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Psychological Medicine Psychological Medicine

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Socio-demographic and trauma-related predictors of depression within eight weeks of motor vehicle collision in the AURORA study

Published online by Cambridge University Press:  29 October 2020

Jutta Joormann ,
Samuel A. McLean ,
Francesca L. Beaudoin ,
Xinming An ,
Jennifer S. Stevens ,
Donglin Zeng ,
Thomas C. Neylan ,
Gari Clifford ,
Sarah D. Linnstaedt  and
Laura T. Germine
...Show all authors
Jutta Joormann*
Affiliation:
Department of Psychology, Yale University, New Haven, CT, USA
Samuel A. McLean
Affiliation:
Department of Anesthesiology, Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Francesca L. Beaudoin
Affiliation:
Department of Emergency Medicine, The Alpert Medical School of Brown University, Providence, RI, USA Department of Health Services, Policy and Practice, Brown University School of Public Health, Providence, RI, USA Rhode Island Hospital, Providence, RI, USA The Miriam Hospital, Providence, RI, USA
Xinming An
Affiliation:
Department of Anesthesiology, Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Jennifer S. Stevens
Affiliation:
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
Donglin Zeng
Affiliation:
Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
Thomas C. Neylan
Affiliation:
San Francisco VA Healthcare System, San Francisco, CA, USA Departments of Psychiatry and Neurology, University of California, San Francisco, CA, USA
Gari Clifford
Affiliation:
Department of Biomedical Informatics, Emory University School of Medicine and Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA
Sarah D. Linnstaedt
Affiliation:
Department of Anesthesiology, Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Laura T. Germine
Affiliation:
Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA The Many Brains Project, Acton, MA, USA
Scott L. Rauch
Affiliation:
Department of Psychiatry, McLean Hospital, Belmont, MA, USA
Paul I. Musey
Affiliation:
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Phyllis L. Hendry
Affiliation:
Department of Emergency Medicine, University of Florida College of Medicine – Jacksonville, Jacksonville, FL, USA
Sophia Sheikh
Affiliation:
Department of Emergency Medicine, University of Florida College of Medicine – Jacksonville, Jacksonville, FL, USA
Christopher W. Jones
Affiliation:
Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ, USA
Brittany E. Punches
Affiliation:
Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA University of Cincinnati College of Nursing, Cincinnati, OH, USA
Gregory Fermann
Affiliation:
Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Lauren A. Hudak
Affiliation:
Department of Emergency Medicine, Emory University, Grady Memorial Hospital, Atlanta, GA, USA
Kamran Mohiuddin
Affiliation:
Department of Emergency Medicine/Internal Medicine, Einstein Medical Center, Philadelphia, PA, USA
Vishnu Murty
Affiliation:
Department of Psychology, Temple University, Philadelphia, PA, USA
Meghan E. McGrath
Affiliation:
Departmentof Emergency Medicine, Boston Medical Center, Boston, MA, USA
John P. Haran
Affiliation:
Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Jose Pascual
Affiliation:
Department of Surgery and Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Mark Seamon
Affiliation:
Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, USA
David A. Peak
Affiliation:
Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA
Claire Pearson
Affiliation:
Wayne State University Department of Emergency Medicine, Ascension St. John Hospital, Detroit, MI, USA
Robert M. Domeier
Affiliation:
Department of Emergency Medicine, Saint Joseph Mercy Hospital, Ann Arbor, MI, USA
Paulina Sergot
Affiliation:
Department of Emergency Medicine, University of Texas Health Science Center, Houston, TX, USA
Roland Merchant
Affiliation:
Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA
Leon D. Sanchez
Affiliation:
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA
Niels K. Rathlev
Affiliation:
Department of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, USA
William F. Peacock
Affiliation:
Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA
Steven E. Bruce
Affiliation:
Department of Psychological Sciences, University of Missouri – St. Louis, St. Louis, MO, USA
Deanna Barch
Affiliation:
Departments of Psychological & Brain Sciences, Psychiatry, and Radiology, Washington University in St. Louis, St. Louis, MO, USA
Diego A. Pizzagalli
Affiliation:
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Beatriz Luna
Affiliation:
Laboratory of Neurocognitive Development, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Steven E. Harte
Affiliation:
Departments of Anesthesiology and Internal Medicine-Rheumatology, Chronic Pain and Fatigue Research Center, University of Michigan Medical School, Ann Arbor, MI, USA
Irving Hwang
Affiliation:
Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
Sue Lee
Affiliation:
Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
Nancy Sampson
Affiliation:
Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
Karestan C. Koenen
Affiliation:
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA
Kerry J. Ressler
Affiliation:
Department of Psychiatry, Harvard Medical School, Boston, MA, USA Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA
Ronald C. Kessler
Affiliation:
Department of Health Care Policy, Harvard Medical School, Boston, MA, USA Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA
*
Author for correspondence: Jutta Joormann, E-mail: jutta.joormann@yale.edu
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Abstract

Background

This is the first report on the association between trauma exposure and depression from the Advancing Understanding of RecOvery afteR traumA(AURORA) multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience.

Methods

We focus on participants presenting at EDs after a motor vehicle collision (MVC), which characterizes most AURORA participants, and examine associations of participant socio-demographics and MVC characteristics with 8-week depression as mediated through peritraumatic symptoms and 2-week depression.

Results

Eight-week depression prevalence was relatively high (27.8%) and associated with several MVC characteristics (being passenger v. driver; injuries to other people). Peritraumatic distress was associated with 2-week but not 8-week depression. Most of these associations held when controlling for peritraumatic symptoms and, to a lesser degree, depressive symptoms at 2-weeks post-trauma.

Conclusions

These observations, coupled with substantial variation in the relative strength of the mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated in more in-depth analyses of the rich and evolving AURORA database to find new targets for intervention and new tools for risk-based stratification following trauma exposure.

Keywords

AnxietydepressionPTSDtrauma
Type
Original Articles
Information
Psychological Medicine , First View , pp. 1 - 14
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Copyright
Copyright © The Author(s) 2020. Published by Cambridge University Press

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