Hostname: page-component-7479d7b7d-k7p5g Total loading time: 0 Render date: 2024-07-11T07:59:36.888Z Has data issue: false hasContentIssue false
  • English
  • Français

SIMULATING BIORESORBABLE LATTICE STRUCTURES TO ENABLE TIME-DEPENDENT STIFFNESS IN FRACTURE FIXATION DEVICES

Published online by Cambridge University Press:  19 June 2023

Barnaby Hawthorn ,
Andrew Triantaphyllou ,
Farhan Khan ,
Rosemary Dyson  and
Lauren E. J. Thomas-Seale
Barnaby Hawthorn*
Affiliation:
School of Engineering, University of Birmingham;
Andrew Triantaphyllou
Affiliation:
The Manufacturing Technology Centre (MTC) Ltd, United Kingdom;
Farhan Khan
Affiliation:
The Manufacturing Technology Centre (MTC) Ltd, United Kingdom;
Rosemary Dyson
Affiliation:
School of Mathematics, University of Birmingham, United Kingdom
Lauren E. J. Thomas-Seale
Affiliation:
School of Engineering, University of Birmingham;
*
Hawthorn, Barnaby, University of Birmingham, United Kingdom, BXH481@student.bham.ac.uk

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Additive manufacture (AM) enables a greatly increased design freedom owing to its ability to manufacture otherwise difficult or impossible geometries. However, design creativity can often present itself as a barrier to realising the advantages that AM could offer. In this study the use of AM, bioresorbable materials and lattice design is considered as a method of satisfying contradicting design requirements during fracture healing. Often, immediately after a fracture high stiffness fixation is required; contradictingly during the remodelling phase high stiffness can inhibit bone healing. This study proposes the use of a bioresorbable body centred cubic (BCC) or face centred cubic (FCC) lattice structure to meet the need for tailored variation in implant stiffness over time. To reduce computational expense of lattice modelling a method is outlined, including the use of homogenisation. Results show homogenised representations perform within 5.2% and 1.4% for BCC and FCC unit cells respectively, with a 95% reduction in computational expense. Using resorption rates from the literature, time-dependent change in unit cell geometry was also modelled, showing the way in which a decrease in stiffness over time could be achieved.

Keywords

Additive ManufacturingBiomedical designSimulation4D PrintingLattices
Type
Article
Information
Proceedings of the Design Society , Volume 3: ICED23 , July 2023 , pp. 3175 - 3184
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
Copyright
The Author(s), 2023. Published by Cambridge University Press

