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Growth control of normal and malignant breast epithelium

Published online by Cambridge University Press:  05 December 2011

Marc E. Lippman  and
Robert B. Dickson
Marc E. Lippman
Affiliation:
Lombardi Cancer Research Center, Georgetown University Medical Center, 3800 Reservoir Road, N.W., Washington, DC 20007, U.S.A.
Robert B. Dickson
Affiliation:
Lombardi Cancer Research Center, Georgetown University Medical Center, 3800 Reservoir Road, N.W., Washington, DC 20007, U.S.A.
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Synopsis

We review information highlighting the multiple roles of both steroidal (primarily oestrogen) and polypeptide regulators of mammary epithelial cell growth, emphasising the work of our laboratory. Effects of both classes of hormones are complex and involve multiple interactions with non-tumour, host tissue. Oestrogen may induce growth regulatory polypeptide growth factors and interact with them in hormone dependent breast cancer. Progression of hormone-dependent breast cancer to hormone independence may involve multiple genetic mechanisms of oncogene activation, loss of the oestrogen receptor, or loss of hormone responsivity of other gene products. Initial carcinogenesis and progression of mammary epithelium to cancer probably also requires both proliferative stimuli (oestrogen, polypeptide growth factors) and genetic damage, leading to qualitatively different hormonal responses (hormone responsive cancer). Future therapies should be designed to block hormonal stimulation better and to interfere with necessary activated or induced components of malignant progression such as oncogenes or polypeptide growth factors receptor systems.

Type
Research Article
Information
Proceedings of the Royal Society of Edinburgh, Section B: Biological Sciences , Volume 95: Oestrogen and the Human Breast , 1989 , pp. 89 - 106
Copyright
Copyright © Royal Society of Edinburgh 1989

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References

Abraham, J. A., Whang, J. L., Tumolo, A., Mergia, A., Friedman, J., Gospodorowicz, D. & Fiddles, J. C. 1986. Human basic fibroblast growth factor: nucleotide sequence and genomic organization. EMBO Journal 5, 2523–2528.CrossRefGoogle ScholarPubMed
Arteaga, C. L., Kitten, L., Coronado, E., Jacobs, I., Kull, F. & Osborne, C. K. 1988. Blockade of the type I somatomedin receptor inhibits growth of estrogen receptor negative human breast cancer cells in athymic nude mice. Proceedings of the Annual Meeting of the Endocrine Society, Abstract 683.Google Scholar
Assoian, R. K., Grotendorst, G. R., Miller, D. M. & Sporn, M. B. 1984. Cellular transformation by coordinated action of three peptide growth factors from human platelets. Nature (London) 309, 804–806.CrossRefGoogle ScholarPubMed
Bates, S. E., McManaway, M. E., Lippman, M. E. & Dickson, R. B. 1986. Characterization of estrogen responsive transforming activity in human breast cancer cell lines. Cancer Research 46, 1707–1713.Google Scholar
Bates, S. E., Davidson, N. E., Valverius, E., Freter, C., Dickson, R. B., Tam, J. D., Kudlow, J. E., Lippman, M. E. & Salomon, D. S. 1988. Expression of transforming growth factor alpha and its messenger ribomekic acid in human breast cancer: its regulation by estrogen and its possible functional significance. Molecular Endocrinology 2, 543–555.CrossRefGoogle ScholarPubMed
Baxter, R. C., Maitland, J. E., Raisur, R. L., Reddel, R. & Sutherland, R. L. 1983. High molecular weight somatomedin-C (IGF-I) from T47D human mammary carcinoma cells: immunoreactivity and bioactivity. In Insulin-like Growth Factors/Somatomedins, ed. Spencer, E. M., pp. 615–618. Berlin: Walter deGruyter Co.Google Scholar
Beatson, G. T. 1896. On the treatment of inoperable cases of carcinoma of the mamma; suggestions for a new method of treatment with illustrative cases. Lancet 2, 104–107, 162–165.CrossRefGoogle Scholar
Beebe, D. C., Silver, M. H., Belcher, K. S., Van Wyk, J. J., Svoboda, M. E. & Zelenka, P. S. 1987. Lentropin, a protein that controls less fiber formation, is related functionally and immunologically to the insulin-like growth factors. Proceedings of the National Academy of Sciences of the U.S.A. 84, 2327–2330.CrossRefGoogle Scholar
Berthois, Y., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. 1986. Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. Proceedings of the National Academy of Sciences of the U.S.A. 83, 2496–2500.CrossRefGoogle Scholar
Betsholtz, C., Hohnsson, A., Heldin, C. H., Westermark, B., Lind, P., Urdea, M. S., Eddy, R., Shows, T. B., Philpott, K., Mellor, A. L., Knott, T. J. & Scott, J. 1986. cDNA sequence and chromosomal localization of human platelet derived growth factor A chain and its expression in tumor cell lines. Nature 320, 695–700.CrossRefGoogle Scholar
Bishop, J. M. 1987. The molecular genetics of cancer. Science 235, 305–311.CrossRefGoogle ScholarPubMed
Bohmann, D., Bos, T. J., Admon, A., Nishimura, T., Vogt, P. K. & Tjian, R. 1987. Human protooncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238, 1386–1392.CrossRefGoogle ScholarPubMed
