The TYPHOON program is producing an atlas of spectroscopic data cubes of 44 large-angular-sized galaxies with complete spatial coverage from 3650–9000 Å. This survey provides an unparalleled opportunity to study variations in the interstellar medium (ISM) properties within individual H ii regions across the entire star-forming disks of nearby galaxies. This can provide key insights into the spatial distribution and resolved properties of the ISM to understand how efficiently metals are mixed and redistributed across spirals and dwarf galaxies. In this Proceeding, we present early science results from six nearby spiral galaxies as part of the TYPHOON program from Grasha et al. (2022). We use HIIPhot to identify the H ii regions within the galaxy based on the surface brightness of the Hα emisison line and measure variations of the H ii region oxygen abundance. In this initial work, we find that while the spiral pattern plays a role in organizing the ISM, it alone does not establish the relatively uniform azimuthal variations we observe across all the galaxies. Differences in the metal abundances are more likely driven by the strong correlations with the local physical conditions. We find a strong and positive correlation between the ionization parameter and the local abundances as measured by the relative metallicity offset Δ(O/H), indicating a tight relationship between local physical conditions and their localized enrichment of the ISM. These variations can be explained by a combination of localized, star formation-driven self-enrichment and large-scale mixing-driven dilution due to the passing of spiral density waves.