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Kinetic evidence of an on-pathway intermediate in the folding of lysozyme

Published online by Cambridge University Press:  01 January 2000

YAWEN BAI
YAWEN BAI
Affiliation:
Laboratory of Biochemistry, National Cancer Institute, NIH Building 37, Room 4A-01, Bethesda, Maryland 20850
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Abstract

By means of a kinetic test, it was demonstrated that one of the folding intermediates (Iα) of hen lysozyme with α-domain folded and β-domain unfolded is on the folding pathway under the classical definition. Iα folds to the native (N) state directly (unfolded (U) [hArr ] Iα [hArr ] N) without having to unfold to U and then refold to N through alternative folding pathways as in Iα [hArr ] U [hArr ] N.

Keywords

hen egg white lysozymeoff-pathway intermediateon-pathway intermediateprotein folding pathway
Type
FOR THE RECORD
Information
Protein Science , Volume 9 , Issue 1 , January 2000 , pp. 194 - 196
Copyright
© 2000 The Protein Society

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