Bradshaw, G. L. & Dubes, G. R. 1984. Polyoma virus transformation of rat kidney fibroblasts results in loss of requirement for insulin and retinoic acid. Journal of General Virology 64, 2311–2315.CrossRefGoogle Scholar
Bringman, T. S., Lindquist, P. B. & Derynck, R., 1987. Different transforming growth factor α species are derived from a glycosylated and palmitolated transmembrane precursor. Cell 48, 429–440.CrossRefGoogle ScholarPubMed
Bronzert, D. A., Pantazis, P., Antoniades, H. N., Kasid, A., Davidson, N., Dickson, R. B. & Lippman, M. E. 1987. Synthesis and secretion of PDGF-like growth factor by human breast cancer cell lines. Proceedings of the National Academy of Sciences of the U.S.A. 84, 5763–5767.CrossRefGoogle ScholarPubMed
Brooks, S. C., Locke, E. R. & Soule, H. D. 1973. Estrogen receptor in a human breast cell line (MCF-7) from breast carcinoma. Journal of Biological Chemistry 248, 6251–6261.CrossRefGoogle Scholar
Butler, W. B., Kelsey, W. H. & Goran, N. 1981. Effects of serum and insulin on the sensitivity of the human breast cancer cell line MCF-7 to estrogens and antiestrogens. Cancer Research 41, 82–88.Google ScholarPubMed
Carpenter, G., Stoscheck, C. M., Preston, Y. A. & Delarco, J. E. 1983. Antibodies to the epidermal growth factor receptor block the biological activities of sarcoma growth. Proceedings of the National Academy of Sciences of the U.S.A. 80, 5627–5630.CrossRefGoogle Scholar
Carter, R. L., Mattallano, R. J., Hession, C., Trizard, R., Farber, N. M., Cheung, A., Ninfa, E. G., Frey, A. Z., Gash, D. J., Chow, E. P., Fisher, R. A., Bertonis, J. M., Tower, G., Wanner, B. P., Ramachandran, K. L., Ragin, R. C., Manganaro, T. F., MacLaughlin, D. T. & Donahoe, P. K. 1987. Isolation of the bovine and human genes for Mullerian inhibiting substance and expression of the human gene in animal cells. Cell 45, 685–698.Google Scholar
Chablos, D. & Rochefort, H. 1984. Dual effects of progestin R5020 on protein released by the T47D human breast cancer cells. Journal of Biological Chemistry 259, 1231–12380.Google Scholar
Chakrabarty, S., Toborn, A., Varani, J. & Brattain, M. G. 1988. Induction of carcinoembrogonic antigen secretion and modulation of protein secretion/expression and fibronectron/laminin expression in human colin carcinoma cells by TGFβ. Cancer Research 48, 4059–4069.Google Scholar
Cherington, P. V., Smith, B. L. & Pardee, A. B. 1979. Loss of epidermal growth factor requirement and malignant transformation. Proceedings of the National Academy of Sciences of the U.S.A. 76, 3937–3942.CrossRefGoogle ScholarPubMed
Clark, R., Stampfer, M. R., Milley, R., O'Rourke, E., Walen, K. H., Kriegler, M., Kopplin, J. & McCormick, F. 1988. Transformation of human mammary epithelial cells by oncogenic retroviruses. Cancer Research (in press).Google Scholar
Clemmons, D. R. & Shaw, D. S. 1983. Variables controlling somatomedin production by cultured human fibroblasts. Journal of Cellular Physiology 115, 137–143.CrossRefGoogle ScholarPubMed
Clemmons, D. R. & Shaw, D. S. 1986. Purification and biological properties of fibroblast somatomedin. Journal of Biological Chemistry 261, 10293–10298.CrossRefGoogle ScholarPubMed
Clemmons, D. R. & Van Wyk, J. J. 1986. Evidence for a functional role of endogenously produced somatomedin-like peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cells. Journal of Clinical Investigation 75, 1914–1918.CrossRefGoogle Scholar
Cline, M. J., Buttitora, H. & Yokota, J. 1987. Protooncogene abnormalities in human breast cancer: correlations with anatomic features and clinical course of disease. Journal of Clinical Oncology 5, 999–1006.CrossRefGoogle ScholarPubMed
Coffey, R. J., Leof, E. B., Shipley, G. D. & Moses, H. L. 1987. Suramin inhibition of growth factor receptor binding and mitogenicity in AKR-2β cells. Journal of Cellular Physiology 132, 143–148.CrossRefGoogle ScholarPubMed
Cohen, S. 1962. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the newborn animal. Journal of Biological Chemistry 237, 1555–1562.CrossRefGoogle Scholar
Coughlin, S. R., Barr, P. J., Cousens, L. S., Fretto, L. J. & Williams, L. T. 1988. Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo. Journal of Biological Chemistry 263, 988–993.CrossRefGoogle ScholarPubMed
Cullen, K. J., Yee, D., Paik, S., Hampton, B., Perdue, J. F., Lippman, M. E. & Rosen, N. 1988. Insulin-like growth factor II expression and activity in human breast cancer. Proceedings of the 79th Annual Meeting of the American Association for Cancer Research, Abstract 947.Google Scholar
D'Ercole, A. J., Applewhite, G. T. & Underwood, L. E. 1980. Evidence that somatomedin is synthesized by multiple tissues in the fetus. Developmental Biology 75, 315–328.CrossRefGoogle ScholarPubMed
Darbre, P., Yates, J., Curtis, S. & King, R. J. B. 1983. Effect of estradiol on human breast cancer cells in culture. Cancer Research 43, 349–354.Google ScholarPubMed
Daughaday, W. H., Hall, K., Salmon, W. D., Van den Brande, J. L. & Van Wyk, J. J. 1987. On the nomenclature of the somatomedins and insulin-like growth factors. Endocrinology 121, 1911–1912.CrossRefGoogle ScholarPubMed
