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Plasma vanadium concentration in manic-depressive illness

Published online by Cambridge University Press:  09 July 2009

David A. T. Dick ,
Graham J. Naylor  and
Elizabeth G. Dick
David A. T. Dick*
Affiliation:
Department of Anatomy and Psychiatry, The University, Dundee
Graham J. Naylor
Affiliation:
Department of Anatomy and Psychiatry, The University, Dundee
Elizabeth G. Dick
Affiliation:
Department of Anatomy and Psychiatry, The University, Dundee
*
1Address for correspondence: Professor D. A. T. Dick, Department of Anatomy, The University, Dundee DDI 4HN.
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Synopsis

133 samples of plasma taken from 9 normal control and 8 manic-depressive subjects were analysed for vanadium by atomic absorption spectrometry. Mean plasma vanadium concentrations were 0·15 μM in normal control, 0·34 μM in manic and 0·28 μM in depressed subjects, and 0·23 μM in manic-depressive subjects after recovery. The differences between normal subjects and manic and recovered subjects were statistically significant. Significant negative correlations were found between plasma vanadium concentration and the ratio of Na–K–Mg ATPase to Mg–ATPase in 2 manic-depressive subjects, but not in normal subjects. The results suggest that vanadium may be a cause of the variations in Na–K–Mg ATPase and sodium pump activity which are associated with manic-depressive illness.

Type
Research Article
Information
Psychological Medicine , Volume 12 , Issue 3 , August 1982 , pp. 533 - 537
Copyright
Copyright © Cambridge University Press 1982

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References

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