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The L6 membrane proteins—A new four-transmembrane superfamily

Published online by Cambridge University Press:  01 August 2000

MARK D. WRIGHT
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, 3050 Victoria, Australia
JIAN NI
Affiliation:
Human Genome Sciences, 9410 Key West Avenue, Rockville, Maryland 20850
GEORGE B. RUDY
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, 3050 Victoria, Australia
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Abstract

L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily. In this paper, we identify a new sequence (L6D) that is strikingly similar to L6, IL-TMP, and TM4SF5. Analyses of these four sequences indicate that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 superfamily.

Type
FOR THE RECORD
Copyright
© 2000 The Protein Society

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