Dehoff, M. H., Elgin, R. G., Collier, R. J. & Clemmons, D. R. 1988. Both type I and II insulin-like growth factor receptor binding increase during lactogenesis in bovine mammary tissue. Endocrinology 122, 2412–2417.CrossRefGoogle ScholarPubMed
Delarco, J. E. & Todaro, G. J. 1978. Growth factors from murine sarcoma virus-transformed cells. Proceedings of the National Academy of Sciences of the U.S.A. 75, 4001–4005.CrossRefGoogle Scholar
DeLeon, D. D., Bakker, B., Wilson, D. M., Hintz, R. L. & Rosenfeld, R. G. 1988. Demonstration of insulin-like growth factor (IGF-I and -II) receptors and binding protein in human breast cancer cell lines. Biochemistry Biophysics Research Communication 152, 398–405.CrossRefGoogle Scholar
DelliBovi, P., Gurutola, A. M., Kern, F. G., Greco, A., Ittmann, M. & Basilico, C. 1987. An oncogene isolated by transfection of Kaposi Sarcoma DNA encodes a growth factor that is a member of the FGF family. Cell 50, 729–737.Google Scholar
Dempsey, P. J., Feleppa, F. P., Brown, R. W., deKretser, T. A., Whitehead, R. H. & Jose, D. G. 1986. Development of monoclonal antibodies to the human breast carcinoma cell line PMC42. Journal of the National Cancer Institute 77, 1–15.Google Scholar
Derynck, R., Roberts, A. B., Winkler, M. E., Chen, E. Y. & Goeddel, D. V. 1984. Human transforming growth factor α-precursor structure and expression in E. coli. Cell 38, 287–297.Google Scholar
Derynck, R., Jarret, J. A., Chen, E. Y., Eaton, D. H., Bell, J. R., Assoian, R. K., Roberts, A. B., Sporn, M. B. & Goeddel, D. V., 1985. Human transforming growth factor β: Complementary DNA sequence and expression in normal and transformed cells. Nature 316, 701–705.CrossRefGoogle ScholarPubMed
Derynck, R., Goeddel, D. V., Ullrich, A., Gutterman, J. U., Williams, R. D., Bringman, T. S. & Berger, W. H. 1987. Synthesis of messenger RNAs for transforming growth factors α and β and the epidermal growth factor receptor by human tumors. Cancer Research 47, 707–712.Google ScholarPubMed
Devleeschouwer, N., Legros, N., Oleu-Serrano, N., Pariduens, R. & Leclereq, G. 1987. Estrogen conjugates and serum factors mediating the estrogenic trophic effect on MCF-7 cell growth. Cancer Research 47, 5883–5887.Google ScholarPubMed
Dickson, C. & Peters, G. 1987. Potential oncogene product related to growth factors. Nature 326, 833.CrossRefGoogle ScholarPubMed
Dickson, R. B., Huff, K. K., Spencer, E. M. & Lippman, M. E. 1986. Induction of epidermal growth factor related polypeptides by 17-beta estradiol in MCF-7 human breast cancer cell lines. Endocrinology 118, 138–142.CrossRefGoogle Scholar
Dickson, R. B., Rosen, N., Gelmann, E. P. & Lippman, M. E. 1987a. Receptor and signal transduction-related protooncogenes in breast cancer. Trends in Pharmacological Science 8, 372–375.CrossRefGoogle Scholar
Dickson, R. B., Kasid, A., Huff, K. K., Bates, S., Knabbe, C., Bronzert, D., Gelmann, E. P. & Lippman, M. E. 1987b. Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17β estradiol or v-rasH oncogene. Proceedings of the National Academy of Sciences of the U.S.A. 84, 837–841.CrossRefGoogle ScholarPubMed
Dickson, R. B., Kasid, A., Huff, K. K., Bates, S., Knabbe, C., Bronzert, D., Gelmann, E. P. & Lippman, M. E. 1986a. Estrogen regulation of growth and polypeptide growth factor secretion in human breast carcinoma. Endocrine Reviews 8, 29–43.CrossRefGoogle Scholar
Dickson, R. B., Kasid, A., Huff, K. K., Bates, S., Knabbe, C., Bronzert, D., Gelmann, E. P. & Lippman, M. E. 1986b. Role of estrogen in malignant progression of breast cancer; New perspectives. Trends in Pharmacological Sciences 7, 294–296.CrossRefGoogle Scholar
Edwards, D. P., Murphy, S. L. & McGuire, W. L. 1980. Effect of estrogen and antiestrogen on DNA polymerase in human breast cancer. Cancer Research 40, 1722–1726.Google ScholarPubMed
Eidne, K. A., Flanagan, C. A. & Millar, R. P. 1985. Gonadotrophin-releasing hormone binding sites in human breast carcinoma. Science 229, 989–991.CrossRefGoogle ScholarPubMed
Engle, L. W. & Young, N. W. 1978. Human breast carcinoma cells in continuous culture: a review. Cancer Research 38, 4327–4339.Google Scholar
Esch, F., Baird, A., Ling, N., Uena, N., Hill, F., Denoroy, L., Klepper, R., Gospodorowicz, D., Bohlen, P. & Guillemin, R. 1985. Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain FGF. Proceedings of the National Academy of Sciences of the U.S.A. 82, 6507–6511.CrossRefGoogle Scholar
Fidler, I. J., Gersten, D. M. & Hart, I. R. 1978. The biology of cancer invasion and metastatis. Advances in Cancer Research 28, 149–160.CrossRefGoogle Scholar
Flier, J. S., Usher, P. & Moses, A. E. 1986. Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts. Proceedings of the National Academy of Sciences of the U.S.A. 83, 664–668.CrossRefGoogle Scholar
Folkman, J. 1986. How is blood vessel growth regulated in normal and neoplastic tissue. Cancer Research 216, 467–473.Google Scholar
Folkman, J. & Klagsbrun, M. 1987. Angiogenic factors. Science 235, 442–447.CrossRefGoogle ScholarPubMed
Freedman, V. H. & Shin, S. 1974. Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium. Cell 3, 355–359.CrossRefGoogle ScholarPubMed
Furlanetto, R. W. & DiCarlo, J. N. 1984. Somatomedin C receptors and growth effects in human breast cells maintained in long-term culture. Cancer Research 44, 2122–2128.Google Scholar
