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The cerebral cortical appearance in depressed subjects

  • R. J. Dolan (a1), S. P. Calloway (a1), P. F. Thacker (a1) and A. H. Mann (a1)

Synopsis

This paper describes a comparison of the cerebral cortical appearance of 101 patients with a history of clinical depression and 52 control subjects. An age-related increase in sulcal widening was evident in both groups. However, after controlling for age, the patients were found to differ from control subjects in two respects: they had a greater amount of sulcal widening, most noticeably in the frontal and temporal areas; and there was a positive correlation between increasing sulcal widening and increasing lateral ventricular size not found in the control subjects. Patients with a past history of treatment by electroconvulsive therapy showed more sulcal widening in the parietal and occipital areas than those not so treated.

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Corresponding author

1Address for correspondence: Dr R. J. Dolan, Department of Psychological Medicine, The National Hospital for Nervous Diseases, Queen Square, London WC1N 3BG.

References

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The cerebral cortical appearance in depressed subjects

  • R. J. Dolan (a1), S. P. Calloway (a1), P. F. Thacker (a1) and A. H. Mann (a1)

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