One of us (D. N. P.) has shown in the preceding paper that chloroform, when administered to dogs by the respiratory passages, may produce a purely stimulating action upon hepatic metabolism; whereas when it is given by the mouth, and to a less extent when it is given hypodermically, it exercises a distinctly toxic action, decreasing the activity of hepatic metabolism and leading to degenerative changes in the liver cells.

In attempting to find an explanation of these phenomena, it was necessary to know whether any difference existed in the distribution of the drug throughout the system after it had been given by these channels.

To elucidate this, the following series of observations were undertaken upon rabbits.