Gentry, L. E., Twardzik, D. R., Lim, G. J., Ranchalis, J. E. & Lee, D. C. 1987. Expression and characterization of transforming growth factor precursor protein in transfected mammalian cells. Molecular Cellular Biology 7, 1585–1591.Google ScholarPubMed
Greene, G. L., Sobel, N. B., King, W. J. & Jensen, E. V. 1984. Immunological studies of estrogen receptors. Journal of Steroid Biochemistry 20, 51–56.CrossRefGoogle Scholar
Halper, J. & Moses, H. L. 1983. Epithelial tissue-derived growth factor-like polypeptides. Cancer Research 43, 1972–1979.Google ScholarPubMed
Halper, J. & Moses, H. L. 1987. Purification and characterization of a novel transforming growth factor. Cancer Research 47, 4552–4559.Google ScholarPubMed
Hammond, S. L., Ham, R. G. & Stampfer, M. R., 1984. Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract. Proceedings of the National Academy of Sciences of the U.S.A. 81, 5435–5439.CrossRefGoogle ScholarPubMed
Han, V. K., D'Ercole, A. J. & Lund, P. K. 1987. Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in the human fetus. Science 236, 193–197.CrossRefGoogle ScholarPubMed
Harri, J., Pierce, S. B., Morgan, D. O., Sara, V., Smith, M. C. & Rotz, R. A. 1987. The receptor for insulin-like growth factor II mediates an insulin-like response. The EMBO Journal 6, 3367–3371.CrossRefGoogle Scholar
Heldin, C. H. & Westermark, B. 1984. Growth factors: mechanism of action and relations to oncogenes. Cell 37, 9–20.CrossRefGoogle ScholarPubMed
Hizuka, N., Takano, K., Tanaka, I., Asakawa, K., Miyakawa, M., Horikawa, R. & Shizumi, K. 1987. Demonstration of insulin-like growth factor I in human urine. Journal of Clinical Endocrinology and Metabolism 64, 1309–1316.CrossRefGoogle ScholarPubMed
Huang, J. S., Huang, S. S. & Deuel, T. F., 1984. Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell surface receptors. Cell 39, 79–87.CrossRefGoogle ScholarPubMed
Huff, K. K., Kaufman, D., Gabbay, K. H., Spencer, E. M., Lippman, M. E. & Dickson, R. B. 1986. Human breast cancer cells secrete an insulin-like growth factor-1-related polypeptide. Cancer Research 46, 4613–4619.Google Scholar
Huff, K. K., McManaway, M., Paik, S. & Brunner, N. 1988a. In vivo effects of insulin-like growth factor-I (IGF-I) on tumor formation by MCF-7 human breast cancer cells in athymic mice. Proceedings of the 70th Annual Meeting of the Endocrine Society, Abstract 878.Google Scholar
Huff, K. K., Knabbe, C., Lindsay, R., Lippman, M. E. & Dickson, R. B. 1988b. Multihormonal regulation of insulin-like growth factor-I-related protein in MCF-7 human breast cancer cells. Molecular Endocrinology 2, 200–208.CrossRefGoogle ScholarPubMed
Huggins, C. & Clark, P. J. 1940. Quantitative studies of prostatic secretion. Journal of Experimental Medicine 72, 747–762.CrossRefGoogle ScholarPubMed
Hynes, M. A., Van Wyk, J. J., Brooks, P. J., D'Ercole, A. J., Jansen, M. & Lund, P. K. 1987. Growth hormone dependence of somatomedin C/insulin-like growth factor-I and insulin-like growth factor-II messenger ribonucleic acids. Molecular Endocrinology 1, 233–242.CrossRefGoogle ScholarPubMed
Ignotz, R. A., Kelly, B., Davis, R. J. & Massague, J. 1986. Biologically active precursor for transforming growth factor type α released by retrovirally transformed cells. Proceedings of the National Academy of Sciences of the U.S.A. 83, 6307–6311.CrossRefGoogle ScholarPubMed
Ignotz, R. A., Kelly, B., Davis, R. J. & Massague, J. 1986. Transforming growth factor β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. Journal of Biological Chemistry 261, 4337–4345.CrossRefGoogle ScholarPubMed
Ikeda, T., Danielpour, D. & Sirbasku, B. A., 1983. Isolation and properties of endocrine and autocrine type mammary tumor cell growth factors (estromedins). In Progress in Cancer Research and Therapy, Vol. 31, eds Bresciani, F., King, R. J. B., Lippman, M. E., Namer, M., and Raynaud, J. P., pp. 171–186. New York: Raven Press.Google Scholar
Jansen, M., Van Schaik, F. M. A., Ricker, A. T., Bullock, B., Woods, P. E., Gabbay, K. H., Nussbaum, A. L., Sussenback, J. S. & Vander Branch, J. R. 1983. Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature (London) 306, 609–611.CrossRefGoogle ScholarPubMed
Karey, K. P. & Sirbasku, D. A. 1988. Differential responsiveness of human breast cancer cell lines MCF-7 and T47D to growth factors and 17β-estradiol. Cancer Research 48, 4083–4092.Google Scholar
Katzenellenbogen, B. S., Norman, M. J., Eckert, R. L., Peltz, S. W. & Mangel, W. F. 1983. Bioactivities, estrogen receptor interactions, and plasminogen activator-inducing activities of tamoxifen and hydroxy-tamoxifen isomersin MCF-7 human breast cancer cells. Cancer Research 44, 112–119.Google Scholar
Keating, M. T. & Lewis, L. T., 1988. Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells. Science 239, 914–916.CrossRefGoogle ScholarPubMed
Kiess, W., Haskell, J. F., Lee, L., Greenstein, L. A., Miller, B., Aarons, A. L., Rechler, M. M. & Nissley, P. 1987. An antibody that blocks insulin-like growth factor (IGF) binding to the Type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts. Journal of Biological Chemistry 262, 12745–12751.CrossRefGoogle Scholar
