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Brain network integration underpins differential susceptibility of adolescent anxiety

Published online by Cambridge University Press:  02 October 2023

Qingwen Ding ,
Jiahua Xu ,
Siya Peng ,
Jie Chen ,
Yu Luo ,
Xuebing Li ,
Ruilin Wu ,
Xinying Li  and
Shaozheng Qin
Qingwen Ding
Affiliation:
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Jiahua Xu
Affiliation:
Chinese Institute for Brain Research, Beijing, China Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London, UK
Siya Peng
Affiliation:
IDG/McGovern Institute for Brain Research, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China
Jie Chen
Affiliation:
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Yu Luo
Affiliation:
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Xuebing Li
Affiliation:
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Ruilin Wu
Affiliation:
Institute of Psychology, Beihang University, Beijing, China
Xinying Li*
Affiliation:
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Shaozheng Qin*
Affiliation:
Chinese Institute for Brain Research, Beijing, China IDG/McGovern Institute for Brain Research, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China
*
Corresponding authors: Xinying Li; Email: lixy@psych.ac.cn; Shaozheng Qin; szqin@bnu.edu.cn
Corresponding authors: Xinying Li; Email: lixy@psych.ac.cn; Shaozheng Qin; szqin@bnu.edu.cn
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Abstract

Background

Parenting is a common and potent environmental factor influencing adolescent anxiety. Yet, the underlying neurobiological susceptibility signatures remain elusive. Here, we used a longitudinal twin neuroimaging study to investigate the brain network integration and its heritable relation to underpin the neural differential susceptibility of adolescent anxiety to parenting environments.

Methods

216 twins from the Beijing Twin Study completed the parenting and anxiety assessments and fMRI scanning. We first identified the brain network integration involved in the influences of parenting at age 12 on anxiety symptoms at age 15. We then estimated to what extent heritable sensitive factors are responsible for the susceptibility of brain network integration.

Results

Consistent with the differential susceptibility theory, the results showed that hypo-connectivity within the central executive network amplified the impact of maternal hostility on anxiety symptoms. A high anti-correlation between the anterior salience and default mode networks played a similar modulatory role in the susceptibility of adolescent anxiety to paternal hostility. Genetic influences (21.18%) were observed for the connectivity pattern in the central executive network.

Conclusions

Brain network integration served as a promising neurobiological signature of the differential susceptibility to adolescent anxiety. Our findings deepen the understanding of the neural sensitivity in the developing brain and can inform early identification and personalized interventions for adolescents at risk of anxiety disorders.

Keywords

Adolescent anxietyneural susceptibilitybrain network
Type
Original Article
Information
Psychological Medicine , Volume 54 , Issue 1 , January 2024 , pp. 193 - 202
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Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press

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Footnotes

The original version of this article was missing the details of a corresponding author. A notice detailing this has been published and the error rectified in the online pdf and HTML version

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