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Pre-adult versus adult onset major depressive disorder in a naturalistic patient sample: the Leiden Routine Outcome Monitoring Study

Published online by Cambridge University Press:  16 November 2010

M. S. van Noorden ,
S. E. Minkenberg ,
E. J. Giltay ,
M. E. den Hollander-Gijsman ,
Y. R. van Rood ,
N. J. van der Wee  and
F. G. Zitman
M. S. van Noorden*
Affiliation:
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
S. E. Minkenberg
Affiliation:
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
E. J. Giltay
Affiliation:
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
M. E. den Hollander-Gijsman
Affiliation:
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands Rivierduinen, Mental Health Clinics, Leiden, The Netherlands
Y. R. van Rood
Affiliation:
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
N. J. van der Wee
Affiliation:
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands Leiden Institute for Brain and Cognition, Leiden, The Netherlands
F. G. Zitman
Affiliation:
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands Rivierduinen, Mental Health Clinics, Leiden, The Netherlands
*
*Address for correspondence: M. S. van Noorden, M.D., Department of Psychiatry, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. (Email: m.s.van_noorden@lumc.nl)
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Abstract

Background

Pre-adult onset of major depressive disorder (MDD) may predict a more severe phenotype of depression. As data from naturalistic psychiatric specialty care settings are scarce, we examined phenotypic differences between pre-adult and adult onset MDD in a large sample of consecutive out-patients.

Method

Altogether, 1552 out-patients, mean age 39.2±11.6 years, were diagnosed with current MDD on the Mini-International Neuropsychiatric Interview Plus diagnostic interview as part of the usual diagnostic procedure. A total of 1105 patients (71.2%) had complete data on all variables of interest. Pre-adult onset of MDD was defined as having experienced the signs and symptoms of a first major depressive episode before the age of 18 years. Patients were stratified according to the age at interview (20–40/40–65 years). Correlates of pre-adult onset were analysed using logistic regression models adjusted for age, age squared and gender.

Results

Univariate analyses showed that pre-adult onset of MDD had a distinct set of demographic (e.g. less frequently living alone) and clinical correlates (more co-morbid DSM-IV – Text Revision diagnoses, more social phobia, more suicidality). In the multivariate model, we found an independent association only for a history of suicide attempts [odds ratio (OR) 3.15, 95% confidence intervals (CI) 1.97–5.05] and current suicidal thoughts (OR 1.81, 95% CI 1.26–2.60) in patients with pre-adult versus adult onset MDD.

Conclusions

Pre-adult onset of MDD is associated with more suicidality than adult onset MDD. Age of onset of depression is an easy to ascertain characteristic that may help clinicians in weighing suicide risk.

Keywords

Depressiononsetroutine outcome monitoring
Type
Original Articles
Information
Psychological Medicine , Volume 41 , Issue 7 , July 2011 , pp. 1407 - 1417
Copyright
Copyright © Cambridge University Press 2010

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