Kimball, E. S., Bohn, W. H., Cockley, K. D., Warren, T. C. & Sherwin, S. A. 1984. Distinct high performance liquid chromatography pattern of transforming growth factor activity in urine of cancer patients as compared with that of normal individuals. Cancer Research 44, 3613–3619.Google ScholarPubMed
King, W. J., DeSombre, E. R., Jensen, E. V. & Greene, G. L. 1985. Comparison of immunocytochemical and steroid binding assays for estrogen receptor in human breast tumors. Cancer Research 45, 294–304.Google ScholarPubMed
Knabbe, C., Lippman, M. W., Wakefield, L., Flanders, K., Kasid, A., Derynck, R. & Dickson, R. B. 1987. Evidence that TGFβ is a hormonally regulated negative growth factor in human breast cancer. Cell 48, 417–428.CrossRefGoogle ScholarPubMed
Knabbe, C., Zugmaier, G., Dickson, R. B. & Lippman, M. E. 1988. Transforming growth factor beta and other growth inhibitory polypeptide in human breast cancer. In Proceedings of the 3rd International Congress on Hormones and Cancer, Hamburg, pp. 258–262. New York: Raven Press.Google Scholar
Lawrence, D. A., Pircher, R., Krycene-Martineirie, A. & Lullien, P. 1984. Normal embryo fibroblasts release transforming growth factors in a latent form. Journal of Cellular Physiology 121, 184–188.CrossRefGoogle Scholar
Lee, B. A., Maher, D. W., Hannink, M. & Donoghue, D. J. 1987. Identification of a signal for nuclear targeting in platelet-derived growth-factor-related molecules. Molecular and Cellular Biology 7, 3527–3537.Google ScholarPubMed
Leof, E. B., Proper, J. A., Goustin, A. J., Shipley, G. D., Dicorleto, P. E. & Moses, H. L. 1986. Induction of c-sis mRNA and activity similar to platelet-derived growth factor: A proposed model for indirect mitogenesis involving autocrine activity. Proceedings of the National Academy of Sciences of the U.S.A. 83, 2453–2457.CrossRefGoogle Scholar
Leung, B. S., Qureshi, S. & Leung, J. S. 1982. Response to estrogen by the human mammary carcinoma cell line CAMA-1. Cancer Research 42, 5060–5066.Google ScholarPubMed
Liotta, L. A. 1985. Mechanisms of cancer invasion and metastases. In Progress in Oncology 1, eds DeVita, V. T., Hellman, A., and Rosenberg, S., pp. 28–41. New York: J. B. Lippincott.Google Scholar
Lippman, M. E. 1983. Efforts to combine endocrine and chemotherapy in the management of breast cancer: do two and two equal three? Breast Cancer Research and Treatment 3, 117–127.CrossRefGoogle ScholarPubMed
Lippman, M. E. 1984. Definition of hormones and growth factors required for optimal proliferation and expression of phenotype response in human breast cancer cells. In Cell Culture Methods for Molecular and Cell Biology, Vol. 2, eds Barnes, D. W., Sirbasku, D. A. & Sato, G. H. pp. 183–200. New York: Alan R. Liss.Google Scholar
Lippman, M. E., Bolan, G. & Huff, K. 1976. The effects of estrogens and antiestrogens on hormone-response human breast cancer in long term tissue culture. Cancer Research 36, 4595–4601.Google Scholar
Liu, S. C., Sanfilippo, B., Perroteau, I., Derynck, R., Salomon, D. S. & Kidwell, W. R. 1987. Expression of transforming growth factor α (TGF α) in differentiated rat mammary tumors: estrogen induction of TGFα production. Molecular Endocrinology 1, 683–692.CrossRefGoogle ScholarPubMed
Lykkesfeldt, A. E. & Briand, P. 1986. Indirect mechanism of oestradiol stimulation of cell proliferation of human breast cancer cell lines. British Journal of Cancer 53, 29–35.CrossRefGoogle ScholarPubMed
Majack, R. A. 1987. Beta-type transforming growth factor specifies organizational behavior in vascular smooth muscle cell cultures. Journal of Cell Biology 105, 465–471.CrossRefGoogle ScholarPubMed
Massague, J., Kelly, B. & Mottola, C. 1985. Stimulation by insulin-like growth factors is required for cellular transformation by type transforming growth factor. Journal of Biological Chemistry 260, 4551–4554.CrossRefGoogle Scholar
Massague, J., Cheifetz, S., Endo, T. & Nadal-Ginard, B. 1986. Type β transforming growth factor is an inhibitor of myogenic differentiation. Proceedings of the National Academy of Sciences of the U.S.A. 83, 8206–8210.CrossRefGoogle ScholarPubMed
McMahon, J. B., Richards, W. L., del Campo, A. A., Song, M.-K. & Thorgeirsson, S. S. 1986. Differential effects of transforming growth factor beta on proliferation of normal and malignant rat liver epithelial cells in culture. Cancer Research 46, 4665–4671.Google ScholarPubMed
Minuto, F., Del Monte, P. D., Baweca, A., Fortini, P., Cariola, G., Catarambone, G. & Giordano, G. 1986. Evidence for an increased somatomedin C/insulin-like growth factor I content in primary human lung tumors. Cancer Research 46, 985–988.Google ScholarPubMed
Morgan, D. O., Edman, J. C., Standring, D. N., Fried, V. A., Smith, M.C., Roth, R. A. & Rutter, W. J. 1987. Insulin-like growth factor II receptor as a multifunctional binding protein. Nature 329, 301–308.CrossRefGoogle ScholarPubMed
Natoli, C., Sica, G., Natoli, V., Serra, A. & Iacobelli, S. 1983. Two new estrogen-supersensitive variants of the MCF-7 human breast cancer cell line. Breast Cancer Research and Treatment 3, 23–32.CrossRefGoogle ScholarPubMed
