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Dementia, deep white matter damage and hypertension: ‘Binswanger's disease’

Published online by Cambridge University Press:  09 July 2009

I. Janota
I. Janota*
Affiliation:
Department of Neutopathology, Institute of Psychiatry, London
*
1Address for correspondence: Dr I. Janota, Department of Neuropathology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF.
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Synopsis

The clinical and neuropathological features are reported of 7 patients with organic intellectual impairment or dementia, hypertension and ischaemic destruction predominantly of the deep white matter of the cerebral hemispheres resembling that seen in infarction. The white matter changes have been dismissed as rare in the past, usually under the name of Binswanger's disease or subcortical arteriosclerotic encephalopathy, and without much concern for hypertension. There are now indications that this sort of case may not be uncommon. It can be suspected in life on CT scans. The accuracy of assessment of the pathological substrate of organic dementia, and therefore the strategies of research and treatment, might well benefit from further clinicopathological studies.

Type
Research Article
Information
Psychological Medicine , Volume 11 , Issue 1 , February 1981 , pp. 39 - 48
Copyright
Copyright © Cambridge University Press 1981

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