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Effects of rapid tryptophan depletion in patients with seasonal affective disorder in natural summer remission

Published online by Cambridge University Press:  01 January 2000

R. W. LAM
Affiliation:
Division of Mood Disorders, Department of Psychiatry, University of British Columbia and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
T. A. BOWERING
Affiliation:
Division of Mood Disorders, Department of Psychiatry, University of British Columbia and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
E. M. TAM
Affiliation:
Division of Mood Disorders, Department of Psychiatry, University of British Columbia and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
A. GREWAL
Affiliation:
Division of Mood Disorders, Department of Psychiatry, University of British Columbia and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
L. N. YATHAM
Affiliation:
Division of Mood Disorders, Department of Psychiatry, University of British Columbia and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
I. S. SHIAH
Affiliation:
Division of Mood Disorders, Department of Psychiatry, University of British Columbia and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
A. P. ZIS
Affiliation:
Division of Mood Disorders, Department of Psychiatry, University of British Columbia and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada

Abstract

Background. Serotonergic mechanisms have been proposed for the pathophysiology of seasonal affective disorder (SAD) and the therapeutic effect of bright-light treatment. Previously, we showed that SAD patients, in clinical remission with light therapy during the winter, experienced transient depressive relapses after a rapid tryptophan depletion (RTD) technique, which results in decreased brain serotonin levels. The objective of this study was to investigate the effect of RTD in SAD patients who were in natural summer remission.

Methods. Twelve drug-free patients with SAD by DSM-IV criteria and 10 normal subjects participated in this double-blind, placebo-controlled, crossover study. SAD patients were in natural summer remission for at least 8 weeks. Behavioural ratings and plasma tryptophan levels were obtained before, and 5 h after, ingesting an amino acid (AA) mixture±tryptophan. Experimental RTD and control sessions were scheduled 1 week apart.

Results. The RTD session resulted in significant reduction in total and free plasma tryptophan levels compared to the control session. The behavioural data were analysed using repeated measures analysis of variance. This analysis found significant main effects of time (higher scores after AA ingestion) and diagnosis (higher scores in SAD patients), but no main effect of session or significant interaction effects between the three factors. Thus, there were no significant behavioural effects of RTD compared to the sham depletion control session.

Conclusions. The summer remission experienced by SAD patients is not dependent on plasma tryptophan levels (and presumably brain serotonin function) in the same manner as that of remission after light therapy. These results conflict with those of other laboratories, perhaps because of differences in study samples.

Type
Research Article
Copyright
© 2000 Cambridge University Press

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