References

Alghamdi, A. et al. (2020) ‘Effect of additive manufactured lattice defects on mechanical properties: an automated method for the enhancement of lattice geometry’, The International Journal of Advanced Manufacturing Technology, 108(3), pp. 957–971. Available at: https://doi.org/10.1007/s00170-020-05394-8.CrossRefGoogle Scholar
Alwattar, T.A. and Mian, A. (2019) ‘Development of an elastic material model for bcc lattice cell structures using finite element analysis and neural networks approaches’, Journal of Composites Science, 3(2), p. 33. Available at: https://doi.org/10.3390/jcs3020033.CrossRefGoogle Scholar
Arabnejad, S. and Pasini, D. (2013) ‘Mechanical properties of lattice materials via asymptotic homogenization and comparison with alternative homogenization methods’, International Journal of Mechanical Sciences, 77, pp. 249–262. Available at: https://doi.org/10.1016/j.ijmecsci.2013.10.003.CrossRefGoogle Scholar
Arif, U. et al. (2019) ‘Biocompatible Polymers and their Potential Biomedical Applications: A Review’, Current Pharmaceutical Design, 25(34), pp. 3608–3619. Available at: https://doi.org/10.2174/1381612825999191011105148.CrossRefGoogle ScholarPubMed
Augat, P., Hollensteiner, M. and von Rüden, C. (2021) ‘The role of mechanical stimulation in the enhancement of bone healing’, Injury, 52, pp. S78–S83. Available at: https://doi.org/10.1016/j.injury.2020.10.009.CrossRefGoogle ScholarPubMed
Augat, P. and von Rüden, C. (2018) ‘Evolution of fracture treatment with bone plates’, Injury, 49, pp. S2–S7. Available at: https://doi.org/10.1016/S0020-1383(18)30294-8.CrossRefGoogle ScholarPubMed
Benedetti, M. et al. (2021) ‘Architected cellular materials: A review on their mechanical properties towards fatigue-tolerant design and fabrication’, Materials Science and Engineering: R: Reports, 144, p. 100606. Available at: https://doi.org/10.1016/j.mser.2021.100606.CrossRefGoogle Scholar
Hak, D.J. et al. (2010) ‘The Influence of Fracture Fixation Biomechanics on Fracture Healing’, Orthopedics, 33(10).CrossRefGoogle ScholarPubMed
Hermawan, H. (2012) ‘Biodegradable Metals: State of the Art’, in. Springer, Berlin, Heidelberg, pp. 13–22. Available at: https://doi.org/10.1007/978-3-642-31170-3_2.CrossRefGoogle Scholar
Jagodzinski, M. and Christian, K. (2007) ‘Effect of mechanical stability on fracture healing — an update’, Injury, 38(1), pp. S3–S10.CrossRefGoogle ScholarPubMed
Kanagalingam, S. et al. (2019) ‘Design Principles to Increase the Patient Specificity of High Tibial Osteotomy Fixation Devices’. Available at: https://doi.org/10.1017/dsi.2019.96.CrossRefGoogle Scholar
Kannan, M.B. et al. (2017) ‘Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications’, Scientific Reports, 7(1). Available at: https://doi.org/10.1038/s41598-017-15873-w.CrossRefGoogle ScholarPubMed
Koeppe, A. et al. (2018) ‘Efficient numerical modeling of 3D-printed lattice-cell structures using neural networks’, Manufacturing Letters, 15, pp. 147–150. Available at: https://doi.org/10.1016/j.mfglet.2018.01.002.CrossRefGoogle Scholar
Lohmuller, P. et al. (2018) ‘Stress Concentration and Mechanical Strength of Cubic Lattice Architectures’, Materials, 11(7), p. 1146. Available at: https://doi.org/10.3390/ma11071146.CrossRefGoogle ScholarPubMed
Maskery, I. et al. (2015) ‘Mechanical Properties of Ti-6Al-4V Selectively Laser Melted Parts with Body-Centred-Cubic Lattices of Varying cell size’, Experimental Mechanics, 55(7), pp. 1261–1272. Available at: https://doi.org/10.1007/s11340-015-0021-5.CrossRefGoogle Scholar
Mostaed, E. et al. (2018) ‘Zinc-based alloys for degradable vascular stent applications’, Acta Biomaterialia. Acta Materialia Inc. Available at: https://doi.org/10.1016/j.actbio.2018.03.005.CrossRefGoogle Scholar
Omairey, S.L., Dunning, P.D. and Sriramula, S. (2019) ‘Development of an ABAQUS plugin tool for periodic RVE homogenisation’, Engineering with Computers, 35(2), pp. 567–577. Available at: https://doi.org/10.1007/s00366-018-0616-4.CrossRefGoogle Scholar
Prakasam, M. et al. (2017) ‘Biodegradable materials and metallic implants-A review’, Journal of Functional Biomaterials. MDPI AG. Available at: https://doi.org/10.3390/jfb8040044.CrossRefGoogle ScholarPubMed
Qin, Y., Wen, P., Guo, H., et al. (2019) ‘Additive manufacturing of biodegradable metals: Current research status and future perspectives’, Acta Biomaterialia. Acta Materialia Inc. Available at: https://doi.org/10.1016/j.actbio.2019.04.046.Google Scholar
Qin, Y., Wen, P., Voshage, M., et al. (2019) ‘Additive manufacturing of biodegradable Zn-xWE43 porous scaffolds: Formation quality, microstructure and mechanical properties’, Materials and Design, 181, p. 107937. Available at: https://doi.org/10.1016/j.matdes.2019.107937.CrossRefGoogle Scholar
RAENG (2013) ‘Additive manufacturing: opportunities and constraints’. Royal Academy of Engineering. Available at: https://raeng.org.uk/media/ak3htcyo/additive_manufacturing.pdf (Accessed: 18 November 2022).Google Scholar
da Silva, D. et al. (2018) ‘Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems’, Chemical Engineering Journal, 340, pp. 9–14. Available at: https://doi.org/10.1016/j.cej.2018.01.010.CrossRefGoogle ScholarPubMed
Song, C., Ooi, E.T. and Natarajan, S. (2018) ‘A review of the scaled boundary finite element method for two-dimensional linear elastic fracture mechanics’, Engineering Fracture Mechanics, 187, pp. 45–73. Available at: https://doi.org/10.1016/j.engfracmech.2017.10.016.CrossRefGoogle Scholar
Thanigaiarasu, P. (2020) ‘Biomimetics in the design of medical devices’, in Trends in Development of Medical Devices. Elsevier Inc., pp. 35–41. Available at: https://doi.org/10.1016/B978-0-12-820960-8.00003-4.CrossRefGoogle Scholar
Tollenaere, H. and Caillerie, D. (1998) ‘Continuous modeling of lattice structures by homogenization’, Advances in Engineering Software, 29(7–9), pp. 699–705. Available at: https://doi.org/10.1016/S0965-9978(98)00034-9.CrossRefGoogle Scholar
Venezuela, J. and Dargusch, M.S. (2019) ‘The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review’, Acta Biomaterialia. Acta Materialia Inc. Available at: https://doi.org/10.1016/j.actbio.2019.01.035.CrossRefGoogle Scholar
Vlădulescu, F. and Constantinescu, D.M. (2020) ‘Lattice structure optimization and homogenization through finite element analyses’, Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications, 234(12), pp. 1490–1502. Available at: https://doi.org/10.1177/1464420720945744.CrossRefGoogle Scholar
Wang, X. et al. (2019) ‘In vivo study of the efficacy, biosafety, and degradation of a zinc alloy osteosynthesis system’, Acta Biomaterialia, 92, pp. 351–361. Available at: https://doi.org/10.1016/j.actbio.2019.05.001.CrossRefGoogle ScholarPubMed
Wen, P. et al. (2018) ‘Laser additive manufacturing of Zn metal parts for biodegradable applications: Processing, formation quality and mechanical properties’, Materials and Design, 155, pp. 36–45. Available at: https://doi.org/10.1016/j.matdes.2018.05.057.CrossRefGoogle Scholar
Witte, F. (2010) ‘The history of biodegradable magnesium implants: A review’, Acta Biomaterialia. Elsevier. Available at: https://doi.org/10.1016/j.actbio.2010.02.028.Google Scholar
Zhang, Z., Demir, K.G. and Gu, G.X. (2019) ‘Developments in 4D-printing: a review on current smart materials, technologies, and applications’, International Journal of Smart and Nano Materials, 10(3), pp. 205–224. Available at: https://doi.org/10.1080/19475411.2019.1591541.CrossRefGoogle Scholar