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Cerebrospinal fluid somatostatin in delirium

Published online by Cambridge University Press:  09 July 2009

Hannu Koponen ,
Ulla Stenbäck ,
Esa Mattila ,
Kari Reinikainen ,
Hilkka Soininen  and
Paavo J. Riekkinen
Hannu Koponen*
Affiliation:
Department of Neurology, University Central Hospital of Kuopio, SF-70210 Kuopio and Moisio Hospital, SF-50520 Mikkeli, Finland
Ulla Stenbäck
Affiliation:
Department of Neurology, University Central Hospital of Kuopio, SF-70210 Kuopio and Moisio Hospital, SF-50520 Mikkeli, Finland
Esa Mattila
Affiliation:
Department of Neurology, University Central Hospital of Kuopio, SF-70210 Kuopio and Moisio Hospital, SF-50520 Mikkeli, Finland
Kari Reinikainen
Affiliation:
Department of Neurology, University Central Hospital of Kuopio, SF-70210 Kuopio and Moisio Hospital, SF-50520 Mikkeli, Finland
Hilkka Soininen
Affiliation:
Department of Neurology, University Central Hospital of Kuopio, SF-70210 Kuopio and Moisio Hospital, SF-50520 Mikkeli, Finland
Paavo J. Riekkinen
Affiliation:
Department of Neurology, University Central Hospital of Kuopio, SF-70210 Kuopio and Moisio Hospital, SF-50520 Mikkeli, Finland
*
1Address for correspondence: Dr Hannu Koponen, Kirkkokatu 33 B 26, SF-70100 Kuopio, Finland.
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Synopsis

Cerebrospinal fluid somatostatin-like immunoreactivity (CSF SLI) was determined for 67 elderly patients who met the DSM-III criteria for delirium and for 19 age-matched controls. As a group, and also when subdivided according to the type of delirium, severity of cognitive decline or the type of central nervous system disease, the delirious patients showed significant reductions of SLI compared with the controls, together with a declining trend associated with increasing cognitive dysfunction. These findings are in accordance with previous observations that reduced CSF SLI is associated with diseases in which cognitive function is disturbed and they extend this finding to delirium.

Type
Original Articles
Information
Psychological Medicine , Volume 19 , Issue 3 , August 1989 , pp. 605 - 609
Copyright
Copyright © Cambridge University Press 1989

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