Skip to main content Accessibility help

The cerebral cortical appearance in depressed subjects

  • R. J. Dolan (a1), S. P. Calloway (a1), P. F. Thacker (a1) and A. H. Mann (a1)


This paper describes a comparison of the cerebral cortical appearance of 101 patients with a history of clinical depression and 52 control subjects. An age-related increase in sulcal widening was evident in both groups. However, after controlling for age, the patients were found to differ from control subjects in two respects: they had a greater amount of sulcal widening, most noticeably in the frontal and temporal areas; and there was a positive correlation between increasing sulcal widening and increasing lateral ventricular size not found in the control subjects. Patients with a past history of treatment by electroconvulsive therapy showed more sulcal widening in the parietal and occipital areas than those not so treated.


Corresponding author

1Address for correspondence: Dr R. J. Dolan, Department of Psychological Medicine, The National Hospital for Nervous Diseases, Queen Square, London WC1N 3BG.


Hide All
Andreasen, N. C., Smith, M. R., Jacoby, C. G., Dennert, J. W. & Olsen, S. A. (1982). Ventricular enlargement in schizophrenia: definition and prevalence. American Journal of Psychiatry 139, 292296.
Baker, R. S. & Nelder, S. A. (1978). The GLIM System. Release 3: Generalised Linear Interactive Modelling. Royal Statistical Society: London.
Calloway, S. P., Dolan, R. J., Jacoby, R. J. & Levy, R. (1981). ECT and cerebral atrophy. Acta Psychiatrica Scandinavica 64, 442445.
Dolan, R. J., Calloway, S. P. & Mann, A. H. (1985). Cerebral ventricular size in depressed subjects. Psychological Medicine 15, 873878.
Everitt, B. S. & Dunn, G. (1983). Advanced Methods of Data Exploration and Modelling. Heinemann Educational Books: London.
Golden, C. J., Moses, J. A. Jr, Zelazowski, R., Graber, B., Zatz, L. M., Horvath, T. B. & Berger, P. A. (1980). Cerebral ventricular size and neuropsychological impairment in young chronic schizophrenics: measurement by the standardised Luria-Nebraska Neuropsychological Battery. Archives of General Psychiatry 37, 619623.
Hull, H. C. & Nie, H. H. (1981). SPSS Update 7–9: New Procedures and Facilities for Releases 7–9. McGraw-Hill: New York.
Jacoby, R. J. & Levy, R. (1980). Computed tomography in the elderly: 3. Affective disorder. British Journal of Psychiatry 136, 270275.
Nasrallah, H. A., McCalley-Whitters, M. & Jacoby, C. G. (1982). Cerebral ventricular enlargement in young manic males: a controlled CT study. Journal of Affective Disorders 4, 1519.
Rieder, R., Mann, L. S., Weinberger, D. R., van Kammen, D. P. & Post, R. M. (1983). Computed tomographic scans in patients with schizophrenia, schizo-affective and bipolar affective disorder. Archives of General Psychiatry 40, 735739.
Ron, M. A. (1983). The Alcoholic Brain: CT Scan and Psychological Findings. Psychological Medicine. Monograph Supplement 3. Cambridge University Press: Cambridge.
Spitzer, R. L., Endicott, J. & Robins, E. (1978). Research diagnostic criteria. Rationale and reliability. Archives of General Psychiatry 35, 773782.
Tanaka, Y., Hazama, H., Fukuhara, T. & Tsutsui, T. (1982). Computerised tomography of the brain in manic-depressive patients – a controlled study. Folia Psychiatrica et Neurologica Japonica 36, 137144.
Turner, S. W., Toone, B. K. & Brett-Jones, J. R. (1986). Computerized tomographic scan changes in early schizophrenia – preliminary findings. Psychological Medicine 16, 219225.
Weinberger, D. R., Torrey, E. F., Neophytides, A. N. & Wyatt, R. J. (1979 a). Lateral cerebral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry 36, 735739.
Weinberger, D. R., Torrey, E. F., Neophytides, A. N. & Wyatt, R. J. (1979 b). Structural abnormalities in the cerebral cortex of chronic schizophrenia patients. Archives of General Psychiatry 36, 935939.

The cerebral cortical appearance in depressed subjects

  • R. J. Dolan (a1), S. P. Calloway (a1), P. F. Thacker (a1) and A. H. Mann (a1)


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed