Radio-loud AGNs can inhabit regions with a very rich ISM. The presence of this rich medium is likely related to the origin and evolution of the host galaxy and of the active nucleus. Recent observations show that a large fraction of radio galaxies contains a significant young stellar population. This supports the idea that mergers are responsible for both the starburst phase and the triggering of the nuclear activity. The gas that reaches the central regions can have quite disturbed kinematics, likely due to the effects of the AGN activity and in particular of the powerful radio jets. The recent detection of fast nuclear gas outflows, observed both in ionised and neutral gas, is giving new and important insights into the physical conditions of the gaseous medium around the nucleus and the interaction between the AGN and this medium. Finally, as another example of the interplay between the radio activity and the ISM, the possibility of star formation induced by the passage of the radio jet will be discussed.To search for other articles by the author(s) go to: http://adsabs.harvard.edu/abstract_service.html