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Alpha-2 adrenergic receptor function in post-stroke depression

Published online by Cambridge University Press:  09 July 2009

Siobhan Barry  and
Timothy G. Dinan
Siobhan Barry*
Affiliation:
Department of Psychiatry, Trinity College Medical School, St James's Hospital, Dublin, Ireland
Timothy G. Dinan
Affiliation:
Department of Psychiatry, Trinity College Medical School, St James's Hospital, Dublin, Ireland
*
1Address for correspondence: Dr Siobhan Barry, Department of Psychiatry, Trinity College Medical School, St James's Hospital, Dublin 8, Ireland.
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Synopsis

The growth hormone (GH) response to desipramine was measured in ten patients meeting criteria for post-stroke depression (PSD), eight age-matched post-stroke (PS) nondepressed patients and eight healthy controls. Responses were significantly blunted in patients with PSD. These findings suggest diminished alpha-2 adrenoceptor function may be an important marker for PSD.

Type
Original Articles
Information
Psychological Medicine , Volume 20 , Issue 2 , May 1990 , pp. 305 - 309
Copyright
Copyright © Cambridge University Press 1990

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