Nelson, J. N., Clarke, R., McFerran, N. V. & Murphy, R. F. 1987. Morpho-functional effects of phenol red on oestrogen-sensitive breast cancer cells. Biochemical Society Transactions 15, 244.CrossRefGoogle Scholar
Nicholson, G. L. 1987. Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression. Cancer Research 47, 1473–1479.Google Scholar
Nickell, K. A., Halper, J. & Moses, H. L. 1983. Transforming growth factors in solid human malignant neoplasms. Cancer Research 43, 1966–1971.Google ScholarPubMed
Nissley, S. P. & Rechler, M. M. 1984. Insulin-like growth factors: biosynthesis receptors and carrier proteins. In Hormonal Proteins and Peptides. Vol. XII, ed. Li, C. H., pp. 128–203. New York: Academic Press.Google Scholar
Noda, K., Umeda, M. & Ono, T. 1984. Transforming growth factor activity in human colostrum. Gann 75, 109–112.Google ScholarPubMed
Olson, E. N., Sternberg, E., Hu, J. S., Spizz, G. & Wilcox, C. 1986. Regulation of myogenic differentiation by type β transforming growth factor. Journal of Cellular Biology 103, 1799–1805.CrossRefGoogle ScholarPubMed
Osborne, C. K., Hobbs, K. & Trent, J. M. 1987. Biological differences among MCF-7 human breast cancer cell lines from different laboratories. Breast Cancer Research and Treatment 9, 111–121.CrossRefGoogle ScholarPubMed
Padgett, R. W., St. Johnson, R. D. & Gelbart, W. M. 1987. A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor beta family. Nature (London) 325, 81–84.CrossRefGoogle Scholar
Page, M. J., Field, J. K., Everett, N. P. & Green, C. D. 1983. Serum-regulation of the estrogen responsiveness of the human breast cancer cell line MCF-7. Cancer Research 43, 1244–1249.Google ScholarPubMed
Pardee, A. D. 1987. Molecules involved in proliferation of normal and cancer cells. Cancer Research 47, 1488–1491.Google ScholarPubMed
Peres, R., Betsholtz, C., Westermark, B. & Heldin, C. H. 1987. Frequent expression of growth factors for mesendrymal cells in human mammary carcinoma cell lines. Cancer Research 47, 3425–3432.Google ScholarPubMed
Perroteau, E., Salomon, D., Debortali, M., Kidwell, W., Hazarika, P., Pardue, R., Dedman, J. & Tam, J. 1986. Immunologic detection and quantitation of alpha transforming growth factors in human breast carcinoma cells. Breast Cancer Research and Treatment 7, 201–210.CrossRefGoogle ScholarPubMed
Prehn, R. T. & Prehn, L. M. 1987. The autoimmune nature of cancer. Cancer Research 47, 927–932.Google ScholarPubMed
Rechler, M. M. & Nissley, S. P. 1986. Insulin-like growth factor (IGF)/somatomedin receptor subtypes; structure, function and relationships to insulin and IGF carrier proteins. Hormone Research 24, 152–159.CrossRefGoogle ScholarPubMed
Reeve, A. E., Eccles, M. R., Wilkins, R. J., Bell, G. I. & Millon, L. J. 1985. Expression of insulin-like growth factor II transcripts in Wilms tumor. Nature 317, 258–260.CrossRefGoogle Scholar
Reiner, G. C. A. & Katzenellenbogen, B. S. 1986. Characterization of estrogen and in MDA-MB-134 human breast cancer cells. Cancer Research 46, 1124–1131.Google ScholarPubMed
Rizzino, A. 1987. Appearance of high affinity for type β transforming growth factor during differentiation of murine embryonal carcinoma cells. Cancer Research 47, 4386–4390.Google ScholarPubMed
Roberts, A. B., Anzano, M. A., Wakefield, L. M., Roche, N. S., Stern, D. F. & Sporn, M. B. 1985. Type β transforming growth factor: a bifunctional regulator of cellular growth. Proceedings of the National Academy of Sciences of the U.S.A. 82, 119–123.CrossRefGoogle ScholarPubMed
Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U. I., Liotta, L. A., Falanga, V., Kehrl, J. H. & Fauci, A. 1986. Transforming growth factor type β: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proceedings of the National Academy of Sciences of the U.S.A. 83, 4167–4171.CrossRefGoogle ScholarPubMed
Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U. I., Liotta, L. A., Falanga, V., Kehrl, J. H. & Sporn, M. B. 1986. Growth factors and transformation. Cancer Surveys 5, 405–412.Google ScholarPubMed
Rochefort, H. 1987. Do antiestrogens and antiprogestins act as hormone antagonists or receptor-targets drugs in breast cancer? Trends in Pharmacological Sciences 8, 126–128.CrossRefGoogle Scholar
Rogel, S., Weinberg, R. A., Fanning, P. & Klagsbrun, M. 1988. Basic fibroblast peptide transforms cells. Nature 331, 173–175.CrossRefGoogle Scholar
Rohlik, Q. T., Adams, D., Kull, F. C. & Jacobs, S. 1988. An antibody to the receptor for insulin-like growth factor I inhibits the growth of MCF-7 cells in tissue culture. Biochemistry and Biophysics Research Communication 149, 276–281.CrossRefGoogle Scholar
Ross, G. T., Vande Wiele, R. L. & Frantz, A. G. 1981. The ovaries and the breasts. In Textbook of Endocrinology, ed. Williams, R. H., pp. 355–411. Philadelphia: W. B. Saunders.Google Scholar
Ross, R., Raines, E. & Bowen-Pope, D. F., 1986. The biology of platelet-derived growth factor. Cell 46, 155–169.CrossRefGoogle ScholarPubMed
Rotwein, P. 1986. Two insulin-like growth factor I messenger RNAs and expressed in human liver. Proceedings of the National Academy of Sciences of the U.S.A. 83, 77–81.CrossRefGoogle ScholarPubMed
Rozengurt, E. 1986. Early signals in the mitogenic response. Science 234, 161–166.CrossRefGoogle ScholarPubMed
