, Hangzhou, Zhejiang Province, PR China The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, PR China
Hui Zheng
Affiliation:
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China
Weiran Zhou
Affiliation:
Center for Cognition and Brain Disorders, School of Clinical Medicine, Hangzhou Normal University, Hangzhou, Zhejiang Province, PR China
Bo Yang
Affiliation:
Center for Cognition and Brain Disorders, School of Clinical Medicine, Hangzhou Normal University, Hangzhou, Zhejiang Province, PR China
Lingxiao Wang
Affiliation:
Center for Cognition and Brain Disorders, School of Clinical Medicine, Hangzhou Normal University, Hangzhou, Zhejiang Province, PR China The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, PR China
Shuaiyu Chen
Affiliation:
Center for Cognition and Brain Disorders, School of Clinical Medicine, Hangzhou Normal University, Hangzhou, Zhejiang Province, PR China The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, PR China
Guang-Heng Dong*
Affiliation:
Center for Cognition and Brain Disorders, School of Clinical Medicine, Hangzhou Normal University, Hangzhou, Zhejiang Province, PR China The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, PR China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang Province, PR China
*
Author for correspondence: Guang-Heng Dong, E-mail: dongguangheng@hznu.edu.cn
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Abstract

Background

Studies have shown that people with internet gaming disorder (IGD) exhibit impaired executive control of gaming cravings; however, the neural mechanisms underlying this process remain unknown. In addition, these conclusions were based on the hypothesis that brain networks are temporally static, neglecting dynamic changes in cognitive processes.

Methods

Resting-state fMRI data were collected from 402 subjects [162 subjects with IGD and 240 recreational game users (RGUs)]. The community structure (recruitment and integration) of the executive control network (ECN) and the basal ganglia network (BGN), which represents the reward network, of patients with IGD and RGUs were compared. Mediation effects among the different networks were analyzed.

Results

Compared to RGUs, subjects with IGD had a lower recruitment coefficient within the right ECN. Further analysis showed that only male subjects had a lower recruitment coefficient. Mediation analysis showed that the integration coefficient of the right ECN mediated the relationship between the recruitment coefficients of both the right ECN and the BGN in RGUs.

Conclusions

Male subjects with IGD had a lower recruitment coefficient than RGUs, which impairing their impulse control. The mediation results suggest that top-down executive control of the ECN is absent in subjects with IGD. Together, these findings could explain why subjects with IGD exhibit impaired executive control of gaming cravings; these results have important therapeutic implications for developing effective interventions for IGD.

Keywords

Community structureexecutive controlinternet gaming disorderrecruitment
Type
Original Article
Information
Psychological Medicine , Volume 53 , Issue 12 , September 2023 , pp. 5478 - 5487
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

These authors contributed equally to this work.

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