Rozengurt, E., Sinnett-Smith, J. & Taylor-Papadimitriou, J. 1985. Production of PDGF-like growth factor by breast cancer lines. International Journal of Cancer 36, 247–252.CrossRefGoogle Scholar
Rudland, P. S. 1987. Stem cells and the development of mammary cancers in experimental rats and humans. Cancer and Metastatic Reviews 6, 55–83.CrossRefGoogle Scholar
Salomon, D. S., Zweibel, J. A., Bano, M., Losonczy, I., Felnel, P. & Kidwell, W. R. 1984. Presence of transforming growth factors in human breast cancer cells. Cancer Research 44, 4069–4077.Google ScholarPubMed
Salomon, D. S., Kidwell, W. R., Kim, N., Ciardiello, F., Bates, S. E., Valverius, E., Lippman, M. E., Dickson, R. B. & Stampfer, M. 1988. Modulation by estrogen and growth factor of transforming growth factor alpha (TGFα) expression in normal and malignant human mammary epithelial cells. Recent Results in Cancer Research (in press).CrossRefGoogle Scholar
Sasada, R., Kurokawa, T., Iwnane, M. & Igarashi, K. 1988. Transformation of mouse BALB/c 3T3 cells with human basic fibroblast growth factor cDNA. Molecular Cellular Biology 8, 588–594.Google ScholarPubMed
Scott, J., Urdea, M. & Quirogu, M. 1983. Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins. Science 221, 236–240.CrossRefGoogle ScholarPubMed
Silberstein, G. B. & Daniel, C. W. 1987. Reversible inhibition of mammary gland growth by transforming growth factor β. Science 237, 291–295.CrossRefGoogle ScholarPubMed
Simon, W. E., Albrecht, M., Trams, G., Dietel, M. & Holzer, F. 1984. In vitro growth promotion of human mammary carcinoma cells by steroid hormones, tamoxifen, and prolactin. Journal of the National Cancer Institute 73, 313–321.CrossRefGoogle ScholarPubMed
Slamon, D. J., DeKernion, J. B., Verma, I. M. & Cline, M. J. 1984. Expression of cellular oncogenes in human malignancies. Science 224, 256–262.CrossRefGoogle ScholarPubMed
Smith, H. S., Scher, C. D. & Todaro, G. J. 1971. Induction of cell division in medium lacking serum growth factor by SV40. Virology 44, 359–370.CrossRefGoogle ScholarPubMed
Smith, J. A., Winslow, D. P. & Rudland, P. S. 1984. Different growth factors stimulate cell division of rat mammary epithelial myoepithelial and stromal cell lines in culture. Journal of Cellular Physiology 119, 320–326.CrossRefGoogle ScholarPubMed
Soto, A. & Sonnenschein, C. 1987. Cell proliferation of estrogen-sensitive cells: the case for negative control. Endocrine Reviews 8, 44–52.CrossRefGoogle ScholarPubMed
Soule, H. D. & McGrath, C. M. 1980. Estrogen responsive proliferation of clonal human breast carcinoma cells in athymic mice. Cancer Letters 10, 177–189.CrossRefGoogle ScholarPubMed
Sporn, M. B., Roberts, A. B. & Driscoll, J. S. 1985. Principles of cancer biology growth factors and differentiation. In Cancer: Principles and Practice of Oncology, 2nd ed., eds DeVita, V. T., Hellman, S. & Rosenberg, S. A., pp. 49–65. Philadelphia: H. B. Lippincott.Google Scholar
Sporn, M. B., Roberts, A. B. Wakefield, L. M. & de Crombrugghe, B. 1987. Some recent advances in the chemistry and biology of transforming growth factor beta. Journal of Cell Biology 105, 1039–1045.CrossRefGoogle ScholarPubMed
Sporn, M. B. & Roberts, A. B. 1985. Autocrine, paracrine and endocrine mechanisms of growth control. Cancer Surveys 4, 627–632.Google ScholarPubMed
Sporn, M. B. & Todaro, G. J. 1980. Autocrine secretion and malignant transformation of cells. New England Journal of Medicine 303, 878–880.CrossRefGoogle ScholarPubMed
Stiles, C. D., Capone, G. T., Scher, C. D., Antoniades, H. N., Van Wyk, J. & Pledger, W. J. 1979. Dual control of cell growth by somatomedins and platelet derived growth factor. Proceedings of the National Academy of Sciences of the U.S.A. 76, 1279–1283.CrossRefGoogle ScholarPubMed
Stromberg, K., Hudgins, W. R., Dorman, L. S., Henderson, L. E., Sowder, R. E., Shewell, B. J., Mount, C. D. & Orth, D. N. 1987. Human brain tumor-associated urinary high molecular weight transforming growth factor: a high molecular weight form of epidermal growth factor. Cancer Research 47, 1190–1196.Google ScholarPubMed
Studzinski, G. P., Brelvi, Z. S., Feldman, S. C. & Watt, R. A. 1986. Participation of c-myc protein in DNA synthesis of human cells. Science 234, 467–470.CrossRefGoogle ScholarPubMed
Sutherland, R. L., Reddel, R. R., Murphy, L. C. & Taylor, I. W. 1986. Effects of antiestrogens on cell cycle progression. In Estrogen/Antiestrogen Action and Breast Cancer Therapy, ed. Jordan, J. C., pp. 93–114. Madison: University of Wisconsin Press.Google Scholar
Swain, S. & Lippman, M. 1986. Anchorage independent epithelial colony stimulating activity in human breast cancer cell lines. Proceedings of the Annual Meeting of the American Association for Cancer Research 27, Abstract 844.Google Scholar
Takehara, K., LeRoy, E. C. & Grotendorst, G. R. 1987. TGFβ inhibition of endothelial cell proliferation alteration of EGF binding, and EGF-induced growth regulatory (competence) gene expression. Cell 49, 415–422.CrossRefGoogle ScholarPubMed
Thomas, K. A., Rios-Comdelloves, M., Gremenez-Gallego, G., DiSalvo, J., Bennett, C., Rodkey, J. & Fitzpatrick, S. 1985. Pure brain-derived acidic fibroblast growth factor is a potent angiogenic vascular endothelial cell mitogen with sequence homology to interleukin 1. Proceedings of the National Academy of Sciences of the U.S.A. 82, 6409–6423.CrossRefGoogle ScholarPubMed
Tong, B. D., Auer, D. E., Jaye, M., Kaplan, J. M., Ricca, G., McConathy, E., Drohan, W. & Deuel, T. F. 1987. cDNA clones reveal differences between human glial and endothelial platelet-derived growth factor A-chains. Nature 328, 619–621.CrossRefGoogle ScholarPubMed
Tricoli, J. V., Rail, L. B., Karakousis, C. P., Herrera, L., Petrelli, N., Bell, G. I. & Shows, T. B. 1986. Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas. Cancer Research 46, 6169–6173.Google ScholarPubMed
Tucker, R. F., Shipley, G. D., Moses, H. L. & Holley, R. W. 1984. Growth inhibitor from BSC-1 cells closely related to platelet type β transforming growth factor. Science 226, 705–707.CrossRefGoogle ScholarPubMed
Valverius, E., Bates, S., Stampfer, M., Clarke, R., McCormick, F., Salamon, D., Lippman, M. E. & Dickson, R. B. 1989. Transforming growth factor alpha production and EGF receptor expression in human mammary epithelial cells: oncogenic influence on function of EGR receptor. Molecular Endocrinology, 3 203–214.CrossRefGoogle Scholar
Van der Burg, B., Rutteman, G. R., Blankenstein, M. A., de Laat, S. W. & Van Zoelen, E. J. J. 1988. Mitogenic stimulation of human breast cancer cells in a growth factor-defined medium: synergistic action of insulin and estrogen. Journal of Cell Physiology 134, 101–108.CrossRefGoogle Scholar
Van Wyk, J. J. 1984. Somatomedins: biological actions and physiological control mechanisms. In Hormonal Proteins and Peptides, Vol. XII, ed. Li, C. H., pp. 82–125. New York: Academic Press.Google Scholar
Vonderhaar, B. K. 1988. Regulation of development of the normal mammary gland by hormones and growth factors. In Breast Cancer: Cellular and Molecular Biology, eds Lippman, M. E. & Dickson, R. B., pp. 251–266. Boston: Kluwer.CrossRefGoogle Scholar
Wahl, S. M., Hunt, D. A., Wakefield, L. M., McCartney-Francis, N., Wahl, L. M., Roberts, A. B. & Sporn, M. B. 1987. Transforming growth factor type β induces monocyte chemotaxis and growth factor production. Proceedings of the National Academy of Sciences of the U.S.A. 84, 5788–5792.CrossRefGoogle ScholarPubMed
Walker-Jones, D., Valverius, E. M., Stampfer, M. S., Clarke, R., McCormick, F., Lippman, M. E. & Dickson, R. B. 1988. Transforming growth factor beta (TGFβ) stimulates expression of milk fat globule protein in normal and oncogene transformed human mammary epithelial cells. Annual Meeting of the American Association for Cancer Research, New Orleans, LA.Google Scholar
Wang, J. L. & Hsu, Y. M. 1986. Negative regulators of cell growth. Trends in Biochemical Sciences 11, 24–26.CrossRefGoogle Scholar
Weischselbaum, R. W., Hellman, S., Piro, A., Nove, J. J. & Little, J. B. 1978. Proliferation kinetics of a human breast cancer cell line in vitro following treatment with 17β-estradiol and 1-B-o-arabinofura-nasylcytosine. Cancer Research 38, 2339–2342.Google Scholar
Welsch, C. W. 1987. Rodent models to examine in vivo hormonal regulation of mammary gland tumorigenesis. In Cellular and Molecular Biology of Mammary Cancer, eds Medina, D., Kidwell, W., Heppner, G. & Anderson, E., pp. 153–179. New York: Plenum Press.Google Scholar
Whitehead, R. H., Quirk, S. J., Vitali, A. A. et al. , 1984. A new human breast carcinoma cell line (PMC42) with stem cell characteristics. III. Hormone receptor status and responsiveness. Journal of the National Cancer Institute 73, 643–648.Google ScholarPubMed
Wilding, G., Chen, M., Gelmann, E. P. & Miller, W. R. 1987. LHRH agonists and human breast cancer cells. Nature 329, 770.CrossRefGoogle ScholarPubMed
Wrann, M., Bodmer, S., de Martin, R., Siepl, C., Hofer-Warbinek, R., Frei, K., Hofer, E. & Fontana, A. 1987. T cell suppressor factor from human glioblastoma cells is a 12.5 Kd protein closely related to transforming growth factor β. The EMBO Journal 6, 1633–1636.CrossRefGoogle ScholarPubMed
Yarden, Y., Escobedo, J. A., Kwang, W. J., Yang-Feng, T. L., Daniel, Tremble, P. M., Chen, E. Y., Ando, M. E., Harkins, R. N., Franks, U., Fried, V. A., Ullrich, A. & Williams, L. T. 1986. Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factors. Nature 323, 226–232.CrossRefGoogle Scholar
Yee, D., Favori, R. E., Huff, K. K., Paik, S., Dickson, R. B., Lebovic, G. S., Schwartz, A., Lippman, M. E. & Rosen, N. 1988. Insulin like growth factor I(IGF-I) expression and a movel IGF-I-related activity in human malignancy. Annual meetings of the American Association for Cancer Research, New Orleans, LA.Google Scholar
Yeh, H. J., Poerce, G. F. & Denel, T. F. 1987. Ultrastructure localization of a platelet-derived growth factor/v-sis-related protein(s) in cytoplasm and nucleus of simian sarcoma virus-transformed cells. Proceedings of the National Academy of Sciences of the U.S.A. 84, 23127–2321.CrossRefGoogle ScholarPubMed
Zhan, X. & Goldfarb, M. 1986. Growth factor requirements of oncogene-transformed NIH 3T3 and Balb/c 3T3 cells cultured in defined media. Molecular and Cellular Biology 6, 3541–3544.Google ScholarPubMed